DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fili and Elfn2

DIOPT Version :9

Sequence 1:	NP_001369108.1	Gene:	Fili / 5740472	FlyBaseID:	FBgn0085397	Length:	789	Species:	Drosophila melanogaster
Sequence 2:	NP_001345621.1	Gene:	Elfn2 / 207393	MGIID:	3608416	Length:	823	Species:	Mus musculus

Alignment Length:	818	Identity:	158/818 - (19%)
Similarity:	267/818 - (32%)	Gaps:	277/818 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    95 YMKLEILDLSQNIIETLGSKNFEYQSELRTLNLSRNLVSSLHKHAFKGLTNLLLLDLSFNRIETV 159
            |:.|.|...:|...||                :.:::.|::|.           |.|:.|:::.|
Mouse    33 YVWLAICSQNQPPYET----------------IPQHINSTVHD-----------LRLNENKLKAV 70

  Fly   160 HPTALSDLASLVELDLTNNNIVSLEDNCFKGMNTLEVLVFRNNRLLDVPASNLWHLHALKSLDMS 224
            ..::|:...:|.:|:||.|.|..:||..|.|..:|:||....|||     |||
Mouse    71 LYSSLNRFGNLTDLNLTKNEISYIEDGAFLGQTSLQVLQLGYNRL-----SNL------------ 118

  Fly   225 LNLVEFVRNDSFEGLKELLALSVQGNVMSELDLSAFEGLISLKHLDLSDNNLTMVPTQQLSKLSN 289
                   ......|:..|..|.||.|::..:..:||....||..:|||.|.|:.:.....:.|::
Mouse   119 -------TEGMLRGMSRLQFLFVQHNLIEVVTPTAFSECPSLISIDLSSNRLSRLDGATFASLAS 176

  Fly   290 LTYLNLGGNRFS----QLPAVAFLNLFHLRELHLSRLDFLQRIDSRAFVDNTHLQTLHLNNNPQL 350
            |....|.||.|:    ....:|:|.:|:....:..||.
Mouse   177 LMVCELAGNPFNCECDLFGFLAWLVVFNNVTKNYDRLQ--------------------------- 214

  Fly   351 SDIPMRLFQGNPNIL-EVYMQSNSLQTLYSAQFPVDQLQKLYLGDNPLQCNCSLLWLWRLVTGNF 414
            .:.| |.|.|.|.:: ..|...|::..                    ||..|.
Mouse   215 CESP-REFAGYPLLVPRPYHSLNAITV--------------------LQAKCR------------ 246

  Fly   415 EGVDPG--MEHAAGGAVAALAKEAD-------DEELADEATAVASTDDGVAALAAYIAEQHIVNA 470
            .|..|.  :.|....:..| .:|.|       ||.|:.|..|.::||    |.|....:.|.|..
Mouse   247 NGSMPARPVSHPTPYSTDA-QREPDENSGFNPDEILSVEPPASSTTD----ASAGPAIKLHQVTF 306

  Fly   471 LHTT------EP--SAYELATSSSNRNSGILRM-DRQQIGCDIWRDKVR--------------TR 512
            ...|      .|  ..|.|...:::..|.::.: ::::|   :..||:|              :|
Mouse   307 TSATLVVIIPHPYSKMYVLVQYNNSYFSDVMTLKNKKEI---VTLDKLRAHTEYTFCVTSLRNSR 368

  Fly   513 R---KLLTMSEGEIT----CPAHIVTV--VCAVITCLLVAMIGISVLYYLRFVKRRRKLLHERGP 568
            |   ..||.:..::.    .|:...|.  :..::.||...:|.:..:||.  :::||....::..
Mouse   369 RFNHTCLTFTTRDLVPGDLAPSTSTTTHYIMTILGCLFGMVIVLGAVYYC--LRKRRMQEEKQKS 431

