DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fili and LRRC15

DIOPT Version :9

Sequence 1:	NP_001369108.1	Gene:	Fili / 5740472	FlyBaseID:	FBgn0085397	Length:	789	Species:	Drosophila melanogaster
Sequence 2:	NP_001128529.2	Gene:	LRRC15 / 131578	HGNCID:	20818	Length:	587	Species:	Homo sapiens

Alignment Length:	573	Identity:	142/573 - (24%)
Similarity:	230/573 - (40%)	Gaps:	105/573 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 CPSKCQCLGGEANSRALCVDAALEDVP-----------------IQLNPETKYIN---LTVNRIR 86
            |||:|.|   ...|:..|..|.:..||                 .:|| |:.::|   |...||.
Human    31 CPSECTC---SRASQVECTGARIVAVPTPLPWNAMSLQILNTHITELN-ESPFLNISALIALRIE 91

  Fly    87 TLEFS--LPFYMK----LEILDLSQNIIETLGSKNFEYQSELRTLNLSRNLVSSLHKHAFKGLTN 145
            ..|.|  .|...:    |..|.|:.|.::.|....|:....|.:|.||.|.:..:....|...:|
Human    92 KNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQIQPAHFSQCSN 156

  Fly   146 LLLLDLSFNRIETVHPTALSDLASLVELDLTNNNIVSLEDNCFKGMNTLEVLVFRNNRLLDVPAS 210
            |..|.|..|.:|.:...|...|..|.:|:|..|::..:....|:.:..|:||....|||.|:|..
Human   157 LKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLRLYENRLTDIPMG 221

  Fly   211 ------NLWHL------------------HALKSLDMSLNLVEFVRNDSFEGLKELLALSVQGNV 251
                  ||..|                  |.|:.|.:|.|.:..:....|..|.:|..|::.||.
Human   222 TFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLPPSVFMQLPQLNRLTLFGNS 286

  Fly   252 MSELDLSAFEGLISLKHLDLSDNNLTMVPTQQLSKLSNLTYLNLGGNRFSQLPAVAFLNLFHLRE 316
            :.||....|..:.:|:.|.|.||:::.:|....|.|..|..|.|..|:.|.:...||..|..|||
Human   287 LKELSPGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRE 351

  Fly   317 LHLSRLDFLQRIDSRAFVDNTHLQTLHLNNNPQLSDIPMRLFQGNPNILEVYMQSNSLQTLYSAQ 381
            |.| ..:.||.:|...|....:||.:.|.|| :|..:|..:|.....::.:.:|:|.|:.|....
Human   352 LSL-HTNALQDLDGNVFRMLANLQNISLQNN-RLRQLPGNIFANVNGLMAIQLQNNQLENLPLGI 414

  Fly   382 FP-VDQLQKLYLGDNPLQCNCSLLWL--WRLVTGNFEGVDPGMEHAAGGAVAALAKEADDEELAD 443
            |. :.:|.:|.|.|||.:|:..:|.|  |.|:                          :...|..
Human   415 FDHLGKLCELRLYDNPWRCDSDILPLRNWLLL--------------------------NQPRLGT 453

  Fly   444 EATAVASTDDGVAALAAYIAEQHI-VNALHTTE-PS-----------AYELATSSSNRNSGILRM 495
            :...|..:...|...:..|...:: |.::|..| ||           :|...||.|:.......:
Human   454 DTVPVCFSPANVRGQSLIIINVNVAVPSVHVPEVPSYPETPWYPDTPSYPDTTSVSSTTELTSPV 518

  Fly   496 DRQQIGCDIWRDKVRTRRKL--LTMSEGEITCPAHIVTVVCAVITCLLVAMIG 546
            :..   .|:...:|...|.:  :|.::..:...|.::.:|  .:.|.|.|.:|
Human   519 EDY---TDLTTIQVTDDRSVWGMTQAQSGLAIAAIVIGIV--ALACSLAACVG 566

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fili	NP_001369108.1	leucine-rich repeat	75..97	CDD:275378	7/26 (27%)
		leucine-rich repeat	98..121	CDD:275380	6/22 (27%)
		LRR_8	120..180	CDD:404697	18/59 (31%)
		leucine-rich repeat	122..145	CDD:275380	6/22 (27%)
		leucine-rich repeat	146..169	CDD:275380	7/22 (32%)
		LRR	<161..>354	CDD:227223	63/216 (29%)
		leucine-rich repeat	170..193	CDD:275380	5/22 (23%)
		leucine-rich repeat	194..217	CDD:275380	11/46 (24%)
		leucine-rich repeat	218..265	CDD:275380	13/46 (28%)
		leucine-rich repeat	266..289	CDD:275380	8/22 (36%)
		leucine-rich repeat	290..313	CDD:275380	8/22 (36%)
		leucine-rich repeat	314..338	CDD:275380	9/23 (39%)
		LRR_8	337..397	CDD:404697	18/60 (30%)
		leucine-rich repeat	339..360	CDD:275380	8/20 (40%)
LRRC15	NP_001128529.2	LRR_8	60..119	CDD:290566	14/59 (24%)
		LRR_RI	63..309	CDD:238064	63/246 (26%)
		LRR_8	88..167	CDD:290566	22/78 (28%)
		leucine-rich repeat	88..108	CDD:275380	5/19 (26%)
		leucine-rich repeat	109..156	CDD:275380	12/46 (26%)
		leucine-rich repeat	157..180	CDD:275380	7/22 (32%)
		LRR_8	180..239	CDD:290566	16/58 (28%)
		leucine-rich repeat	181..204	CDD:275380	5/22 (23%)
		leucine-rich repeat	205..228	CDD:275380	8/22 (36%)
		LRR_8	228..287	CDD:290566	14/58 (24%)
		leucine-rich repeat	229..252	CDD:275380	2/22 (9%)
		leucine-rich repeat	253..276	CDD:275380	6/22 (27%)
		leucine-rich repeat	277..300	CDD:275380	7/22 (32%)
		LRR_8	299..359	CDD:290566	21/60 (35%)
		LRR_4	299..340	CDD:289563	13/40 (33%)
		leucine-rich repeat	301..324	CDD:275380	8/22 (36%)
		LRR_4	324..364	CDD:289563	15/40 (38%)
		leucine-rich repeat	325..348	CDD:275380	8/22 (36%)
		leucine-rich repeat	349..370	CDD:275380	9/21 (43%)
		LRR_8	372..430	CDD:290566	17/58 (29%)
		leucine-rich repeat	373..393	CDD:275380	8/20 (40%)
		leucine-rich repeat	397..418	CDD:275380	5/20 (25%)
		TPKR_C2	429..>468	CDD:301599	10/64 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24373
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010