DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fili and CHAD

DIOPT Version :9

Sequence 1:	NP_001369108.1	Gene:	Fili / 5740472	FlyBaseID:	FBgn0085397	Length:	789	Species:	Drosophila melanogaster
Sequence 2:	XP_011522516.1	Gene:	CHAD / 1101	HGNCID:	1909	Length:	440	Species:	Homo sapiens

Alignment Length:	447	Identity:	108/447 - (24%)
Similarity:	165/447 - (36%)	Gaps:	114/447 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 PVLLLLLLTLVILPPETTAFCPSKCQCLGGEANSRALCVDAALEDVPIQLNPETKYINLTVNRIR 86
            |:|||.|..|..|.|...| ||..|.|  .......:|....|:.:| :::.:||
Human    85 PMLLLSLGLLAGLLPALAA-CPQNCHC--HSDLQHVICDKVGLQKIP-KVSEKTK---------- 135

  Fly    87 TLEFSLPFYMKLEILDLSQNIIETLGSKNFEYQSELRTLNLSRNLVSSLHKHAFKGLTNLLLLDL 151
                         :|:|.:|....|.:.:|.....|.:|:|....:..:...||:||..|:.|.|
Human   136 -------------LLNLQRNNFPVLAANSFRAMPNLVSLHLQHCQIREVAAGAFRGLKQLIYLYL 187

  Fly   152 SFNRIETVHPTALSDLASLVELDLTNNNIVSLEDNCFKGMNTLEVLVFRNNRLLDVPASNLWHLH 216
            |.|.|..:...|..||..|..|.|.:|.:..|.......:..|.:|...||::.:
Human   188 SHNDIRVLRAGAFDDLTELTYLYLDHNKVTELPRGLLSPLVNLFILQLNNNKIRE---------- 242

  Fly   217 ALKSLDMSLNLVEFVRNDSFEGLKELLALSVQGNVMSELDLSAFEGLISLKHLDLSDNNLTMVPT 281
                          :|..:|:|.|:|..|.:..|.:|.|...|.:.:.:|....:..|.|:..|:
Human   243 --------------LRAGAFQGAKDLRWLYLSENALSSLQPGALDDVENLAKFHVDRNQLSSYPS 293

  Fly   282 QQLSKLSNLTYLNLGGNRFSQLPAVAFLNL-FHLRELHLSRLDFLQRIDSRAFVDNTHLQTLHLN 345
            ..||||..:..|.|..|....:|..||.:. .:|..|.|...: |::....||:..|.|:.:||.
Human   294 AALSKLRVVEELKLSHNPLKSIPDNAFQSFGRYLETLWLDNTN-LEKFSDGAFLGVTTLKHVHLE 357

  Fly   346 NNPQLSDIPMRLFQGNPNILEVYMQSNSLQTLYSAQFPVDQLQKLYLGDNPLQCNCSLLWLWRLV 410
            || :|:.:|                         :.||.|.|:.|.|.:||.:|.|.|..|.|.:
Human   358 NN-RLNQLP-------------------------SNFPFDSLETLALTNNPWKCTCQLRGLRRWL 396

  Fly   411 TGNFEGVDPGMEHAAGGAVAALAKEADDEELADEATAVASTDDGVAALAAYIAEQHI 467
                                               .|.||..|...|..|....|||
Human   397 -----------------------------------EAKASRPDATCASPAKFKGQHI 418

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fili	NP_001369108.1	leucine-rich repeat	75..97	CDD:275378	2/21 (10%)
		leucine-rich repeat	98..121	CDD:275380	5/22 (23%)
		LRR_8	120..180	CDD:404697	20/59 (34%)
		leucine-rich repeat	122..145	CDD:275380	7/22 (32%)
		leucine-rich repeat	146..169	CDD:275380	9/22 (41%)
		LRR	<161..>354	CDD:227223	49/193 (25%)
		leucine-rich repeat	170..193	CDD:275380	5/22 (23%)
		leucine-rich repeat	194..217	CDD:275380	4/22 (18%)
		leucine-rich repeat	218..265	CDD:275380	10/46 (22%)
		leucine-rich repeat	266..289	CDD:275380	8/22 (36%)
		leucine-rich repeat	290..313	CDD:275380	6/23 (26%)
		leucine-rich repeat	314..338	CDD:275380	6/23 (26%)
		LRR_8	337..397	CDD:404697	15/59 (25%)
		leucine-rich repeat	339..360	CDD:275380	7/20 (35%)
CHAD	XP_011522516.1	LRRNT	104..130	CDD:279764	7/28 (25%)
		leucine-rich repeat	134..157	CDD:275380	7/45 (16%)
		LRR_8	156..216	CDD:290566	20/59 (34%)
		leucine-rich repeat	158..181	CDD:275380	7/22 (32%)
		LRR_RI	<171..363	CDD:238064	59/217 (27%)
		leucine-rich repeat	182..205	CDD:275380	9/22 (41%)
		LRR_8	204..264	CDD:290566	16/83 (19%)
		leucine-rich repeat	206..229	CDD:275380	5/22 (23%)
		leucine-rich repeat	230..253	CDD:275380	7/46 (15%)
		leucine-rich repeat	254..277	CDD:275380	6/22 (27%)
		leucine-rich repeat	278..301	CDD:275380	8/22 (36%)
		LRR_8	302..361	CDD:290566	18/60 (30%)
		leucine-rich repeat	302..325	CDD:275380	6/22 (27%)
		leucine-rich repeat	327..350	CDD:275380	6/23 (26%)
		leucine-rich repeat	351..373	CDD:275380	10/47 (21%)
		LRRCT	381..428	CDD:214507	16/73 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24373
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010