DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fili and LRFN5

DIOPT Version :9

Sequence 1:	NP_001369108.1	Gene:	Fili / 5740472	FlyBaseID:	FBgn0085397	Length:	789	Species:	Drosophila melanogaster
Sequence 2:	NP_001333102.1	Gene:	LRFN5 / 145581	HGNCID:	20360	Length:	719	Species:	Homo sapiens

Alignment Length:	872	Identity:	169/872 - (19%)
Similarity:	274/872 - (31%)	Gaps:	337/872 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 VLLLLLLTLVILPPETTAFCPSKCQCLGGEANSRALCVDAALEDVPIQLNPETKYINLTVNRIRT 87
            :|..|.|..:.:..:   .||.:|.|.....|...||....|..||..::.            ||
Human     4 ILFYLFLIGIAVKAQ---ICPKRCVCQILSPNLATLCAKKGLLFVPPNIDR------------RT 53

  Fly    88 LEFSLPFYMKLEILDLSQNIIETLGSKNFEYQSELRTLNLSRNLVSSLHKHAFKGLTNLLLLDLS 152
            :|           |.|:.|.:..:..|:|...:.|..|.||||.:|.:..|||..|.||..|.|:
Human    54 VE-----------LRLADNFVTNIKRKDFANMTSLVDLTLSRNTISFITPHAFADLRNLRALHLN 107

  Fly   153 FNRIETVHPTALSDLASLVELDLTNNNIVSLEDNCFKGMNTLEVLVFRNNRLLDVPASNLWHLHA 217
            .||:..
Human   108 SNRLTK----------------------------------------------------------- 113

  Fly   218 LKSLDMSLNLVEFVRNDSFEGLKELLALSVQGNVMSELDLSAFEGLISLKHLDLSDNNLTMVPTQ 282
                         :.||.|.||..|..|.:..|.::.:..:||:.:.:|:.||||.|||..:|..
Human   114 -------------ITNDMFSGLSNLHHLILNNNQLTLISSTAFDDVFALEELDLSYNNLETIPWD 165

  Fly   283 QLSKLSNLTYLNLGGNRFSQLPAVAFLNLFHLRELHLSRLDFLQRIDSRAFVDNTHLQTLHLNNN 347
            .:.|:.:|..|:|..|....:|...|   .||.:  ::|||          |.:..||.|.
Human   166 AVEKMVSLHTLSLDHNMIDNIPKGTF---SHLHK--MTRLD----------VTSNKLQKLP---- 211

  Fly   348 PQLSDIPMRLFQGNPNILEVYMQSNSLQTLYSAQFPVDQLQKLYLGDNPLQCNCSLLWLWR---- 408
                  |..|||             ..|.|.::.........|..|.|||.|||.||||.|
Human   212 ------PDPLFQ-------------RAQVLATSGIISPSTFALSFGGNPLHCNCELLWLRRLSRE 257

  Fly   409 ----------LVTGNFEGVDPGME---------------------------HAAGGAVAALAKEA 436
                      |:||.:....|..|                           .|.|....|:...:
Human   258 DDLETCASPPLLTGRYFWSIPEEEFLCEPPLITRHTHEMRVLEGQRATLRCKARGDPEPAIHWIS 322

  Fly   437 DDEELADEATAVASTDDGV---------------------AALAAYIAEQHIV---------NAL 471
            .:.:|...||.....|:|.                     |..|..|.:.||:         |.:
Human   323 PEGKLISNATRSLVYDNGTLDILITTVKDTGAFTCIASNPAGEATQIVDLHIIKLPHLLNSTNHI 387

  Fly   472 HTTEPSAYELA--------TSSSN---------------------------RNSGILRMDRQQIG 501
            |..:|.:.:::        |||||                           ||...:||.:.|..
Human   388 HEPDPGSSDISTSTKSGSNTSSSNGDTKLSQDKIVVAEATSSTALLKFNFQRNIPGIRMFQIQYN 452

  Fly   502 CD-----IWRDKVRTRRKLL--TMSEGEI--TCPAHI----VTVVCA--VITCL----------- 540
            ..     ::|....|.:..|  .::.|.:  .|...|    :|.:.|  |:.|:
Human   453 GTYDDTLVYRMIPPTSKTFLVNNLAAGTMYDLCVLAIYDDGITSLTATRVVGCIQFTTEQDYVRC 517

  Fly   541 -----------LVAMIG----ISVLYYLRFVKRRRKLLHERGPMRTSKSIINVHDRILQGHNPGG 590
                       ::.:||    .|||.::..:..|.|:.:..|..:.:| :.||:.:.
Human   518 HFMQSQFLGGTMIIIIGGIIVASVLVFIIILMIRYKVCNNNGQHKVTK-VSNVYSQT-------- 573

  Fly   591 LGLGMSMTLGGGNHVNGLGMTLNYPHHAQTLQAHHHYHQAMPLQSHGGNGNHEYQQTTLPQLDKL 655
                      .|..:.|..:||               .|::..|:.|...|.:..:.|...:  :
Human   574 ----------NGAQIQGCSVTL---------------PQSVSKQAVGHEENAQCCKATSDNV--I 611

  Fly   656 ELERYLAAQTIANEYRALKP-WELPVKEADDEPEHLYERFDHYEYPDTHTMSKL---KQAASLNH 716
            :.....::|..:....||.| |......:..:......:      |.|...::.   .::.:.|.
Human   612 QSSETCSSQDSSTTTSALPPSWTSSTSVSQKQKRKTGTK------PSTEPQNEAVTNVESQNTNR 670

  Fly   717 SNSSA------GPSPVP--PSSGKPHV 735
            :||:|      .|..|.  |:|.:.|:
Human   671 NNSTALQLASRPPDSVTEGPTSKRAHI 697

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fili	NP_001369108.1	leucine-rich repeat	75..97	CDD:275378	3/21 (14%)
		leucine-rich repeat	98..121	CDD:275380	5/22 (23%)
		LRR_8	120..180	CDD:404697	17/59 (29%)
		leucine-rich repeat	122..145	CDD:275380	11/22 (50%)
		leucine-rich repeat	146..169	CDD:275380	5/22 (23%)
		LRR	<161..>354	CDD:227223	35/192 (18%)
		leucine-rich repeat	170..193	CDD:275380	0/22 (0%)
		leucine-rich repeat	194..217	CDD:275380	0/22 (0%)
		leucine-rich repeat	218..265	CDD:275380	10/46 (22%)
		leucine-rich repeat	266..289	CDD:275380	10/22 (45%)
		leucine-rich repeat	290..313	CDD:275380	6/22 (27%)
		leucine-rich repeat	314..338	CDD:275380	5/23 (22%)
		LRR_8	337..397	CDD:404697	12/59 (20%)
		leucine-rich repeat	339..360	CDD:275380	6/20 (30%)
LRFN5	NP_001333102.1	LRR 1	52..73		8/31 (26%)
		LRR 2	76..97		10/20 (50%)
		LRR 3	100..121		9/92 (10%)
		LRR 4	124..145		5/20 (25%)
		LRR 5	148..169		9/20 (45%)
		LRR 6	172..193		6/23 (26%)
		LRR 7	196..217		9/42 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	385..414		8/28 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	615..694		15/84 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910