  Fly   569 MRTSKSIIN------------VHDRILQGHNP---------------------GGL--GLGMSMT 598
            :...|:|:.            ||.....|..|                     .||  ||.....
Mouse   432 VNVKKTILEMRYGADVDAGSIVHAAQKLGEPPVLPVARMSSIPSMVGEKLPASKGLEAGLDTPKV 496

  Fly   599 LGGGNHV----------------------NGLGMTLNYPHHAQTL----QAHHHYHQAMPLQS-- 635
            ...||::                      ||.|........|:.:    |..::...|:.|.|
Mouse   497 ATKGNYIEVRTGAAGDSLARPEEELPEIENGQGSAAEISTIAKEVDKVNQIINNCIDALKLDSAS 561

  Fly   636 -------HGGNGNHE--YQQTTLPQLDKLELERYLAAQTIANEYRALKPWEL--PVKEADDEPEH 689
                   .||.|:.:  ::..:||...        ||.:.|......:|..|  |.||:...|..
Mouse   562 FLGGGGGGGGGGDSDLAFECQSLPAAP--------AASSAATPGALERPSFLSPPYKESSHHPLQ 618

  Fly   690 LYERFDHYEYPDTHTMSKLKQAASLNHSNSSAGPSPVPPSSGKPHVVYVXRGRGTGERVSQINTD 754
            .....|......|.::|......|....:......|.|....|....|:.:|       |.:|:.
Mouse   619 RQLSADAAVSRKTCSVSSSGSIKSAKVFSLDVPDHPTPTGLAKSDSKYIEKG-------SPLNSP 676

  Fly   755 IEMV---------------GLNHL------HLHHHHHN 771
            ::.:               |::||      |...|.|:
Mouse   677 LDRLPLVPTGSSGSSGGGGGIHHLEVKPAYHCSEHRHS 714

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fili	NP_001369108.1	leucine-rich repeat	75..97	CDD:275378	1/1 (100%)
		leucine-rich repeat	98..121	CDD:275380	5/22 (23%)
		LRR_8	120..180	CDD:404697	12/59 (20%)
		leucine-rich repeat	122..145	CDD:275380	2/22 (9%)
		leucine-rich repeat	146..169	CDD:275380	5/22 (23%)
		LRR	<161..>354	CDD:227223	46/196 (23%)
		leucine-rich repeat	170..193	CDD:275380	10/22 (45%)
		leucine-rich repeat	194..217	CDD:275380	9/22 (41%)
		leucine-rich repeat	218..265	CDD:275380	8/46 (17%)
		leucine-rich repeat	266..289	CDD:275380	7/22 (32%)
		leucine-rich repeat	290..313	CDD:275380	7/26 (27%)
		leucine-rich repeat	314..338	CDD:275380	2/23 (9%)
		LRR_8	337..397	CDD:404697	7/60 (12%)
		leucine-rich repeat	339..360	CDD:275380	3/20 (15%)
Elfn2	NP_001345621.1	LRR 1	56..77		6/31 (19%)
		leucine-rich repeat	60..80	CDD:275378	5/19 (26%)
		LRR_8	80..139	CDD:404697	25/82 (30%)
		LRR 2	80..101		9/20 (45%)
		leucine-rich repeat	81..104	CDD:275378	10/22 (45%)
		LRR 3	104..125		9/44 (20%)
		leucine-rich repeat	105..128	CDD:275378	10/46 (22%)
		LRR_8	127..187	CDD:404697	19/59 (32%)
		LRR 4	128..149		7/20 (35%)
		leucine-rich repeat	129..152	CDD:275378	7/22 (32%)
		LRR 5	152..173		7/20 (35%)
		leucine-rich repeat	153..166	CDD:275378	6/12 (50%)
		PCC	157..>227	CDD:188093	21/97 (22%)
		leucine-rich repeat	177..189	CDD:275378	5/11 (45%)
		leucine-rich repeat	200..226	CDD:275380	8/53 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	249..294		12/49 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	590..624		8/33 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24373
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100