Protein Alignment Fili and lron-2

DIOPT Version :9

• Sequence 1: NP_001369108.1
• Gene: Fili / 5740472
• FlyBaseID: FBgn0085397
• Length: 789
• Species: Drosophila melanogaster
• Sequence 2: NP_505402.1
• Gene: lron-2 / 179309
• WormBaseID: WBGene00022789
• Length: 575
• Species: Caenorhabditis elegans
• Alignment Length: 673
• Identity: 142/673 - (21%)
• Similarity: 243/673 - (36%)
• Gaps: 211/673 - (31%)

  Fly    26 LLLLTLVILPPETTAF--CPS---KCQCL-------------GGEANSRALCVDAALEDVPIQLN 72
            ::|.|||:     |.:  ||:   .|:|.             .|...:....:.|| .|:||.
 Worm     6 IILATLVV-----TVYGQCPALSGACRCAPSVYEPVAIICQNAGSLQNAIQAIQAA-RDIPID-- 62

  Fly    73 PETKYINLTVNRIRTLEFSLPFYMKLEILDLSQNIIETLGSKNFEYQSELRTLNLSRNLVSSLHK 137
                                    .|.|||.:   |.|:.:..|:..:.|| |.|:||.:.::..
 Worm    63 ------------------------SLTILDTA---IPTIPANAFQSFTILR-LVLNRNTLQNIDD 99

  Fly   138 HAFKG--LTNLLLLDLSFNRIETVHPTALSDLASLVELDLTNNNIVSLED---NCFKGMNTLEVL 197
            .||.|  |.:|:.|||:.|.:..:..|.:..|.:|.:|.|..|.|..|..   |.|:..:.|..|
 Worm   100 QAFNGPLLDSLIELDLNDNNLGQIPQTGIPRLRNLRKLYLNRNRINQLSSTAFNAFESRDLLLKL 164

  Fly   198 VFRNNRLLDV---PASNLWHLHALKSLDMSLNLVEFVRNDSFEGLKELLA-LSVQGNVMSELDLS 258
            ....|||.|.   .|:....|..|:.|.:..|.:..:.:.:....:..|. |::..|.::|:.:.
 Worm   165 ELAGNRLTDATLGDATVFRPLTLLQELSLETNSLTSIPSSALVNQRNTLTNLNLGLNSINEVPVG 229

  Fly   259 AFEGLISLKHLDLSDNNLTMVPTQQLSKLSNLTYLNLGGNRF----------------------- 300
            |.:..: |..|.|..|.:|::|.|....:.||.:|.:.||:|
 Worm   230 ALDFPV-LSSLSLEFNGITVIPPQAFQGVPNLQFLYMTGNKFPSWAPEMFRYITQLKTLGIGETP 293

  Fly   301 -SQLPAVAFLNLFHLRELHLSR--LDFLQRIDSRAFVDNTHLQTLHLNNNPQLSDIPMRLFQGNP 362
             |.:|..||:::.:|..|.:|.  :|.::|   .||.....:|.:.||.| :||.:....|:|..
 Worm   294 ISVIPNNAFMHIPNLIRLEMSEAAVDTIER---GAFQRTPQIQAIVLNKN-RLSQVRADFFEGLN 354

  Fly   363 NILEVYMQSNS------------------------LQTLYSAQF-------PVDQLQKLYLGDNP 396
            ::..:.:|.|.                        |||:.|..|       |.|: :.:|...||
 Worm   355 DLYSIDLQGNRIDNVQPLGFANLPAISHLDISYNLLQTMPSNVFQNSFLPQPNDR-RVIYACGNP 418

  Fly   397 LQCNCSLLWLWRLVTGNFEGVDPGMEHAAGGAVAALAKEADDEELADEATAVASTDDGVAALAAY 461
            ..||..|.|...|:..|.:
 Worm   419 WYCNSELEWFRTLLRDNLD---------------------------------------------- 437

  Fly   462 IAEQHIVNALHTTEPSAYELATSSSNRNSGILRMDRQQIGCDIWRDKVRTRRKLLTMSEGE---- 522
                     :...:|....:.|||.|             ||.:....:|:........|.:
 Worm   438 ---------IDVEKPGCTAVCTSSPN-------------GCPVEGTPLRSVDFCQNNEEAQPLVG 480

  Fly   523 --ITCPAHIVTVVCAVITCLLVAMIGISVLYYLRFVKRRRK-----LLHERGPMRTSKSI----I 576
              ::....|:..|  ::|.||:::..::::.|....:|:::     ...|.....|:.||    |
 Worm   481 RALSMVGWIILAV--IMTILLISICLLAMVRYGMSHQRKKQKDAEVAAEEYHHQTTATSIYNAPI 543

  Fly   577 NVHDRILQGHNPGGLGLGMSMTL 599
            :|.||......|..|.|..:.||
 Worm   544 SVVDRPYSTVPPVNLDLPAAYTL 566

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Fili	NP_001369108.1	leucine-rich repeat	75..97	CDD:275378	0/21 (0%)
		leucine-rich repeat	98..121	CDD:275380	7/22 (32%)
		LRR_8	120..180	CDD:404697	21/61 (34%)
		leucine-rich repeat	122..145	CDD:275380	10/24 (42%)
		leucine-rich repeat	146..169	CDD:275380	7/22 (32%)
		LRR	<161..>354	CDD:227223	56/225 (25%)
		leucine-rich repeat	170..193	CDD:275380	8/25 (32%)
		leucine-rich repeat	194..217	CDD:275380	8/25 (32%)
		leucine-rich repeat	218..265	CDD:275380	8/47 (17%)
		leucine-rich repeat	266..289	CDD:275380	7/22 (32%)
		leucine-rich repeat	290..313	CDD:275380	9/46 (20%)
		leucine-rich repeat	314..338	CDD:275380	7/25 (28%)
		LRR_8	337..397	CDD:404697	19/90 (21%)
		leucine-rich repeat	339..360	CDD:275380	7/20 (35%)
lron-2	NP_505402.1	leucine-rich repeat	64..84	CDD:275380	7/22 (32%)
		leucine-rich repeat	85..109	CDD:275380	10/24 (42%)
		LRR_8	86..144	CDD:290566	20/58 (34%)
		LRR_RI	109..294	CDD:238064	44/185 (24%)
		leucine-rich repeat	110..133	CDD:275380	7/22 (32%)
		LRR_8	132..198	CDD:290566	19/65 (29%)
		leucine-rich repeat	134..157	CDD:275380	8/22 (36%)
		leucine-rich repeat	161..187	CDD:275380	8/25 (32%)
		leucine-rich repeat	188..211	CDD:275380	3/22 (14%)
		LRR_8	212..270	CDD:290566	17/58 (29%)
		leucine-rich repeat	213..235	CDD:275380	5/21 (24%)
		leucine-rich repeat	236..259	CDD:275380	7/22 (32%)
		leucine-rich repeat	260..283	CDD:275380	5/22 (23%)
		LRR_8	282..342	CDD:290566	15/63 (24%)
		leucine-rich repeat	284..307	CDD:275380	4/22 (18%)
		leucine-rich repeat	308..355	CDD:275380	15/50 (30%)
		LRR_8	330..390	CDD:290566	10/60 (17%)
		leucine-rich repeat	356..377	CDD:275380	2/20 (10%)
		leucine-rich repeat	380..400	CDD:275380	5/19 (26%)
		Ca_hom_mod	<481..>504	CDD:291464	5/24 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D187891at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.010