DRSC/TRiP Functional Genomics Resources

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Protein Alignment Fili and LRRC3C

DIOPT Version :9

Sequence 1:NP_001369108.1 Gene:Fili / 5740472 FlyBaseID:FBgn0085397 Length:789 Species:Drosophila melanogaster
Sequence 2:NP_001182474.1 Gene:LRRC3C / 100505591 HGNCID:40034 Length:275 Species:Homo sapiens


Alignment Length:264 Identity:65/264 - (24%)
Similarity:94/264 - (35%) Gaps:94/264 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly   272 SDNNLTMVPTQQLSKLSNLT-YLNLGGNRFSQLPAVAFLNLFHLRELHLSRLDFLQRIDSRAF-- 333
            |...|:.||    |.:.|.| .|.|..|:.:.:||.||.:|..|.||.||. :.|..:...||  
Human    66 SQAGLSAVP----SGIPNDTRKLYLDANQLASVPAGAFQHLPVLEELDLSH-NALAHLSGAAFQG 125

  Fly   334 VDNTHLQTLHLNNNPQLSDIPMRLFQGNPNILEVYMQSNSLQTLYSAQFPVDQLQKLYLGDNPLQ 398
            ::.| |:.|.|:.| ||:.:|:..|.|      :.:|.|                   |..||..
Human   126 LEGT-LRHLDLSAN-QLASVPVEAFVG------LQIQVN-------------------LSANPWH 163

  Fly   399 CNCSL---LWLWRLVTGNFEGVDPGMEHAAGGAVAALAKE----ADDEELADEATAVASTDDGVA 456
            |:|:|   |...|||.|...|:..|    :|.....:.:|    |.:|||.......|.....||
Human   164 CDCALQEVLRQVRLVPGTGTGIVCG----SGARPDLVGQEFLLLAGEEELCGSGWGGARRSTDVA 224

  Fly   457 AL----------AAYIAEQHIVNALHTTEPSAYELATSSSNRNSGILRMDRQQIGCDIWRDKVRT 511
            .|          .||:...                                      :|:::..|
Human   225 LLVTMGGWLTLMVAYLVHY--------------------------------------VWQNRDET 251

  Fly   512 RRKL 515
            ||.|
Human   252 RRSL 255

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
FiliNP_001369108.1 leucine-rich repeat 75..97 CDD:275378
leucine-rich repeat 98..121 CDD:275380
LRR_8 120..180 CDD:404697
leucine-rich repeat 122..145 CDD:275380
leucine-rich repeat 146..169 CDD:275380
LRR <161..>354 CDD:227223 30/84 (36%)
leucine-rich repeat 170..193 CDD:275380
leucine-rich repeat 194..217 CDD:275380
leucine-rich repeat 218..265 CDD:275380
leucine-rich repeat 266..289 CDD:275380 5/16 (31%)
leucine-rich repeat 290..313 CDD:275380 9/23 (39%)
leucine-rich repeat 314..338 CDD:275380 8/25 (32%)
LRR_8 337..397 CDD:404697 14/59 (24%)
leucine-rich repeat 339..360 CDD:275380 8/20 (40%)
LRRC3CNP_001182474.1 leucine-rich repeat 61..80 CDD:275378 5/17 (29%)
LRR 1 80..101 8/20 (40%)
leucine-rich repeat 81..104 CDD:275378 9/22 (41%)
LRR_8 82..140 CDD:290566 21/60 (35%)
LRR_4 82..120 CDD:289563 14/38 (37%)
LRR 2 104..125 8/21 (38%)
LRR_4 105..144 CDD:289563 15/41 (37%)
leucine-rich repeat 105..129 CDD:275378 8/24 (33%)
LRR 3 129..150 9/22 (41%)
leucine-rich repeat 130..152 CDD:275378 9/28 (32%)
leucine-rich repeat 153..164 CDD:275378 5/29 (17%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24373
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
11.100

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