Protein Alignment Fili and lron-1

DIOPT Version :9

• Sequence 1: NP_001369108.1
• Gene: Fili / 5740472
• FlyBaseID: FBgn0085397
• Length: 789
• Species: Drosophila melanogaster
• Sequence 2: NP_510424.4
• Gene: lron-1 / 181553
• WormBaseID: WBGene00008093
• Length: 607
• Species: Caenorhabditis elegans
• Alignment Length: 680
• Identity: 144/680 - (21%)
• Similarity: 259/680 - (38%)
• Gaps: 166/680 - (24%)

  Fly    16 WLCGAIPVLLLLLLTLVILPPET---TAFCPSKCQCLGGEANSRALCVDAALE------------ 65
            |:....|       ||.:..|.|   |.:......|.||.:      :||.||
 Worm    13 WVYSQCP-------TLQLQEPCTCTSTRYEAVSINCDGGSS------LDAVLESLSNSPQAIDSL 64

  Fly    66 ---DVPIQLNP-------ETKYINLTVNRIRTLE---FSLPFYMKLEILDLSQNIIETLGSKNFE 117
               :.||:..|       :.|.:.|..|.:|:..   |:......||.|::..|.|:.:......
 Worm    65 TISNTPIEKMPGYAFQGFQIKKLFLRNNGLRSFHPNTFTGNLENSLEELEIRGNYIDGIPQSGVS 129

  Fly   118 YQSELRTLNLSRNLVSSLHKHAF---KGLTNLLLLDLSFNRIETVHPTALSDLASLVELDLTNNN 179
            ...:|:.|:|..||:..:..:||   ....:||.||||.|.:..:|||.|..|.:|.:|.|..|.
 Worm   130 ILKQLKILSLPDNLIEYVQDNAFLSYHSRDSLLKLDLSANNLTAIHPTGLLGLENLSQLSLDKNL 194

  Fly   180 IVSLEDNCFKGMNTLEVLVFRNNRLLDVPASNLWHLHALKSLDMSLNLVEFVRNDSFEGLKELLA 244
            :..:.....:.:.:||.|....||:..:..::| .|..||||.:.:|.:..:.:|||.....|..
 Worm   195 LSEIPSQALENIPSLEDLSLGVNRIHTISRNSL-PLPNLKSLSLEVNQIRLIPSDSFSETPLLSY 258

  Fly   245 LSVQGNVMSELDLS----------------------------------------AFEGLISLKHL 269
            |.:..|:::.:|.|                                        ||:...||..|
 Worm   259 LYLGNNLLTSIDASMFLHIGGLKVLSMSNNKDITSIQANGKLSVQQFKLCICILAFQHAPSLIRL 323

  Fly   270 DLSDNNLTMVPTQQLSKLSNLTYLNLGGNRFSQLPAVAFLNLFHLRELHLSRLDFLQRIDSRAFV 334
            :|.|.:::.:..:.|.|:.::..:.|..|:.:::....|.||..|.||.||. :.:..:|..||.
 Worm   324 ELFDCSISRIEPKSLQKVQHIQVILLSRNQITRISHDTFSNLPELSELDLSG-NSINAVDDFAFS 387

  Fly   335 DNTHLQTLHLNNNPQLSDIPMRLFQGNPNILEVYMQSNSLQTLYSAQFPVDQLQKLYLGDNPLQC 399
            ....|.:|.|::| :|..:|..:      |.:..||..:        .||.  :||.:.:||.:|
 Worm   388 QLPMLTSLDLSSN-RLESLPSNV------IYDSLMQKKT--------SPVQ--RKLSIQNNPWRC 435

  Fly   400 NCSLLWLWRLVTGNFEGVDPGMEHAAGGAVAALAKEADDEELADEATAVASTDDGVAALAAYIAE 464
            :..|:||.:.:..|             |.|...|        ::...|...|...::.|.....:
 Worm   436 DKDLMWLRKWLRDN-------------GDVTTAA--------SNSPPAKCWTPSNLSGLDLRQTD 479

  Fly   465 QHIVNALHTTEP--SAYELATSSSNRNSGILRMDRQQIGCDIWRDKVRTRRKLLTMSEGEITCPA 527
            ..:.:  .||:|  ..::........::|..::..|....::
 Worm   480 SKLPH--KTTKPPVDQFQYKNQQVTNSNGTSQLGYQNPHTEV----------------------- 519

  Fly   528 HIVTVVCAVITCLLVAMIGISVL-YYLRFV----KRRRKLLHERGPMRTSKSIINVHDRILQGHN 587
            :.:.:|..::..:||..:...:| |.:||:    :.:.|.......:.:|..|.|::
 Worm   520 NGLALVGLILGIVLVVFVSCIILGYLMRFIFLSYEAKTKPNVFGSTISSSGCIRNMY-------- 576

  Fly   588 PGGLGLGMSMTLGGGNHVNGLGMTLNYPHH 617
             ||.|..:|...|..:..|. .:.||.|.|
 Worm   577 -GGDGTLVSEDHGHPSSANN-NVYLNRPRH 604

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Fili	NP_001369108.1	leucine-rich repeat	75..97	CDD:275378	5/24 (21%)
		leucine-rich repeat	98..121	CDD:275380	5/22 (23%)
		LRR_8	120..180	CDD:404697	23/62 (37%)
		leucine-rich repeat	122..145	CDD:275380	7/25 (28%)
		leucine-rich repeat	146..169	CDD:275380	12/22 (55%)
		LRR	<161..>354	CDD:227223	55/232 (24%)
		leucine-rich repeat	170..193	CDD:275380	4/22 (18%)
		leucine-rich repeat	194..217	CDD:275380	7/22 (32%)
		leucine-rich repeat	218..265	CDD:275380	15/86 (17%)
		leucine-rich repeat	266..289	CDD:275380	6/22 (27%)
		leucine-rich repeat	290..313	CDD:275380	5/22 (23%)
		leucine-rich repeat	314..338	CDD:275380	8/23 (35%)
		LRR_8	337..397	CDD:404697	14/59 (24%)
		leucine-rich repeat	339..360	CDD:275380	6/20 (30%)
lron-1	NP_510424.4	PRK15370	<58..>289	CDD:185268	56/231 (24%)
		leucine-rich repeat	85..109	CDD:275380	5/23 (22%)
		leucine-rich repeat	110..133	CDD:275380	5/22 (23%)
		leucine-rich repeat	134..157	CDD:275380	7/22 (32%)
		leucine-rich repeat	161..184	CDD:275380	12/22 (55%)
		leucine-rich repeat	185..208	CDD:275380	4/22 (18%)
		leucine-rich repeat	209..231	CDD:275380	7/22 (32%)
		leucine-rich repeat	232..255	CDD:275380	8/22 (36%)
		leucine-rich repeat	256..279	CDD:275380	5/22 (23%)
		leucine-rich repeat	280..319	CDD:275380	2/38 (5%)
		leucine-rich repeat	320..343	CDD:275380	6/22 (27%)
		LRR_8	343..402	CDD:338972	17/60 (28%)
		leucine-rich repeat	344..367	CDD:275380	5/22 (23%)
		leucine-rich repeat	368..391	CDD:275380	8/23 (35%)
		leucine-rich repeat	392..410	CDD:275380	6/24 (25%)
		leucine-rich repeat	414..435	CDD:275378	8/30 (27%)
		LRRCT	431..>472	CDD:214507	12/61 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D187891at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010