DRSC/TRiP Functional Genomics Resources

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Protein Alignment Fili and Lrrn1

DIOPT Version :9

Sequence 1:NP_001369108.1 Gene:Fili / 5740472 FlyBaseID:FBgn0085397 Length:789 Species:Drosophila melanogaster
Sequence 2:NP_032542.1 Gene:Lrrn1 / 16979 MGIID:106038 Length:716 Species:Mus musculus


Alignment Length:671 Identity:159/671 - (23%)
Similarity:268/671 - (39%) Gaps:102/671 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly    20 AIPVLLLLLLTLVILPPETTAFCPSKCQC-----LGGEANSRAL----CVDAALEDVPIQLNPET 75
            |..|:|.||:|.:......|:.||..|.|     ...::..|..    |.|..|..:|..|:.:|
Mouse    10 ACQVVLGLLITSLTESSILTSECPQLCVCEIRPWFTPQSTYREATTVDCNDLRLTRIPGNLSSDT 74

  Fly    76 KYINLTVNRIRTLEFSLPFYMKLEILDLSQNIIETLGSKNFEYQSELRTLNLSRNLVSSLHKHAF 140
            :.:.|..|.|......|.....|..||.|||....:........::|.||:|..|.:|.:..:..
Mouse    75 QVLLLQSNNIAKTVDELQQLFNLTELDFSQNNFTNIKEVGLANLTQLTTLHLEENQISEMTDYCL 139

  Fly   141 KGLTNLLLLDLSFNRIETVHPTALSDLASLVELDLTNNNIVSLEDNCFKGMNTLEVLVFRNNRLL 205
            :.|:||..|.::.|:|.|:...|.|.|.:|:.|.|.:|.:..::...|.....||:|:...|.::
Mouse   140 QDLSNLQELYINHNQISTISANAFSGLKNLLRLHLNSNKLKVIDSRWFDSTPNLEILMIGENPVI 204

  Fly   206 DVPASNLWHLHALKSLDMSLNLVEFVRNDSFEGLKELLALSVQGNVMSELDLSAFEGLISLKHLD 270
            .:             |||           :|..|..|.:|.:.|..::::..:|..||.||:.|.
Mouse   205 GI-------------LDM-----------NFRPLSNLRSLVLAGMYLTDVPGNALVGLDSLESLS 245

  Fly   271 LSDNNLTMVPTQQLSKLSNLTYLNLGGNRFSQLPAVAFLNLFHLRELHLSRLDFLQRIDSRAFVD 335
            ..||.|..||...|.|:.||.:|:|..|...::....|.|:..|:||.::.:..|..:|..|..:
Mouse   246 FYDNKLIKVPQLALQKVPNLKFLDLNKNPIHKIQEGDFKNMLRLKELGINNMGELVSVDRYALDN 310

  Fly   336 NTHLQTLHLNNNPQLSDIPMRLFQGNPNILEVYMQSNSLQTLYSAQF-PVDQLQKLYLGDNPLQC 399
            ...|..|...|||:||.|....|:..|.:..:.:.:|:|..:|.... .:..|:::.:..|||:|
Mouse   311 LPELTKLEATNNPKLSYIHRLAFRSVPALESLMLNNNALNAVYQKTVESLPNLREISIHSNPLRC 375

  Fly   400 NCSLLWLWRLVTGNFEGVDPGMEHAA------GGAVAALAKEADDEELADEATAVASTDDGVAAL 458
            :|.:.|:....| |...::|.....|      |..|    ||...::.:::...:.|.|.....|
Mouse   376 DCVIHWINSNKT-NIRFMEPLSMFCAMPPEYRGQQV----KEVLIQDSSEQCLPMISHDTFPNHL 435

  Fly   459 AAYIAEQHIVN--ALHTTEPSAYELATSSSNRNSGILRMDRQQIGCDIWRDKVRTRRKLLTMSEG 521
            ...|.....::  |:...||..|.:.                .||..|..:.:..:.||  .|||
Mouse   436 NMDIGTTLFLDCRAMAEPEPEIYWVT----------------PIGNKITVETLSDKYKL--SSEG 482

