DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fili and Lrrn2

DIOPT Version :9

Sequence 1:	NP_001369108.1	Gene:	Fili / 5740472	FlyBaseID:	FBgn0085397	Length:	789	Species:	Drosophila melanogaster
Sequence 2:	NP_034862.1	Gene:	Lrrn2 / 16980	MGIID:	106037	Length:	730	Species:	Mus musculus

Alignment Length:	717	Identity:	165/717 - (23%)
Similarity:	269/717 - (37%)	Gaps:	185/717 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 VTATTRSRPWLCGAIPVLLLLLLTLVILPPETTAFCPSKCQC----------LGGEANSRALCVD 61
            |..||.:.|.:...:|                   ||.:|.|          ...||.: ..|.|
Mouse    13 VAGTTAAAPVVPWRVP-------------------CPPQCACQIRPWYTPRSSYREATT-VDCND 57

  Fly    62 AALEDVPIQLNPETKYINLTVNRI-RTLEFSLPFYMKLEILDLSQNIIETLGSKNFEYQSELRTL 125
            ..|..||.:|...|:.:.|..|.| |..:..|.:...|..||||||........:|:...:|.:|
Mouse    58 LFLTAVPPRLPAGTQTLLLQSNSISRIDQTELAYLANLTELDLSQNSFSDARDCDFQALPQLLSL 122

  Fly   126 NLSRNLVSSLHKHAFKGLTNLLLLDLSFNRIETVHPTALSDLASLVELDLTNNNIVSLEDNCFKG 190
            :|..|.::.|..|:|.|||:|..|.|:.|::..:.|.|.:.|.:|:.|.|.:|.:.:::...|:.
Mouse   123 HLEENRLNRLEDHSFAGLTSLQELYLNHNQLCRISPRAFAGLGNLLRLHLNSNLLRTIDSRWFEM 187

  Fly   191 MNTLEVLVFRNNRLLDVPASNLWHLHALKSLDMSLNLVEFVRNDSFEGLKELLALSVQGNVMSEL 255
            :..||:|:...|::..:             |||           :|..|..|.:|.:.|..:.|:
Mouse   188 LPNLEILMIGGNKVDAI-------------LDM-----------NFRPLANLRSLVLAGMSLREI 228

  Fly   256 DLSAFEGLISLKHLDLSDNNLTMVPTQQLSKLSNLTYLNLGGNRFSQLPAVAFLNLFHLRELHLS 320
            ...|.|||.||:.|...||.|..||.:.|.::..|.:|:|..|...::....|.|:.||:||.|:
Mouse   229 SDYALEGLQSLESLSFYDNQLAQVPKRALEQVPGLKFLDLNKNPLQRVGPGDFANMLHLKELGLN 293

  Fly   321 RLDFLQRIDSRAFVDNTHLQTLHLNNNPQLSDIPMRLFQGNPNILEVYMQSNSLQTLYSAQF-PV 384
            .::.|..||..|.|:...|..|.:.|||:||.|..|.|...|.:..:.:.:|:|..|:.... .:
Mouse   294 NMEELVSIDKFALVNLPELTKLDITNNPRLSFIHPRAFHHLPQMETLMLNNNALSALHQQTVESL 358

  Fly   385 DQLQKLYLGDNPLQCNCSLLWLWRLVTGNFEG-----VDPGMEHAAGGAVAALAKEADD------ 438
            ..||::.|..||::|:|.:.|      .|..|     ::|         .:.|..|..|
Mouse   359 PNLQEVGLHGNPIRCDCVIRW------ANATGTHVRFIEP---------QSTLCAEPPDLQRRPV 408

  Fly   439 -----EELADEATAVASTDDGVAALAAYIAEQHIVN--ALHTTEPSAYELATSSSNRNSGILRMD 496
                 .|:.|....:.|.....::|.....|..:::  ||...||..|.:..:.       :|:
Mouse   409 REVPFREMTDHCLPLISPRSFPSSLQIASGESTVLHCRALAEPEPEIYWVTPAG-------VRL- 465

