DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fili and lrrc4bb

DIOPT Version :9

Sequence 1:	NP_001369108.1	Gene:	Fili / 5740472	FlyBaseID:	FBgn0085397	Length:	789	Species:	Drosophila melanogaster
Sequence 2:	XP_003201401.1	Gene:	lrrc4bb / 100535350	ZFINID:	ZDB-GENE-091116-44	Length:	726	Species:	Danio rerio

Alignment Length:	860	Identity:	192/860 - (22%)
Similarity:	297/860 - (34%)	Gaps:	279/860 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 PVLLLLLLTLVILP-------PETTAFCPSKCQCLGGEANSRALCVDAALEDVPIQLNPETKYIN 79
            |..|:.|:.|::.|       .|.:..||:.|.|  ....||.:|...:|.:||..::..|:|:|
Zfish    12 PSPLIWLVQLLLWPHLLGPRLAEASPACPALCSC--SNQASRVICTKKSLNEVPQSISSNTRYLN 74

  Fly    80 LTVNRIRTLEFSLPFYMKLEILDLSQNIIETLGSKNFEYQSELRTLNLSRNLVSSLHKHAFKGLT 144
                                   |.:|.|:.:.|..|::.:.|..|.||:|.:..:...||.||.
Zfish    75 -----------------------LQENSIQVIRSDTFKHLNHLEILQLSKNQIRQIEVGAFNGLP 116

  Fly   145 NLLLLDLSFNRIETVHPTALSDLASLVELDLTNNNIVSLEDNCFKGMNTLEVLVFRNNRLLDVPA 209
            ||:.|:|..||:..|...|...|:.|.||.|.||.|.:|                        ||
Zfish   117 NLITLELFDNRLPLVPSQAFEYLSKLRELWLRNNPIETL------------------------PA 157

  Fly   210 SNLWHLHALKSLDMSLNLVEFVRNDSFEGLKELLALSVQGNVMSELDLSAFEGLISLKHLDLSDN 274
            .....:.:|:.||                |.||..||    .:||   :|||||::|:.|:|...
Zfish   158 YAFHRVPSLRRLD----------------LGELRKLS----FISE---AAFEGLLNLRFLNLGMC 199

  Fly   275 NLTMVPTQQLSKLSNLTYLNLGGNRFSQLPAVAFLNLFHLRELHL--SRLDFLQRIDSRAFVDNT 337
            .|..||  .|:.|..|..|.|.||:...:...:|..|..||:|.|  ||:..::|   .||.|..
Zfish   200 GLKDVP--NLTPLVRLEELELSGNQLGVVRPGSFQGLVSLRKLWLMHSRISVIER---NAFDDLK 259

  Fly   338 HLQTLHLNNNPQLSDIPMRLFQGNPNILEVYMQSNSLQTLYSAQFPVDQLQKLYLGDNPLQCNCS 402
            :|:.|:|::| .|..:|..||.                       |:.||::::|..||..|||.
Zfish   260 NLEELNLSHN-SLHSLPHDLFT-----------------------PLQQLERVHLNHNPWVCNCD 300

  Fly   403 LLWL--WRLVTGNFEGVDPGMEHAAGGAVAALAKEADDEELADEATAVAS--TD----DGVAA-- 457
            :|||  |...|...........||..|.......:.|..:....|..:..  ||    :|:||
Zfish   301 VLWLSWWLKETVPDNSTCCARCHAPPGTKGRYIGDLDQRDFTCYAPVIVEPPTDLNVTEGMAAEL 365

  Fly   458 -------------------LAAYIAEQHIVNALH------------TTEPSAYELATSSSNRN-S 490
                               |..:.|.:..::.||            .|.|....:..|:.|.. :
Zfish   366 KCRTGTSMTSVNWLTPNGTLMTHGAYKVRISVLHDGTLNFTNVTMQDTGPYTCMVTNSAGNTTAT 430

  Fly   491 GILRMDRQQIG------CDIWRDKVRTRRK---------------------------------LL 516
            .:|.:.....|      ..:..:.|.|.::                                 |.
Zfish   431 AVLNVSAPDPGNGYSYFTTVTVETVETGQEGHDSPARQFVNETFISFPGPTAASTSAGPTGSMLS 495

