DRSC/TRiP Functional Genomics Resources

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Protein Alignment Fili and cd180

DIOPT Version :10

Sequence 1:NP_001369108.1 Gene:Fili / 5740472 FlyBaseID:FBgn0085397 Length:789 Species:Drosophila melanogaster
Sequence 2:NP_001297419.2 Gene:cd180 / 101885327 ZFINID:ZDB-GENE-070705-323 Length:665 Species:Danio rerio


Alignment Length:643 Identity:148/643 - (23%)
Similarity:245/643 - (38%) Gaps:190/643 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly    22 PVLLLLLLT---LVILPPETTAFCPSKCQCLGGEANSRALCVDAALEDVPIQLNPETKYINLTVN 83
            |.|.:||||   ||.:  .:|||                        ..|:.|    ||::|..:
Zfish   103 PHLEVLLLTGNPLVFI--ASTAF------------------------SGPLAL----KYLSLVQS 137

  Fly    84 RIRTLEFSLPF--YMKLEILDLSQNIIETL-GSKNFEYQSELRTLNLSRNLVSSLHKHAFKGLTN 145
            :|:.|. .:|.  ...||:|||..:.|.:| |..||.:|: |::|.|..|.:..:..:..:..:|
Zfish   138 KIKQLS-DIPSENLAYLEVLDLRGSNIRSLDGLSNFRWQN-LKSLQLDLNFIDRISFNDLQPFSN 200

  Fly   146 LLLLDLSF--NRIETVHPTALSDLASLVELD----LTNNNIVSLEDNCFKGMNTLEVLVFRNNRL 204
            |..:.:||  |....:.|.|...| :|..||    |...||.||    .||:..:     :.|||
Zfish   201 LAGVSISFKGNDFIYIEPGAFHSL-NLSSLDFSGCLNKMNISSL----LKGLEGI-----KTNRL 255

  Fly   205 ---LDVPASNLWHLH-ALKSL------DMSLNLVEF--VRNDSFEGLKELLALSVQGNVMSELDL 257
               |....||::... ||:|.      |:...|..|  :.|.:|..|:.|..|.:....::.|.|
Zfish   256 NLGLYETDSNVYIASAALQSFCNIFVSDLDFQLQHFLDLNNSTFHCLEGLKKLDLTRAHLNALPL 320

  Fly   258 SAFEGLISLKHLDLSDNNLTMVPTQQLSKLSNLTYLNLGGNRFSQLPAVAFLN------------ 310
            :. .||.:|.||.|.:|....|..........||:|::.||    |..:.|.|            
Zfish   321 NT-TGLSTLSHLILDENQFKDVCQSNTRNFPMLTHLSISGN----LKKLTFSNRCLDSLGLLEEL 380

  Fly   311 -----------------LFHLREL----------------------HLSRLDFLQRI-----DSR 331
                             ||.|.||                      .|..|||...:     ||.
Zfish   381 DLSVSLVNPREPCCNNQLFGLGELKLLNLSYGSPMFWSSKPFNVTPKLEHLDFSHSVYTLMNDSS 445

  Fly   332 AFVDNTHLQTLHLN-NNPQLSDIPMRLFQGNPNILEVYMQSNSLQTLYSAQFP----VDQLQKLY 391
            .|.:...|:||:|: :|..|:::  .||.|...:..:.::.|::|.....|..    |..|:.|.
Zfish   446 PFSNLQSLRTLNLSWSNTDLTNV--HLFVGLKALQHLNLRGNAIQGEVLTQTELFKCVPLLETLV 508

  Fly   392 LGDNPLQCNCSLLWLWRLVTGNFEGVDPGMEHAAGGAVAALAKEADDEELADEATAVASTDDGVA 456
            |.    .|.         :|...|.:..|:.|            .:..:|::......|| .|..
Zfish   509 LS----ACK---------ITSFDENLFKGLRH------------LNHIDLSENKFVKLST-SGFY 547

  Fly   457 ALAAYIAEQHIVNALHTTEPSAYELATSSSNRNSGILRMDRQQIGCDI-------W--RDKVRTR 512
            :| .::......|.:.|.     ::|:.:.....|.:.:....:.|:.       |  ::||:.:
Zfish   548 SL-DFLKLNFARNDITTV-----DVASVADLGEEGSVDLSYNPLVCNCSNFEFIHWVKKNKVKVK 606

  Fly   513 RKLLT--------MSEGEITCPAHI-VTVVCAVITCLLVAMIGISVLYYLRFVKRRRK 561
            ..:.|        :.:.::.|...: |.|.|||:..:|:|    |.::.|  |:|.||
Zfish   607 HLMETFCNRTGTRIIDAKLQCDLPVGVLVFCAVLAAVLLA----SAIFLL--VRRVRK 658

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
FiliNP_001369108.1 LRR 71..>348 CDD:443914 91/354 (26%)
leucine-rich repeat 75..97 CDD:275378 6/23 (26%)
leucine-rich repeat 98..121 CDD:275380 11/23 (48%)
leucine-rich repeat 122..145 CDD:275380 4/22 (18%)
leucine-rich repeat 146..169 CDD:275380 7/24 (29%)
leucine-rich repeat 170..193 CDD:275380 10/26 (38%)
leucine-rich repeat 194..217 CDD:275380 6/26 (23%)
leucine-rich repeat 218..265 CDD:275380 14/54 (26%)
leucine-rich repeat 266..289 CDD:275380 6/22 (27%)
leucine-rich repeat 290..313 CDD:275380 9/51 (18%)
leucine-rich repeat 314..338 CDD:275380 10/50 (20%)
LRR_8 337..397 CDD:404697 16/64 (25%)
leucine-rich repeat 339..360 CDD:275380 8/21 (38%)
cd180NP_001297419.2 None

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