DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fili and Chadl

DIOPT Version :9

Sequence 1:	NP_001369108.1	Gene:	Fili / 5740472	FlyBaseID:	FBgn0085397	Length:	789	Species:	Drosophila melanogaster
Sequence 2:	XP_006520805.1	Gene:	Chadl / 214685	MGIID:	3036284	Length:	759	Species:	Mus musculus

Alignment Length:	817	Identity:	191/817 - (23%)
Similarity:	275/817 - (33%)	Gaps:	243/817 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 AIPVLLLLLLTLVILPPE---TTAFCPSKCQCLGGEANSR--ALCVDAALEDVPIQLNPETKYIN 79
            :|.|.:|||..:::..|.   ....||..|.|    .|||  ..|....|.:||..: ||
Mouse    18 SIWVFMLLLFMVLLQSPAWHVAAQRCPQTCVC----DNSRRHVTCRHQNLTEVPNTI-PE----- 72

  Fly    80 LTVNRIRTLEFSLPFYMKLEILDLSQNIIETLGSKNFEYQSELRTLNLSRNLVSSLHKHAFKGLT 144
            ||                 :.|||..||::.|.:..|:....|..|:|....|..:.:.||:||.
Mouse    73 LT-----------------QRLDLQGNILKVLPAAAFQDLPHLTHLDLRNCQVEMVAEGAFRGLG 120

  Fly   145 NLLLLDLSFNRIETVHPTALSDLASLVELDLTNNNIVSLEDNCFKGMNTLEVLVFRNNRLLDVPA 209
            .||||:|:.||:.|:...||..|.||..|:|..|.:..|....|..:.:|..|...:|.|:.:||
Mouse   121 RLLLLNLASNRLSTLPQEALDGLGSLRRLELEGNMLEELRPGTFGALGSLTTLNLAHNALVYLPA 185

  Fly   210 SNLWHLHALKSLDMSLNLVEFVRNDSFEGLKELLALSVQGNVMSELDLSAFEGLISLKHLDLSDN 274
            .                        :|:||.....|.:..|.:|.|...|..||.:|:.|.|..|
Mouse   186 M------------------------AFQGLLRTRWLQLSHNALSVLAPEALAGLPALRRLSLHHN 226

  Fly   275 NLTMVPTQQLSKLSNLTYLNLGGNRFSQLPAVAFLNLFHLRELHLSRLDFLQRIDSRAFVDNTHL 339
            .|..:|...||:..:|..|.||.|..:.......|.|..||||.|.. ..||.:..|||.....|
Mouse   227 ELQALPGAALSQARSLARLELGHNPLTYTGEEDGLALPGLRELALDH-GSLQALGPRAFAHCPRL 290

  Fly   340 QTLHLNNNPQLSDIPMRLFQGNPNILEVYMQSNSLQTLYSAQFPVDQLQKLYLGDNPLQCNCS-- 402
            .||.|                         :.|.|.||...|.| .||::|.|..|||.|.|.
Mouse   291 HTLDL-------------------------RGNQLTTLPPLQVP-GQLRRLRLQGNPLWCACHAR 329

  Fly   403 --LLWLWRLVTGNFEGVDPGMEHAAGGAVAALAKEADDEELADEATAVASTDDG-------VAAL 458
              |.||.|....: :|...|.....|.|:..|.    ..:|.....|.|...||       ....
Mouse   330 PLLEWLVRARVRS-DGACRGPRRLRGEALDTLR----PSDLRCPGDAAAGDGDGDEDEDRPAGPR 389

  Fly   459 AAYIAEQHIVNALHTTEPSAYELATSSSNRNSGILRMDRQQIGCDIWRDKVRTRRKLLTMSEGEI 523
            |..:...|...|..|..|.|  .|..:..|:|.......|.:......|     .:||.:.....
Mouse   390 APPLRSPHGEAAWATPCPPA--CACVAETRHSTCDGRGLQAVPRGFPND-----TQLLDLRRNHF 447

  Fly   524 -TCP-------AHIVTV---VCAVITCLLVAMIGISVLYYL-----------------------R 554
             :.|       .|:|::   .|.|......|:.|:..|.||                       .
Mouse   448 PSVPRAAFPGLRHLVSLHLQHCGVAELEPGALAGLDRLLYLYLSHNQLSGLSAAALEGAPNLGYL 512