  Fly   522 EITCPAHIVTVVCAVITCLLVAMIGISVLYYLRFVKRRRKLLHERGPMRTSKSIINVHDRILQGH 586
            .:.. |:|........||:...:.|...         |...:...|.:.....::.::.:..:.|
Mouse   483 TLEI-ANIQIEDSGRYTCVAQNVQGADT---------RVATIKVNGTLLDGAQVLKIYVKQTESH 537

  Fly   587 NPGGLGLGMSMTLGGGNHVNGLGMTLNYPHHAQTLQ---AHHHYHQAMPLQSHGGNGNHEYQQTT 648
                     |:.:..  .||...||.|....:.|::   .|..|...:|:..      |||..|.
Mouse   538 ---------SILVSW--KVNSNVMTSNLKWSSATMKIDNPHITYTARVPVDV------HEYNLTH 585

  Fly   649 L-PQLDKLELERYLAAQTIAN 668
            | |..|      |....|::|
Mouse   586 LQPSTD------YEVCLTVSN 600

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
FiliNP_001369108.1 leucine-rich repeat 75..97 CDD:275378 5/21 (24%)
leucine-rich repeat 98..121 CDD:275380 6/22 (27%)
LRR_8 120..180 CDD:404697 20/59 (34%)
leucine-rich repeat 122..145 CDD:275380 7/22 (32%)
leucine-rich repeat 146..169 CDD:275380 8/22 (36%)
LRR <161..>354 CDD:227223 53/192 (28%)
leucine-rich repeat 170..193 CDD:275380 5/22 (23%)
leucine-rich repeat 194..217 CDD:275380 4/22 (18%)
leucine-rich repeat 218..265 CDD:275380 11/46 (24%)
leucine-rich repeat 266..289 CDD:275380 9/22 (41%)
leucine-rich repeat 290..313 CDD:275380 6/22 (27%)
leucine-rich repeat 314..338 CDD:275380 6/23 (26%)
LRR_8 337..397 CDD:404697 15/60 (25%)
leucine-rich repeat 339..360 CDD:275380 9/20 (45%)
Lrrn1NP_032542.1 LRR_RI 11..273 CDD:238064 77/285 (27%)
leucine-rich repeat 54..73 CDD:275380 5/18 (28%)
LRR 1 73..95 5/21 (24%)
leucine-rich repeat 74..96 CDD:275380 5/21 (24%)
LRR 2 96..117 6/20 (30%)
leucine-rich repeat 97..120 CDD:275380 6/22 (27%)
LRR_8 119..179 CDD:290566 20/59 (34%)
LRR 3 120..141 6/20 (30%)
leucine-rich repeat 121..144 CDD:275380 7/22 (32%)
LRR 4 144..165 7/20 (35%)
leucine-rich repeat 145..168 CDD:275380 8/22 (36%)
LRR 5 168..189 5/20 (25%)
leucine-rich repeat 169..192 CDD:275380 5/22 (23%)
LRR 6 192..213 8/44 (18%)
leucine-rich repeat 193..216 CDD:275380 9/46 (20%)
LRR_RI 211..>376 CDD:238064 48/164 (29%)
LRR_8 215..275 CDD:290566 21/59 (36%)
LRR 7 216..237 4/20 (20%)
leucine-rich repeat 217..240 CDD:275380 6/22 (27%)
LRR 8 240..261 9/20 (45%)
leucine-rich repeat 241..264 CDD:275380 9/22 (41%)
LRR_8 263..323 CDD:290566 16/59 (27%)
LRR 9 264..285 6/20 (30%)
leucine-rich repeat 265..288 CDD:275380 6/22 (27%)
leucine-rich repeat 289..313 CDD:275380 6/23 (26%)
LRR_8 312..373 CDD:290566 15/60 (25%)
leucine-rich repeat 314..335 CDD:275380 9/20 (45%)
leucine-rich repeat 339..362 CDD:275378 3/22 (14%)
leucine-rich repeat 363..375 CDD:275378 4/11 (36%)
LRRCT 371..419 CDD:214507 14/52 (27%)
I-set 429..516 CDD:254352 21/114 (18%)
Ig 431..516 CDD:299845 20/112 (18%)
fn3 531..600 CDD:278470 20/91 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 692..716
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - mtm8753
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24373
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
44.010

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