  Fly   497 RQQIGCDIWRDKVRTRRKLLTMSEGEITCPAHIVTVVCAVITCLLVAMIGISVLYYLRFVKRRRK 561
                      ...|:.|:.....||.:.. ..:......:.||:...::|..
Mouse   466 ----------TPARSGRRYRVFPEGTLEL-RRVTAEEAGLYTCVAQNLVGAD------------- 506

  Fly   562 LLHERGPMRTSKSIINVHDRILQGHNPGGLGLGMSMTLGGGNHVNGLGMTLNYPHHAQTLQAHHH 626
                      :|::     .::.||.|...|           ...|.|:.|:       :|..|.
Mouse   507 ----------TKTV-----SVVVGHAPFQPG-----------RDKGPGLKLH-------VQETHP 538

  Fly   627 YH-------------------QAMPLQSHGG-------NGNHEYQQTTLPQLDKLELERYLAAQT 665
            ||                   .|..|:.|..       .|.|.|..|.|     |....|.|...
Mouse   539 YHILLFWAPPPNIVSTNLTWSSASSLRDHEAPALARLPRGTHRYNITRL-----LPATEYWACLQ 598

  Fly   666 IA 667
            :|
Mouse   599 VA 600

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fili	NP_001369108.1	leucine-rich repeat	75..97	CDD:275378	6/22 (27%)
		leucine-rich repeat	98..121	CDD:275380	8/22 (36%)
		LRR_8	120..180	CDD:404697	21/59 (36%)
		leucine-rich repeat	122..145	CDD:275380	9/22 (41%)
		leucine-rich repeat	146..169	CDD:275380	7/22 (32%)
		LRR	<161..>354	CDD:227223	57/192 (30%)
		leucine-rich repeat	170..193	CDD:275380	5/22 (23%)
		leucine-rich repeat	194..217	CDD:275380	4/22 (18%)
		leucine-rich repeat	218..265	CDD:275380	13/46 (28%)
		leucine-rich repeat	266..289	CDD:275380	8/22 (36%)
		leucine-rich repeat	290..313	CDD:275380	6/22 (27%)
		leucine-rich repeat	314..338	CDD:275380	9/23 (39%)
		LRR_8	337..397	CDD:404697	18/60 (30%)
		leucine-rich repeat	339..360	CDD:275380	10/20 (50%)
Lrrn2	NP_034862.1	leucine-rich repeat	51..69	CDD:275380	6/18 (33%)
		LRR_RI	62..288	CDD:238064	72/249 (29%)
		leucine-rich repeat	71..94	CDD:275380	6/22 (27%)
		leucine-rich repeat	95..118	CDD:275380	8/22 (36%)
		LRR_8	117..177	CDD:290566	21/59 (36%)
		leucine-rich repeat	119..142	CDD:275380	9/22 (41%)
		leucine-rich repeat	143..166	CDD:275380	7/22 (32%)
		LRR_8	166..222	CDD:290566	16/79 (20%)
		leucine-rich repeat	167..190	CDD:275380	5/22 (23%)
		leucine-rich repeat	191..214	CDD:275380	9/46 (20%)
		LRR_RI	214..>372	CDD:238064	52/157 (33%)
		LRR_8	214..273	CDD:290566	21/58 (36%)
		leucine-rich repeat	215..238	CDD:275380	8/22 (36%)
		leucine-rich repeat	239..262	CDD:275380	8/22 (36%)
		leucine-rich repeat	263..286	CDD:275380	6/22 (27%)
		leucine-rich repeat	287..311	CDD:275380	9/23 (39%)
		LRR_8	310..371	CDD:290566	18/60 (30%)
		leucine-rich repeat	312..334	CDD:275380	10/21 (48%)
		leucine-rich repeat	337..360	CDD:275378	3/22 (14%)
		leucine-rich repeat	361..373	CDD:275378	5/11 (45%)
		TPKR_C2	369..412	CDD:301599	11/57 (19%)
		I-set	430..514	CDD:254352	16/130 (12%)
		Ig	438..514	CDD:299845	15/122 (12%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8753
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24373
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.010