Protein Alignment Fili and lron-11

DIOPT Version :10

• Sequence 1: NP_001369108.1
• Gene: Fili / 5740472
• FlyBaseID: FBgn0085397
• Length: 789
• Species: Drosophila melanogaster
• Sequence 2: NP_491035.1
• Gene: lron-11 / 171837
• WormBaseID: WBGene00022129
• Length: 542
• Species: Caenorhabditis elegans
• Alignment Length: 429
• Identity: 122/429 - (28%)
• Similarity: 200/429 - (46%)
• Gaps: 47/429 - (10%)

  Fly    22 PVLLLLLLTLVILPPETTAFCPSKCQCLGGEANSRALCVDAALEDVPIQLNPETKYINLTVNRIR 86
            |||:||:|...::.      |.|.|:|   ...:.|:|..::|..:||.|:|.|..::|:.|||.
 Worm     4 PVLILLVLVSGVIS------CQSGCKC---PTKTTAVCKGSSLRSIPILLDPRTTVLDLSNNRIS 59

  Fly    87 TL---EFSLPFYMKLEILDLSQNIIETLGSKNFEYQSELRTLNLSRNLVSSLHKHAFKGLTNLLL 148
            .|   |.||  |..||.|.|..|.|..|.:..|.....||.|:||.|.:.||....|..|.||..
 Worm    60 RLSADELSL--YPNLEQLILHNNSITHLSADVFSTLPSLRVLDLSSNSLLSLPNEVFSKLKNLKT 122

  Fly   149 LDLSFNRIETVHPTALSDLASLVELDLTNNNIVSLEDNCFKGMNTLEVLVFRNNRLLDVPASNLW 213
            |.:|.|.:: :.|...:.|:.|..|.:.:|.:..|..:..|.::.|..|....|:||.:|||.:.
 Worm   123 LIISSNDVQ-LGPECFAGLSQLQTLSIADNRLSFLPPSVLKPLSGLRNLDLSANKLLSMPASVMN 186

  Fly   214 HLHALKSLDMSLNLVEFVRNDSFEGLKELLALSVQGNVMSELDLSAFEGLISLKHLDLSDNNLTM 278
            :|..|::|.:..||:..:....|...|||..|.|..|::.:::..|..||..|:.|:|::|.|..
 Worm   187 NLGGLETLKLKQNLLSSLETGMFLSQKELKHLDVSENLIGDIEEGALYGLEKLETLNLTNNQLVR 251

  Fly   279 VPTQQLS-------KLSNLTYLNLGGNRFSQLPAVAFLNLFHLRELHLSRLDFLQRIDSRAFVDN 336
            :|....|       .||:..:::|....|..|||:.:||:.|.|.        |:.|....||..
 Worm   252 LPGNTWSLPALKTLDLSSNLFVSLETASFDGLPALQYLNISHSRN--------LKTIQMATFVQL 308

  Fly   337 THLQTLHLNNNPQLSDIPMRLFQGNPNILEVYMQSNSLQTLYSAQFPVDQLQKLYLGDNPLQCNC 401
            :.|..|.:::: .|:.|....|...|.:..:.:.:|.|:.:.........::.|:|.:|...|:|
 Worm   309 SSLHWLSISSS-ALTHIHPSAFNPIPPLSHLDLSNNELRYVAPGMLQWPNIRNLHLANNDWHCSC 372

  Fly   402 SLLWLWRLVTGNFEGVDP-------GMEHAAGGAVAALA 433
            .|         ....::|       |.|:.||..:..|:
 Worm   373 DL---------RVSNLNPRDDAKCSGPENLAGAPINELS 402

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Fili	NP_001369108.1	LRR	71..>348	CDD:443914	89/286 (31%)
		leucine-rich repeat	75..97	CDD:275378	10/24 (42%)
		leucine-rich repeat	98..121	CDD:275380	8/22 (36%)
		leucine-rich repeat	122..145	CDD:275380	10/22 (45%)
		leucine-rich repeat	146..169	CDD:275380	6/22 (27%)
		leucine-rich repeat	170..193	CDD:275380	5/22 (23%)
		leucine-rich repeat	194..217	CDD:275380	9/22 (41%)
		leucine-rich repeat	218..265	CDD:275380	14/46 (30%)
		leucine-rich repeat	266..289	CDD:275380	8/29 (28%)
		leucine-rich repeat	290..313	CDD:275380	7/22 (32%)
		leucine-rich repeat	314..338	CDD:275380	5/23 (22%)
		LRR_8	337..397	CDD:404697	11/59 (19%)
		leucine-rich repeat	339..360	CDD:275380	5/20 (25%)
lron-11	NP_491035.1	LRR	33..368	CDD:443914	101/346 (29%)
		leucine-rich repeat	48..71	CDD:275380	10/24 (42%)
		leucine-rich repeat	72..95	CDD:275380	8/22 (36%)
		leucine-rich repeat	96..119	CDD:275380	10/22 (45%)
		leucine-rich repeat	120..142	CDD:275380	6/22 (27%)
		leucine-rich repeat	143..166	CDD:275380	5/22 (23%)
		leucine-rich repeat	167..190	CDD:275380	9/22 (41%)
		leucine-rich repeat	191..214	CDD:275380	5/22 (23%)
		leucine-rich repeat	215..238	CDD:275380	7/22 (32%)
		leucine-rich repeat	239..261	CDD:275380	7/21 (33%)
		leucine-rich repeat	262..283	CDD:275380	4/20 (20%)
		leucine-rich repeat	286..310	CDD:275380	8/31 (26%)
		leucine-rich repeat	311..334	CDD:275380	5/23 (22%)
		leucine-rich repeat	335..357	CDD:275380	2/21 (10%)