  Fly   517 TMSEGEITCPAHIVTVVCA-----------------VITCLLVAMIGISVLYYLRFVKRRRKLLH 564
            ::|......|....||...                 :|.|.:......:|:..:.:..|::..||
Zfish   496 SLSPRATRAPDRPFTVSITDVANLSGLEDVMKTTKIIIGCFVAITFMAAVMLVVFYKLRKQHQLH 560

  Fly   565 E-RGPMRTSKSIINVHDRILQGHNPGGLGLGMSMTLGGGNHVNGLGMTLNYPHHAQTLQAHHHYH 628
            : .||.|..: ||||.|.|      |..| |.|...||.....|.|
Zfish   561 KHHGPARAIE-IINVEDEI------GSAG-GASGITGGSTVHTGAG------------------- 598

  Fly   629 QAMPLQSHGGNGN----HEYQQTTLPQLDKLE-LERYLAAQTIANEYRALKPWELPVKEADDEPE 688
                  :.||:|.    |:.:..|||.:.:.: |..|..|....|....|   .:.....:::|.
Zfish   599 ------TGGGSGQSPRIHDPEIMTLPSVGQADHLNHYYKAHHFNNNVLGL---NMTTGMLNNKPN 654

  Fly   689 HLYERFDHYEYPDTHTMS---KLKQAASLNHSNSSAGPS---PVPPS-------SGKPHVVYVXR 740
                       |.:...:   |:..|..|..:..|..|.   |:|.:       .|..||..| .
Zfish   655 -----------PSSQNQASTLKMGPAGDLGPNPGSISPPLPIPIPMAMTFHGSLKGHSHVPNVQT 708

  Fly   741 -----GRGTGERVSQ 750
                 ..|:.|.|.:
Zfish   709 EPLLLSNGSKESVQE 723

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fili	NP_001369108.1	leucine-rich repeat	75..97	CDD:275378	3/21 (14%)
		leucine-rich repeat	98..121	CDD:275380	5/22 (23%)
		LRR_8	120..180	CDD:404697	24/59 (41%)
		leucine-rich repeat	122..145	CDD:275380	9/22 (41%)
		leucine-rich repeat	146..169	CDD:275380	8/22 (36%)
		LRR	<161..>354	CDD:227223	57/194 (29%)
		leucine-rich repeat	170..193	CDD:275380	8/22 (36%)
		leucine-rich repeat	194..217	CDD:275380	2/22 (9%)
		leucine-rich repeat	218..265	CDD:275380	15/46 (33%)
		leucine-rich repeat	266..289	CDD:275380	8/22 (36%)
		leucine-rich repeat	290..313	CDD:275380	7/22 (32%)
		leucine-rich repeat	314..338	CDD:275380	10/25 (40%)
		LRR_8	337..397	CDD:404697	13/59 (22%)
		leucine-rich repeat	339..360	CDD:275380	8/20 (40%)
lrrc4bb	XP_003201401.1	LRRNT	38..72	CDD:214470	11/35 (31%)
		LRR_8	68..128	CDD:290566	22/82 (27%)
		leucine-rich repeat	70..93	CDD:275380	8/45 (18%)
		LRR_RI	85..293	CDD:238064	82/283 (29%)
		leucine-rich repeat	94..117	CDD:275380	9/22 (41%)
		leucine-rich repeat	118..141	CDD:275380	8/22 (36%)
		LRR_8	140..196	CDD:290566	27/102 (26%)
		leucine-rich repeat	142..165	CDD:275380	10/46 (22%)
		leucine-rich repeat	166..190	CDD:275380	15/46 (33%)
		leucine-rich repeat	191..212	CDD:275380	8/22 (36%)
		LRR_8	212..271	CDD:290566	21/62 (34%)
		leucine-rich repeat	213..236	CDD:275380	7/22 (32%)
		leucine-rich repeat	237..260	CDD:275380	10/25 (40%)
		leucine-rich repeat	261..282	CDD:275380	8/44 (18%)
		TPKR_C2	293..343	CDD:301599	14/49 (29%)
		IG_like	352..435	CDD:214653	14/82 (17%)
		Ig	360..435	CDD:299845	12/74 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910