DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fili and Chadl

DIOPT Version :9

Sequence 1:	NP_001369108.1	Gene:	Fili / 5740472	FlyBaseID:	FBgn0085397	Length:	789	Species:	Drosophila melanogaster
Sequence 2:	XP_038936217.1	Gene:	Chadl / 100910434	RGDID:	6504353	Length:	747	Species:	Rattus norvegicus

Alignment Length:	749	Identity:	177/749 - (23%)
Similarity:	262/749 - (34%)	Gaps:	219/749 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MPDHTRVTATTRSRPWLCGAIPVLLLLLLTLVILPPETTAF--CPSKCQCLGGEANSR--ALCVD 61
            || |.:..:.:..||      ....||||.:.:.|....|.  ||..|.|    .|||  ..|..
  Rat     1 MP-HGQQLSLSSPRP------QSFTLLLLMMFLSPAWNVAAQRCPQTCVC----DNSRRHVTCQH 54

  Fly    62 AALEDVPIQLNPETKYINLTVNRIRTLEFSLPFYMKLEILDLSQNIIETLGSKNFEYQSELRTLN 126
            ..|.:||..: ||     ||                 :.|||..|:::.:....|:....|..|:
  Rat    55 QNLTEVPDTI-PE-----LT-----------------QRLDLQGNMLKVIPPAAFQDLPYLTHLD 96

  Fly   127 LSRNLVSSLHKHAFKGLTNLLLLDLSFNRIETVHPTALSDLASLVELDLTNNNIVSLEDNCFKGM 191
            |....|..:.:.||:||..||.|:|:.||:.::...||..|.||..|:|..|.:..|....|..:
  Rat    97 LQHCQVEQVAEGAFRGLGRLLFLNLASNRLSSLPQEALDGLGSLRRLELERNMLEELRPGTFGAL 161

  Fly   192 NTLEVLVFRNNRLLDVPASNLWHLHALKSLDMSLNLVEFVRNDSFEGLKELLALSVQGNVMSELD 256
            .:|..|...:|.|:.:||.                        :|:||.....|.:..|.:|.|.
  Rat   162 GSLATLNLAHNALVYLPAM------------------------AFQGLMRTRWLQLSHNALSVLA 202

  Fly   257 LSAFEGLISLKHLDLSDNNLTMVPTQQLSKLSNLTYLNLGGNRFSQLPAVAFLNLFHLRELHLSR 321
            ..|..||..|:.|.|..|.|..:|...||:..:|..|.||.|..:.......|.|..||||.|..
  Rat   203 PEALAGLPVLRRLSLHHNELQALPGAALSQARSLARLELGHNPLTYTGEEDGLALPGLRELALDH 267

  Fly   322 LDFLQRIDSRAFVDNTHLQTLHLNNNPQLSDIPMRLFQGNPNILEVYMQSNSLQTLYSAQFPVDQ 386
             ..||.:..|||.....|.||.|                         :.|.|.||...|.| .|
  Rat   268 -GSLQALGPRAFAHCPRLHTLDL-------------------------RGNQLTTLPPLQVP-GQ 305

  Fly   387 LQKLYLGDNPLQCNCS----LLWLWRLVTGNFEGVDPGMEHAAGGAVAAL----------AKEAD 437
            |::|.|..|||.|.|.    |.||.|....: :|...|.....|..:..|          |.|.:
  Rat   306 LRRLRLQGNPLWCACHARPLLEWLVRARVRS-DGACRGPRRLRGETLDTLRPSDLRCPGDAAEDE 369

  Fly   438 DEE-----------LADEA---------------TAVASTDD-GVAAL----------------- 458
            ||:           |.:||               |..::.|. |:.|:
  Rat   370 DEDRPAGPRSPPRSLHEEARWATPCPPACVCVGETRHSACDGRGLQAVPRGFPNDTQLLDLRRNH 434

  Fly   459 ------AAYIAEQHIVNALHTTEPSAYELATSSSNRNSGILRMDRQQIGCDIWRDKVRTRRKLLT 517
                  ||:...:|:| :||.......||...:.....|::                     .|.
  Rat   435 FPSVPRAAFPGLRHLV-SLHLQHCGIAELEPGALAGLDGLV---------------------YLY 477