  Fly   555 FVKRRRKLLHERGPMRTSKSIINVH------DRILQGHNPGGLGLGMSMTLGGGNHVNGLGMTLN 613
            :::..|.|......:|...:::::|      ||:..|...|...|.....  .|||:.
Mouse   513 YLEHNRFLRIPGTALRALPTLVSLHLQDNAVDRLAPGDLAGARALRCLYL--SGNHIT------- 568

  Fly   614 YPHHAQTLQAHHHYHQAMPLQSHGGNGNHEYQQTTLPQLDKLELERYLAAQTIANEYRALKPWEL 678
                           |..|    |..|       ...:|:||.|:|        |..|     |:
Mouse   569 ---------------QVSP----GALG-------PARELEKLHLDR--------NRLR-----EV 594

  Fly   679 PVKEADDEPEHLYERFDHYEYPDTHTMSKLKQAASLNHSNSSAGP-SPVPPSSGKPHVVYVXRGR 742
            |....:..|                         :|.....|..| ..:|..:.:|
Mouse   595 PTGALEGLP-------------------------ALKELQLSGNPLRALPDGAFQP--------- 625

  Fly   743 GTGERVSQI---NTDIEMV----------GLNHLHLH 766
             .|..:.|:   ::|:|.:          ||..|:||
Mouse   626 -VGRSLQQLFLNSSDLEQISPRAFSGLGKGLRSLYLH 661

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fili	NP_001369108.1	leucine-rich repeat	75..97	CDD:275378	2/21 (10%)
		leucine-rich repeat	98..121	CDD:275380	7/22 (32%)
		LRR_8	120..180	CDD:404697	24/59 (41%)
		leucine-rich repeat	122..145	CDD:275380	8/22 (36%)
		leucine-rich repeat	146..169	CDD:275380	11/22 (50%)
		LRR	<161..>354	CDD:227223	55/192 (29%)
		leucine-rich repeat	170..193	CDD:275380	6/22 (27%)
		leucine-rich repeat	194..217	CDD:275380	6/22 (27%)
		leucine-rich repeat	218..265	CDD:275380	10/46 (22%)
		leucine-rich repeat	266..289	CDD:275380	8/22 (36%)
		leucine-rich repeat	290..313	CDD:275380	7/22 (32%)
		leucine-rich repeat	314..338	CDD:275380	10/23 (43%)
		LRR_8	337..397	CDD:404697	15/59 (25%)
		leucine-rich repeat	339..360	CDD:275380	4/20 (20%)
Chadl	XP_006520805.1	PRK15370	<32..>322	CDD:185268	105/367 (29%)
		leucine-rich repeat	54..72	CDD:275380	4/18 (22%)
		leucine-rich repeat	74..97	CDD:275380	8/39 (21%)
		leucine-rich repeat	98..121	CDD:275380	8/22 (36%)
		leucine-rich repeat	122..145	CDD:275380	11/22 (50%)
		leucine-rich repeat	146..169	CDD:275380	6/22 (27%)
		LRR_8	169..228	CDD:338972	20/82 (24%)
		leucine-rich repeat	170..193	CDD:275380	9/46 (20%)
		leucine-rich repeat	194..217	CDD:275380	7/22 (32%)
		leucine-rich repeat	218..241	CDD:275380	8/22 (36%)
		leucine-rich repeat	242..265	CDD:275380	7/22 (32%)
		leucine-rich repeat	266..289	CDD:275380	10/23 (43%)
		leucine-rich repeat	312..351	CDD:275380	14/39 (36%)
		LRRNT	405..439	CDD:214470	7/40 (18%)
		leucine-rich repeat	437..460	CDD:275380	3/22 (14%)
		LRR_8	460..519	CDD:338972	9/58 (16%)
		leucine-rich repeat	461..484	CDD:275380	5/22 (23%)
		leucine-rich repeat	485..508	CDD:275380	3/22 (14%)
		LRR	<507..>687	CDD:227223	40/238 (17%)
		leucine-rich repeat	509..532	CDD:275380	3/22 (14%)
		leucine-rich repeat	533..556	CDD:275380	5/22 (23%)
		leucine-rich repeat	557..580	CDD:275380	8/57 (14%)
		leucine-rich repeat	581..604	CDD:275380	10/60 (17%)
		leucine-rich repeat	605..629	CDD:275380	6/33 (18%)
		leucine-rich repeat	630..653	CDD:275380	3/22 (14%)
		leucine-rich repeat	655..677	CDD:275380	4/7 (57%)
		LRRCT	685..733	CDD:214507
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24373
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.010