DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fili and nyx

DIOPT Version :9

Sequence 1:	NP_001369108.1	Gene:	Fili / 5740472	FlyBaseID:	FBgn0085397	Length:	789	Species:	Drosophila melanogaster
Sequence 2:	XP_031752664.1	Gene:	nyx / 100495354	XenbaseID:	XB-GENE-949924	Length:	468	Species:	Xenopus tropicalis

Alignment Length:	374	Identity:	110/374 - (29%)
Similarity:	169/374 - (45%)	Gaps:	63/374 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 CPSKCQCLGGEANSRALCVDAALEDVPIQLNPETKYINLTVNRIRTLEFSLPFYMKLEILDLSQN 106
            |||.|.|. .|.:...||....|.::|.:...|..:|||..|.|:.|.
Frog    29 CPSNCVCT-QERSCSVLCDRIGLPEIPKEFPCEASFINLDKNNIKFLY----------------- 75

  Fly   107 IIETLGSKNFEYQSELRTLNLSRNLVSSLHKHAFKGLTNLLLLDLSFNR-IETVHPTALSDLASL 170
                  .:.|.....|:.|:||.|.:|.:...|||||.||..|.::.|. |..:|....|.|..|
Frog    76 ------ERAFGTLPLLKGLSLSHNNISFITPGAFKGLPNLTELKMAHNEYIRYLHTRTFSVLKKL 134

  Fly   171 VELDLTNNNIVSLEDNCFKGMNTLEVLVFRNNRLLDVPAS-----NLWHLHALKSLDMSLNLVEF 230
            |:|||.:.|:.::.|..|..:.:|..|:|..|....:|.:     ||.|::      :..|.:|.
Frog   135 VKLDLADCNLFNIPDRIFVELPSLHELIFFQNNFRRIPGAIRGMENLTHIY------LESNRIEA 193

  Fly   231 VRNDSFEGLKELLALSVQGNVMSELDLSAFEGLISLKHLDLSDNNLTMVPTQQLSKLSNLTYLNL 295
            |..:|.:.|..|..|::|.|.::.:...:|:....|::|.|:||.|..:|......|..|..|||
Frog   194 VAYNSLQDLINLKYLNLQDNKINVIHDRSFQDCQKLEYLYLNDNLLNELPENSFKGLKCLKMLNL 258

  Fly   296 GGNRFSQLPAVAFLNLFHLRELHLSRLDFLQRIDSRAFVDNTHLQTLHLNNNPQLSDIPMRLFQG 360
            |||....:.:..|.:|..|..|:|.| :.:..|:..||.:.|.|.|||||:| .|:.:|..:|:
Frog   259 GGNFIRNVSSAWFQDLVELEVLYLDR-NRISYIEEGAFENLTSLVTLHLNSN-NLTTLPFEVFR- 320

  Fly   361 NPNILEVYMQSNSLQTLYSAQFPVDQLQKLYLGDNPLQCNCSLLWL--W 407
                                  ||..|.:|:|..||.:|:|.:.||  |
Frog   321 ----------------------PVYFLGRLFLFRNPWECDCRIKWLQDW 347

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fili	NP_001369108.1	leucine-rich repeat	75..97	CDD:275378	6/21 (29%)
		leucine-rich repeat	98..121	CDD:275380	1/22 (5%)
		LRR_8	120..180	CDD:404697	24/60 (40%)
		leucine-rich repeat	122..145	CDD:275380	11/22 (50%)
		leucine-rich repeat	146..169	CDD:275380	7/23 (30%)
		LRR	<161..>354	CDD:227223	61/197 (31%)
		leucine-rich repeat	170..193	CDD:275380	8/22 (36%)
		leucine-rich repeat	194..217	CDD:275380	8/27 (30%)
		leucine-rich repeat	218..265	CDD:275380	10/46 (22%)
		leucine-rich repeat	266..289	CDD:275380	8/22 (36%)
		leucine-rich repeat	290..313	CDD:275380	9/22 (41%)
		leucine-rich repeat	314..338	CDD:275380	7/23 (30%)
		LRR_8	337..397	CDD:404697	17/59 (29%)
		leucine-rich repeat	339..360	CDD:275380	10/20 (50%)
nyx	XP_031752664.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24373
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010