DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fili and lrrn3a

DIOPT Version :9

Sequence 1:	NP_001369108.1	Gene:	Fili / 5740472	FlyBaseID:	FBgn0085397	Length:	789	Species:	Drosophila melanogaster
Sequence 2:	XP_005163128.1	Gene:	lrrn3a / 101887059	ZFINID:	ZDB-GENE-061220-7	Length:	691	Species:	Danio rerio

Alignment Length:	642	Identity:	150/642 - (23%)
Similarity:	264/642 - (41%)	Gaps:	117/642 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 AIPVLLLLLLTLVILPPETTAFCPSKCQC----------LGGEANSRALCVDAALEDVPIQLNPE 74
            |:.:|..|.||..:...:.:..|...|:|          :..||.: ..|.|..|..:|.:|..:
Zfish     7 AVCLLAGLALTNSVQASKWSVVCLKLCKCEIRPWFSPLSMYNEAPT-VDCNDLGLLTLPERLPSD 70

  Fly    75 TKYINLTVNRIRTLEFSLPFYMKLEILDLSQNIIETLGSKNFEYQSELRTLNLSRNLVSSLHKHA 139
            |:.:....|.|..::..|.:.:.|..:|||:|.|.:|......:..:|.:|:|..|.:||||.:.
Zfish    71 TQVLLSQANSIAKIDSPLDYLVNLTEVDLSRNNISSLSDIYIGHIPQLLSLHLEENWLSSLHDNF 135

  Fly   140 FKGLTNLLLLDLSFNRIETVHPTALSDLASLVELDLTNNNIVSLEDNCFKGMNTLEVLVFRNNRL 204
            .....||..|.::.|.:..:...|...|..|:.|.|.:|.:.::....|:.::.||:|:...|
Zfish   136 LAHFPNLQELYVNHNLLSLISAEAFQGLNKLLRLHLNSNQLRAIRSEWFQDLSQLEILMIGEN-- 198

  Fly   205 LDVPASNLWHLHALKSLDMSLNLVEFVRNDSFEGLKELLALSVQGNVMSELDLSAFEGLISLKHL 269
               |.:.                   ::|.:|:.|..|.:|.:....::|:..||..||..|:.:
Zfish   199 ---PIAR-------------------IQNMNFKPLINLRSLVLTRMNLTEIPDSALVGLDKLESV 241

  Fly   270 DLSDNNLTMVPTQQLSKLSNLTYLNLGGNRFSQLPAVAFLNLFHLRELHLSRLDFLQRIDSRAFV 334
            ...||....||...|.::.||.:|:|..|...::....|:::.||:||.::.:..|..|||.|..
Zfish   242 SFYDNMFPKVPQAALRQVRNLKFLDLNKNPIERIQRGDFVDMIHLKELGINSMPELVSIDSFALH 306

  Fly   335 DNTHLQTLHLNNNPQLSDIPMRLFQGNPNILEVYMQSNSLQTLYSAQF-PVDQLQKLYLGDNPLQ 398
            :...|..:...|||:||.|....|...|.:..:.:.||:|:.|:.... .:..||::.:..||:.
Zfish   307 NLPELTKIEATNNPRLSYIHPNAFSQLPRLESLMLNSNALRALHHITVESLPNLQEVSIHSNPIY 371

  Fly   399 CNCSLLWL-------------WRLVTG--NFEGVDPGMEHAAGGAVAALAKEADDEELADEATAV 448
            |:|.:.|:             ..|..|  .|||              .|.|:....|:||....:
Zfish   372 CDCVIRWINMNNTRVRFMELDALLCAGPSEFEG--------------RLVKQVHSREMADICLPL 422

  Fly   449 ASTD---DGVAALAAYIAEQHIVNALHTTEPSAYELATSSSNRNSGIL-RMDRQQIGC------D 503
            .|.:   |.|.....::...| ..|....||..|.:..|...    || :||.::...      |
Zfish   423 ISPESLPDQVNVGTGHLVSLH-CRAFADPEPEIYWVTPSGEK----ILPQMDSKKYHLHPEGTFD 482

  Fly   504 IWRDKVRTRRKLLTMSE-GEITCPAHIVTVVCAVITCLLVAMIGISVLYYLRFVKRRRKLLHERG 567
            |:.         :|.:| |:.||.||  .::...:..:||.:.|    ||
Zfish   483 IYG---------ITENEAGQYTCVAH--NLIGVDMRSVLVIVNG----YY--------------- 517

  Fly   568 PMRTSKSIINVHDRILQGHNPGGLGLGMSMTLGGGNHVNGLGMTLNYPHHAQTLQAH 624
            |:..::|:   |   :|..|.....:.:|.....|:.|:.:..:.|..||:....:|
Zfish   518 PLLVNESL---H---IQVENTEPNSVSISWVPPKGSLVSNIKWSTNSQHHSLQFTSH 568

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fili	NP_001369108.1	leucine-rich repeat	75..97	CDD:275378	4/21 (19%)
		leucine-rich repeat	98..121	CDD:275380	7/22 (32%)
		LRR_8	120..180	CDD:404697	18/59 (31%)
		leucine-rich repeat	122..145	CDD:275380	8/22 (36%)
		leucine-rich repeat	146..169	CDD:275380	5/22 (23%)
		LRR	<161..>354	CDD:227223	49/192 (26%)
		leucine-rich repeat	170..193	CDD:275380	5/22 (23%)
		leucine-rich repeat	194..217	CDD:275380	5/22 (23%)
		leucine-rich repeat	218..265	CDD:275380	10/46 (22%)
		leucine-rich repeat	266..289	CDD:275380	6/22 (27%)
		leucine-rich repeat	290..313	CDD:275380	5/22 (23%)
		leucine-rich repeat	314..338	CDD:275380	8/23 (35%)
		LRR_8	337..397	CDD:404697	16/60 (27%)
		leucine-rich repeat	339..360	CDD:275380	8/20 (40%)
lrrn3a	XP_005163128.1	LRR_RI	29..>272	CDD:238064	66/267 (25%)
		leucine-rich repeat	52..70	CDD:275380	5/18 (28%)
		leucine-rich repeat	71..93	CDD:275380	4/21 (19%)
		leucine-rich repeat	94..117	CDD:275380	7/22 (32%)
		leucine-rich repeat	118..141	CDD:275380	8/22 (36%)
		LRR_8	140..200	CDD:290566	15/64 (23%)
		leucine-rich repeat	142..165	CDD:275380	5/22 (23%)
		leucine-rich repeat	166..189	CDD:275380	5/22 (23%)
		leucine-rich repeat	190..213	CDD:275380	8/46 (17%)
		LRR_8	213..272	CDD:290566	18/58 (31%)
		leucine-rich repeat	214..237	CDD:275380	7/22 (32%)
		leucine-rich repeat	238..261	CDD:275380	6/22 (27%)
		leucine-rich repeat	262..285	CDD:275380	5/22 (23%)
		leucine-rich repeat	286..310	CDD:275380	8/23 (35%)
		LRR_8	309..370	CDD:290566	16/60 (27%)
		leucine-rich repeat	311..333	CDD:275380	8/21 (38%)
		leucine-rich repeat	336..359	CDD:275378	4/22 (18%)
		leucine-rich repeat	360..372	CDD:275378	4/11 (36%)
		LRRCT	368..412	CDD:214507	12/57 (21%)
		IG_like	429..513	CDD:214653	23/99 (23%)
		Ig	437..513	CDD:299845	21/91 (23%)
		FN3	526..>591	CDD:238020	10/46 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm6470
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.910