  Fly   518 MSEGEITCPAHIVTVVCAVITCLLVAMIGISVLYYLRFVKRRRKLLHERGPMRTSKSIINVH--- 579
            :|..:::             .....|:.|...|.|| :::..|.|......:|....:.::|
  Rat   478 LSNNQLS-------------GLSAAALEGAPNLGYL-YLEHNRFLRIPGAALRALPRLFSLHLQD 528

  Fly   580 ---DRILQGHNPGGLGL-GMSMTLGGGNHVNGLGM-TLNYPHHAQTLQAHHHYHQAMPLQSHGGN 639
               ||:..|...|...| |:.::   |||:..:.. .|......:.|....:..:.:|..:..|
  Rat   529 NAVDRLAPGDLAGARALRGLYLS---GNHITQVSPGALGPARELEKLHLDRNQLRQVPTGALEG- 589

  Fly   640 GNHEYQQTTLPQLDKLELERYLAAQTIANEYRAL 673
                     ||.|.:|:|.|        |.:|||
  Rat   590 ---------LPALKELQLSR--------NPFRAL 606

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fili	NP_001369108.1	leucine-rich repeat	75..97	CDD:275378	2/21 (10%)
		leucine-rich repeat	98..121	CDD:275380	5/22 (23%)
		LRR_8	120..180	CDD:404697	22/59 (37%)
		leucine-rich repeat	122..145	CDD:275380	8/22 (36%)
		leucine-rich repeat	146..169	CDD:275380	9/22 (41%)
		LRR	<161..>354	CDD:227223	55/192 (29%)
		leucine-rich repeat	170..193	CDD:275380	6/22 (27%)
		leucine-rich repeat	194..217	CDD:275380	6/22 (27%)
		leucine-rich repeat	218..265	CDD:275380	10/46 (22%)
		leucine-rich repeat	266..289	CDD:275380	8/22 (36%)
		leucine-rich repeat	290..313	CDD:275380	7/22 (32%)
		leucine-rich repeat	314..338	CDD:275380	10/23 (43%)
		LRR_8	337..397	CDD:404697	15/59 (25%)
		leucine-rich repeat	339..360	CDD:275380	4/20 (20%)
Chadl	XP_038936217.1	PLN00113	30..>555	CDD:215061	152/642 (24%)
		leucine-rich repeat	48..66	CDD:275380	4/18 (22%)
		leucine-rich repeat	68..91	CDD:275380	6/39 (15%)
		leucine-rich repeat	92..115	CDD:275380	8/22 (36%)
		leucine-rich repeat	116..139	CDD:275380	9/22 (41%)
		leucine-rich repeat	140..163	CDD:275380	6/22 (27%)
		leucine-rich repeat	164..187	CDD:275380	9/46 (20%)
		leucine-rich repeat	188..211	CDD:275380	7/22 (32%)
		leucine-rich repeat	212..235	CDD:275380	8/22 (36%)
		leucine-rich repeat	236..259	CDD:275380	7/22 (32%)
		leucine-rich repeat	260..283	CDD:275380	10/23 (43%)
		leucine-rich repeat	306..345	CDD:275380	14/39 (36%)
		leucine-rich repeat	425..448	CDD:275380	2/22 (9%)
		PPP1R42	446..603	CDD:411060	38/213 (18%)
		leucine-rich repeat	449..472	CDD:275380	5/23 (22%)
		leucine-rich repeat	473..496	CDD:275380	4/56 (7%)
		leucine-rich repeat	497..520	CDD:275380	6/23 (26%)
		leucine-rich repeat	521..544	CDD:275380	5/22 (23%)
		leucine-rich repeat	545..568	CDD:275380	6/25 (24%)
		leucine-rich repeat	569..592	CDD:275380	4/32 (13%)
		LRR_8	591..653	CDD:404697	9/24 (38%)
		leucine-rich repeat	593..617	CDD:275380	8/22 (36%)
		leucine-rich repeat	618..641	CDD:275380
		leucine-rich repeat	643..665	CDD:275380
		leucine-rich repeat	666..677	CDD:275378
		LRRCT	673..721	CDD:214507
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24373
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.010