DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fili and LINGO2

DIOPT Version :9

Sequence 1:	NP_001369108.1	Gene:	Fili / 5740472	FlyBaseID:	FBgn0085397	Length:	789	Species:	Drosophila melanogaster
Sequence 2:	NP_001245211.1	Gene:	LINGO2 / 158038	HGNCID:	21207	Length:	606	Species:	Homo sapiens

Alignment Length:	399	Identity:	126/399 - (31%)
Similarity:	191/399 - (47%)	Gaps:	41/399 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 LTLVILPPETTAFCPSKCQCLGGEANSRALCVDAALEDVPIQLNPETKYINLTVNRIRTL---EF 90
            |.:|::...:|..||::|:|  ...|....|....|..:|..:..|||.::|:.||::::   ||
Human    15 LAVVLIFMGSTIGCPARCEC--SAQNKSVSCHRRRLIAIPEGIPIETKILDLSKNRLKSVNPEEF 77

  Fly    91 -SLPFYMKLEILDLSQNIIETLGSKNFEYQSELRTLNLSRNLVSSLHKHAFKGLTNLLLLDLSFN 154
             |.|.   ||.:|||.|||..:....|.....||:|.|..|.:..:....|.||:||..||:|.|
Human    78 ISYPL---LEEIDLSDNIIANVEPGAFNNLFNLRSLRLKGNRLKLVPLGVFTGLSNLTKLDISEN 139

  Fly   155 RIETVHPTALSDLASLVELDLTNNNIVSLEDNCFKGMNTLEVLVFRNNRLLDVPASNLWHLHALK 219
            :|..:......||.:|..|::.:|::|.:....|.|:.:||.|......|..||...|.||.:|.
Human   140 KIVILLDYMFQDLHNLKSLEVGDNDLVYISHRAFSGLLSLEQLTLEKCNLTAVPTEALSHLRSLI 204

  Fly   220 SLDMS-LNLVEFVRNDSFEGLKELLALSVQGNVMSELDLSAFEGLISLKHLDLSD-NNLTMVPTQ 282
            ||.:. ||:                         :.:.:.||:.|..||||::.. ..|.|:|..
Human   205 SLHLKHLNI-------------------------NNMPVYAFKRLFHLKHLEIDYWPLLDMMPAN 244

  Fly   283 QLSKLSNLTYLNLGGNRFSQLPAVAFLNLFHLRELHLSRLDFLQRIDSRAFVDNTHLQTLHLNNN 347
            .|..| |||.|::.....|.:|.:||.:|.:|..|:|| .:.:..|::..|.|...||.||: ..
Human   245 SLYGL-NLTSLSVTNTNLSTVPFLAFKHLVYLTHLNLS-YNPISTIEAGMFSDLIRLQELHI-VG 306

  Fly   348 PQLSDIPMRLFQGNPNILEVYMQSNSLQTLYSAQFPVDQ-LQKLYLGDNPLQCNCSLLW-LWRLV 410
            .||..|....|||...:..:.:..|.|:||....|...: |:.|.:.:|||.|:|.||| |.|..
Human   307 AQLRTIEPHSFQGLRFLRVLNVSQNLLETLEENVFSSPRALEVLSINNNPLACDCRLLWILQRQP 371

  Fly   411 TGNFEGVDP 419
            |..|.|..|
Human   372 TLQFGGQQP 380

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fili	NP_001369108.1	leucine-rich repeat	75..97	CDD:275378	9/25 (36%)
		leucine-rich repeat	98..121	CDD:275380	9/22 (41%)
		LRR_8	120..180	CDD:404697	20/59 (34%)
		leucine-rich repeat	122..145	CDD:275380	8/22 (36%)
		leucine-rich repeat	146..169	CDD:275380	8/22 (36%)
		LRR	<161..>354	CDD:227223	56/194 (29%)
		leucine-rich repeat	170..193	CDD:275380	6/22 (27%)
		leucine-rich repeat	194..217	CDD:275380	9/22 (41%)
		leucine-rich repeat	218..265	CDD:275380	8/47 (17%)
		leucine-rich repeat	266..289	CDD:275380	9/23 (39%)
		leucine-rich repeat	290..313	CDD:275380	8/22 (36%)
		leucine-rich repeat	314..338	CDD:275380	7/23 (30%)
		LRR_8	337..397	CDD:404697	18/60 (30%)
		leucine-rich repeat	339..360	CDD:275380	8/20 (40%)
LINGO2	NP_001245211.1	LRRNT	27..60	CDD:214470	9/34 (26%)
		leucine-rich repeat	39..57	CDD:275380	3/17 (18%)
		LRR 1	58..79		8/20 (40%)
		leucine-rich repeat	59..82	CDD:275380	8/22 (36%)
		LRR_8	60..117	CDD:316378	22/59 (37%)
		LRR 2	82..103		9/23 (39%)
		leucine-rich repeat	83..106	CDD:275380	9/22 (41%)
		LRR_8	106..165	CDD:316378	20/58 (34%)
		LRR 3	106..127		6/20 (30%)
		leucine-rich repeat	107..130	CDD:275380	8/22 (36%)
		LRR 4	130..151		7/20 (35%)
		leucine-rich repeat	131..154	CDD:275380	8/22 (36%)
		LRR_5	146..276	CDD:331043	43/155 (28%)
		LRR 5	154..175		5/20 (25%)
		leucine-rich repeat	155..178	CDD:275380	6/22 (27%)
		LRR 6	178..199		7/20 (35%)
		leucine-rich repeat	179..202	CDD:275380	9/22 (41%)
		LRR 7	202..223		7/45 (16%)
		leucine-rich repeat	203..250	CDD:275380	17/72 (24%)
		LRR 8	226..247		7/20 (35%)
		LRR_8	250..309	CDD:316378	20/60 (33%)
		LRR 9	250..271		8/20 (40%)
		leucine-rich repeat	251..274	CDD:275380	8/22 (36%)
		LRR 10	274..295		6/21 (29%)
		leucine-rich repeat	275..298	CDD:275380	7/23 (30%)
		LRR_8	298..357	CDD:316378	18/59 (31%)
		LRR 11	298..319		8/21 (38%)
		leucine-rich repeat	299..322	CDD:275380	10/23 (43%)
		LRR 12	322..343		5/20 (25%)
		leucine-rich repeat	323..343	CDD:275380	5/19 (26%)
		PCC	327..>391	CDD:188093	21/54 (39%)
		I-set	410..500	CDD:254352
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	154	1.000	Inparanoid score	I4328
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8524
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24373
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	4.060