DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fili and LRRC17

DIOPT Version :9

Sequence 1:	NP_001369108.1	Gene:	Fili / 5740472	FlyBaseID:	FBgn0085397	Length:	789	Species:	Drosophila melanogaster
Sequence 2:	NP_001026862.1	Gene:	LRRC17 / 10234	HGNCID:	16895	Length:	441	Species:	Homo sapiens

Alignment Length:	405	Identity:	101/405 - (24%)
Similarity:	172/405 - (42%)	Gaps:	81/405 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    76 KYINLTVNRIRTLEFSLPFYMK--LEILDLSQNIIETLGSKNFEYQSELRTLNLSRNLVSSLHKH 138
            ||::.   :.|.|.:.||.:.:  |.:| |::|.|.||.:..|....:|::|:|.:|.:|.:...
Human    63 KYLDC---QERKLVYVLPGWPQDLLHML-LARNKIRTLKNNMFSKFKKLKSLDLQQNEISKIESE 123

  Fly   139 AFKGLTNLLLLDLSFNRIET------VHPTALSDLASLVELDLTNNNIVSLEDNCFKGMNTLEVL 197
            ||.||..|..|.|..|:|:.      ::...||.|              .|.||.:.....:|.|
Human   124 AFFGLNKLTTLLLQHNQIKVLTEEVFIYTPLLSYL--------------RLYDNPWHCTCEIETL 174

  Fly   198 VFRNNRLLDVPAS-NLWHLHALKSLDMSLN-LVEFVRNDSF--EGLKELL--ALSVQGN---VMS 253
            :    .:|.:|.: ||.:....:|.....| .:..::::..  |..||.|  ...|.|.   :..
Human   175 I----SMLQIPRNRNLGNYAKCESPQEQKNKKLRQIKSEQLCNEEEKEQLDPKPQVSGRPPVIKP 235

  Fly   254 ELDLSAF--EGLISLKHLDLSDNNLTMVPTQQLSKLSNLTYLNLGGNRFSQLPAVAFLNLFHLRE 316
            |:| |.|  ..:..::.||.....|..||.   :...::..|:|..|:.:||....|.::..|::
Human   236 EVD-STFCHNYVFPIQTLDCKRKELKKVPN---NIPPDIVKLDLSYNKINQLRPKEFEDVHELKK 296

  Fly   317 LHLSRLDFLQRIDSRAFVDNTHLQTLHLNNNPQLSDIPMRLFQGNPNILEVYMQSNSLQTL-YSA 380
            |:||. :.::.||..||:..|||:.|.|:|                         ||||.. |..
Human   297 LNLSS-NGIEFIDPAAFLGLTHLEELDLSN-------------------------NSLQNFDYGV 335

  Fly   381 QFPVDQLQKLYLGDNPLQCNCSL----LWLWRLVTGNFEGVD---PGMEHAAGGAVAALAKEADD 438
            ...:..|:.|:|.|||.:|:.::    .||......:|.|::   |  |...|.:|....:...:
Human   336 LEDLYFLKLLWLRDNPWRCDYNIHYLYYWLKHHYNVHFNGLECKTP--EEYKGWSVGKYIRSYYE 398

  Fly   439 EELADEATAVASTDD 453
            |...|:..|...:.|
Human   399 ECPKDKLPAYPESFD 413

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fili	NP_001369108.1	leucine-rich repeat	75..97	CDD:275378	6/20 (30%)
		leucine-rich repeat	98..121	CDD:275380	8/22 (36%)
		LRR_8	120..180	CDD:404697	17/65 (26%)
		leucine-rich repeat	122..145	CDD:275380	9/22 (41%)
		leucine-rich repeat	146..169	CDD:275380	8/28 (29%)
		LRR	<161..>354	CDD:227223	49/203 (24%)
		leucine-rich repeat	170..193	CDD:275380	3/22 (14%)
		leucine-rich repeat	194..217	CDD:275380	6/23 (26%)
		leucine-rich repeat	218..265	CDD:275380	12/56 (21%)
		leucine-rich repeat	266..289	CDD:275380	5/22 (23%)
		leucine-rich repeat	290..313	CDD:275380	6/22 (27%)
		leucine-rich repeat	314..338	CDD:275380	8/23 (35%)
		LRR_8	337..397	CDD:404697	16/60 (27%)
		leucine-rich repeat	339..360	CDD:275380	4/20 (20%)
LRRC17	NP_001026862.1	leucine-rich repeat	63..81	CDD:275380	6/20 (30%)
		LRR 1	82..103		8/21 (38%)
		LRR_8	84..141	CDD:290566	21/57 (37%)
		leucine-rich repeat	84..106	CDD:275380	8/22 (36%)
		LRR_4	105..146	CDD:289563	14/40 (35%)
		LRR 2	106..127		7/20 (35%)
		leucine-rich repeat	107..130	CDD:275380	9/22 (41%)
		LRR 3	130..151		5/20 (25%)
		leucine-rich repeat	131..154	CDD:275380	5/22 (23%)
		leucine-rich repeat	155..244	CDD:275380	24/107 (22%)
		leucine-rich repeat	249..269	CDD:275380	5/22 (23%)
		LRR_RI	<267..>351	CDD:238064	29/109 (27%)
		LRR 4	269..290		6/20 (30%)
		leucine-rich repeat	270..293	CDD:275380	6/22 (27%)
		LRR_8	272..328	CDD:290566	21/81 (26%)
		LRR 5	293..314		8/21 (38%)
		LRR_4	294..332	CDD:289563	18/63 (29%)
		leucine-rich repeat	294..317	CDD:275380	8/23 (35%)
		LRR 6	317..340		10/47 (21%)
		leucine-rich repeat	318..341	CDD:275380	9/47 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24373
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100