DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fili and VASN

DIOPT Version :9

Sequence 1:	NP_001369108.1	Gene:	Fili / 5740472	FlyBaseID:	FBgn0085397	Length:	789	Species:	Drosophila melanogaster
Sequence 2:	NP_612449.2	Gene:	VASN / 114990	HGNCID:	18517	Length:	673	Species:	Homo sapiens

Alignment Length:	398	Identity:	117/398 - (29%)
Similarity:	155/398 - (38%)	Gaps:	93/398 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 LCGAIPVLLLLLLTLVILPPETTAFCPSKCQCLGGEANSRALCVDAALEDVPIQLNPETKYINLT 81
            :|..:|:||.|||.|.:.|  ....|||.|||   .......|.......||..:.|:|..:.:.
Human     1 MCSRVPLLLPLLLLLALGP--GVQGCPSGCQC---SQPQTVFCTARQGTTVPRDVPPDTVGLYVF 60

  Fly    82 VNRIRTLE----FSLPFYMKLEILDLSQNIIETLGSKNFEYQSELRTLNLSRNLVSSLHKHAFKG 142
            .|.|..|:    ..||   .|::||||||.|.:|.|..|:..:.|..|:|:.|.:..:....|:|
Human    61 ENGITMLDAGSFAGLP---GLQLLDLSQNQIASLPSGVFQPLANLSNLDLTANRLHEITNETFRG 122

  Fly   143 LTNLLLLDLSFNRIETVHPTALSDLASLVELDLTNNNIVSLEDNCFKGMNTLEVLVFRNNRLLDV 207
            |..|..|.|..|||..:.|.|...|..|:||.|.:|.:.:|..             .|..|||
Human   123 LRRLERLYLGKNRIRHIQPGAFDTLDRLLELKLQDNELRALPP-------------LRLPRLL-- 172

  Fly   208 PASNLWHLHALKSLDMSLNLVEFVRNDSFEGLKELLALSVQGNVMSELDLSAFEGLISLKHLDLS 272
                        .||:|.|.: ............:.||.:.|..:.:||...|..|.:|..||:|
Human   173 ------------LLDLSHNSL-LALEPGILDTANVEALRLAGLGLQQLDEGLFSRLRNLHDLDVS 224

  Fly   273 DNNLTMVPTQQLSKLSNLTYLNLGGN-RFSQLPAVAFLNLFHLRELHLSRLDFLQRIDSRAFVDN 336
            ||.|..|| ..:..|..||.|.|.|| |.:|           ||...|:.|..||.:|    |.|
Human   225 DNQLERVP-PVIRGLRGLTRLRLAGNTRIAQ-----------LRPEDLAGLAALQELD----VSN 273

  Fly   337 THLQTLHLNNNPQLSDIPMRLFQGNPNILEVYMQSNSLQTLYSAQFPVDQLQKLYLGDNPLQCNC 401
            ..||.|                   |..|             |..||  :|:.|....||..|.|
Human   274 LSLQAL-------------------PGDL-------------SGLFP--RLRLLAAARNPFNCVC 304

  Fly   402 SLLWL--W 407
            .|.|.  |
Human   305 PLSWFGPW 312

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fili	NP_001369108.1	leucine-rich repeat	75..97	CDD:275378	6/25 (24%)
		leucine-rich repeat	98..121	CDD:275380	11/22 (50%)
		LRR_8	120..180	CDD:404697	21/59 (36%)
		leucine-rich repeat	122..145	CDD:275380	7/22 (32%)
		leucine-rich repeat	146..169	CDD:275380	9/22 (41%)
		LRR	<161..>354	CDD:227223	54/193 (28%)
		leucine-rich repeat	170..193	CDD:275380	6/22 (27%)
		leucine-rich repeat	194..217	CDD:275380	4/22 (18%)
		leucine-rich repeat	218..265	CDD:275380	11/46 (24%)
		leucine-rich repeat	266..289	CDD:275380	10/22 (45%)
		leucine-rich repeat	290..313	CDD:275380	8/23 (35%)
		leucine-rich repeat	314..338	CDD:275380	9/23 (39%)
		LRR_8	337..397	CDD:404697	11/59 (19%)
		leucine-rich repeat	339..360	CDD:275380	3/20 (15%)
VASN	NP_612449.2	LRR 8	217..238		9/21 (43%)
		leucine-rich repeat	218..240	CDD:275380	10/22 (45%)
		LRR 9	240..262		11/32 (34%)
		leucine-rich repeat	241..265	CDD:275380	12/34 (35%)
		LRR 10	265..287		11/57 (19%)
		leucine-rich repeat	266..286	CDD:275380	11/55 (20%)
		LRRCT	298..349	CDD:214507	7/15 (47%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	358..404
		EGF	409..440	CDD:278437
		fn3	466..535	CDD:278470
		LRRNT	23..54	CDD:214470	10/33 (30%)
		leucine-rich repeat	34..56	CDD:275380	5/21 (24%)
		LRR 1	52..74		5/21 (24%)
		leucine-rich repeat	57..77	CDD:275380	5/22 (23%)
		LRR_8	62..112	CDD:290566	20/52 (38%)
		LRR_4	76..117	CDD:289563	16/43 (37%)
		LRR 2	77..98		11/20 (55%)
		leucine-rich repeat	78..101	CDD:275380	11/22 (50%)
		LRR_8	101..158	CDD:290566	20/56 (36%)
		LRR_4	101..141	CDD:289563	13/39 (33%)
		LRR 3	101..122		5/20 (25%)
		leucine-rich repeat	102..125	CDD:275380	7/22 (32%)
		LRR_8	124..228	CDD:290566	36/131 (27%)
		LRR 4	125..146		8/20 (40%)
		leucine-rich repeat	126..149	CDD:275380	9/22 (41%)
		LRR 5	149..170		7/33 (21%)
		leucine-rich repeat	150..193	CDD:275380	14/70 (20%)
		LRR 6	171..191		6/34 (18%)
		LRR 7	193..214		6/20 (30%)
		leucine-rich repeat	194..217	CDD:275380	7/22 (32%)
		LRR_8	216..273	CDD:290566	26/72 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24373
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100