DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fili and lingo3

DIOPT Version :9

Sequence 1:	NP_001369108.1	Gene:	Fili / 5740472	FlyBaseID:	FBgn0085397	Length:	789	Species:	Drosophila melanogaster
Sequence 2:	XP_004911049.2	Gene:	lingo3 / 100497438	XenbaseID:	XB-GENE-6051175	Length:	605	Species:	Xenopus tropicalis

Alignment Length:	515	Identity:	147/515 - (28%)
Similarity:	234/515 - (45%)	Gaps:	82/515 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 WLCGAIPVLLLLLLTLVILPPETTAFCPSKCQCLGGEANSRA-LCVDAALEDVPIQLNPETKYIN 79
            |.  :|.|.|||||    .|......||::|.|   ..|.|: :|....|..:|..:..||:.::
Frog    10 WF--SIVVFLLLLL----YPEWKVLGCPARCDC---TPNQRSVICHRKRLTTIPEGIPSETRLLD 65

  Fly    80 LTVNRIRTL---EFSLPFYMKLEILDLSQNIIETLGSKNFEYQSELRTLNLSRNLVSSLHKHAFK 141
            |:.||||.|   :|| | |..||.:|||:|||.|:....|.....|:.|.|..|.:..:....|.
Frog    66 LSKNRIRCLNPGDFS-P-YSLLEEVDLSENIISTIEPGAFANLFFLQILKLKGNQLKLIPTGVFT 128

  Fly   142 GLTNLLLLDLSFNRIETVHPTALSDLASLVELDLTNNNIVSLEDNCFKGMNTLEVLVFRNNRLLD 206
            .|:||.|||:|.|:|..:......||.||..|::.:|:::.:....|.|:.:|:.|......|..
Frog   129 KLSNLTLLDISENKIVILLDFMFQDLRSLKSLEVGDNDLLYISQKAFYGLVSLDQLTIEKCNLTS 193

  Fly   207 VPASNLWHLHALKSLDMSLNLVEFVRNDSFEGLKELLALSVQG-NVMSELDLSAFEGLISLKHLD 270
            :...:|.:|..|:.|.:....:..:...:|:.|..|..|.::. .::.::..:||:|| :|..|.
Frog   194 ISPESLSYLQGLEVLRLRYLGINSLEEQNFQKLYNLKELELESWPLLEDVCNTAFQGL-NLTSLS 257

  Fly   271 LSDNNLTMVPTQQLSKLSNLTYLNLGGNRFSQLPAVAFLNLFHLRELHLSRLDFLQRIDSRAFVD 335
            ::..|||.||:..|..:..|.||||..|....:...||.:|..|||||:... ||..::|:||:.
Frog   258 ITYTNLTSVPSAALRNMVYLEYLNLSFNPIRIIQRGAFKDLVRLRELHIVGA-FLSTVESQAFLG 321

  Fly   336 NTHLQTLHLNNNPQLSDIPMRLFQGNPNILEVYMQSNSLQTLYSAQF-PVDQLQKLYLGDNPLQC 399
            ...::.|:::|                         |.|.||..:.| .|:.|:.|.:.||||.|
Frog   322 LRQIRLLNVSN-------------------------NLLATLEESAFQSVNTLETLRVDDNPLAC 361

  Fly   400 NCSLLW-LWRLVTGNFEGVDPGMEHAA---GGAVAALAKEADDEELADEATAVASTDDGVAALAA 460
            :|.||| |.|..|.||:...|.....|   |.|:    ::..|..|.:..|.....
Frog   362 DCRLLWILQRRKTLNFDNHQPVCASPAKIQGNAL----RDFPDSILFEHFTCQKPK--------- 413

  Fly   461 YIAE---QHIVNALHTTEPSAYELATSSSNRNSGILRMDRQQIGCDIWRDKVRTRRKLLT 517
             |.:   |||  ..|..:|.::.            .|.|.:.:...:|   |..:|:::|
Frog   414 -IRDRKLQHI--TAHEGQPVSFH------------CRADGEPVPLIVW---VSPQRRMIT 455

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fili	NP_001369108.1	leucine-rich repeat	75..97	CDD:275378	11/24 (46%)
		leucine-rich repeat	98..121	CDD:275380	10/22 (45%)
		LRR_8	120..180	CDD:404697	20/59 (34%)
		leucine-rich repeat	122..145	CDD:275380	6/22 (27%)
		leucine-rich repeat	146..169	CDD:275380	9/22 (41%)
		LRR	<161..>354	CDD:227223	52/193 (27%)
		leucine-rich repeat	170..193	CDD:275380	5/22 (23%)
		leucine-rich repeat	194..217	CDD:275380	5/22 (23%)
		leucine-rich repeat	218..265	CDD:275380	10/47 (21%)
		leucine-rich repeat	266..289	CDD:275380	8/22 (36%)
		leucine-rich repeat	290..313	CDD:275380	9/22 (41%)
		leucine-rich repeat	314..338	CDD:275380	10/23 (43%)
		LRR_8	337..397	CDD:404697	12/60 (20%)
		leucine-rich repeat	339..360	CDD:275380	2/20 (10%)
lingo3	XP_004911049.2	LRR	41..359	CDD:227223	102/346 (29%)
		leucine-rich repeat	61..84	CDD:275380	11/24 (46%)
		leucine-rich repeat	85..108	CDD:275380	10/22 (45%)
		leucine-rich repeat	109..132	CDD:275380	6/22 (27%)
		leucine-rich repeat	133..156	CDD:275380	9/22 (41%)
		leucine-rich repeat	157..180	CDD:275380	5/22 (23%)
		leucine-rich repeat	181..204	CDD:275380	5/22 (23%)
		leucine-rich repeat	205..228	CDD:275380	4/22 (18%)
		leucine-rich repeat	229..252	CDD:275380	6/23 (26%)
		leucine-rich repeat	253..276	CDD:275380	8/22 (36%)
		leucine-rich repeat	277..298	CDD:275380	8/20 (40%)
		leucine-rich repeat	301..324	CDD:275380	10/23 (43%)
		leucine-rich repeat	325..345	CDD:275380	7/44 (16%)
		PCC	329..>399	CDD:188093	27/98 (28%)
		Ig	413..502	CDD:416386	12/70 (17%)
		Ig strand A'	419..423	CDD:409353	3/5 (60%)
		Ig strand B	429..438	CDD:409353	2/20 (10%)
		Ig strand C	443..448	CDD:409353	1/7 (14%)
		Ig strand C'	451..453	CDD:409353	1/1 (100%)
		Ig strand D	462..465	CDD:409353
		Ig strand E	468..475	CDD:409353
		Ig strand F	481..489	CDD:409353
		Ig strand G	492..502	CDD:409353
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm14097
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910