DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fili and lrfn5

DIOPT Version :9

Sequence 1:	NP_001369108.1	Gene:	Fili / 5740472	FlyBaseID:	FBgn0085397	Length:	789	Species:	Drosophila melanogaster
Sequence 2:	XP_002941802.2	Gene:	lrfn5 / 100495182	XenbaseID:	XB-GENE-923445	Length:	775	Species:	Xenopus tropicalis

Alignment Length:	578	Identity:	133/578 - (23%)
Similarity:	193/578 - (33%)	Gaps:	191/578 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 CPSKCQCLGGEANSRALCVDAALEDVPIQLNPETKYINLTVNRIRTLEFSLPFYMKLEILDLSQN 106
            ||.:|.|.....|...||....|..||..:|.            :|:|           |.|:.|
Frog    20 CPKRCACQNLSPNLATLCDKKGLLFVPPNINR------------KTVE-----------LRLADN 61

  Fly   107 IIETLGSKNFEYQSELRTLNLSRNLVSSLHKHAFKGLTNLLLLDLSFNRIETVHPTALSDLASLV 171
            .:.::..|:|...:.|..|.||||.:|.:..|||..|.||..|.|:.||:..
Frog    62 FVTSIKRKDFANMTSLVDLTLSRNTISYITPHAFSDLRNLRALHLNSNRLTR------------- 113

  Fly   172 ELDLTNNNIVSLEDNCFKGMNTLEVLVFRNNRLLDVPASNLWHLHALKSLDMSLNLVEFVRNDSF 236
                                                                       |.||.|
Frog   114 -----------------------------------------------------------VANDMF 119

  Fly   237 EGLKELLALSVQGNVMSELDLSAFEGLISLKHLDLSDNNLTMVPTQQLSKLSNLTYLNLGGNRFS 301
            .||..|..|.:..|.::.:..:||:.:::|:.||||.|||..:|...:.|:.:|..|:|..|...
Frog   120 SGLLNLHHLILNNNQLTLISSTAFDDVLALEELDLSYNNLETIPWDAVEKMVSLHTLSLDHNMIE 184

  Fly   302 QLPAVAFLNLFHLRELHLSRLDFLQRIDSRAFVDNTHLQTLHLNNNPQLSDIPMRLFQGNPNILE 366
            .:|...|   .||.:  |:|||          |.:..||.|.          |..|||
Frog   185 HIPKGTF---SHLHK--LNRLD----------VTSNKLQKLP----------PDPLFQ------- 217

  Fly   367 VYMQSNSLQTLYSAQFPVDQLQKLYLGDNPLQCNCSLLWLWRLVTGNFEGVDPGMEHAAGGAVAA 431
                  ..|.|.::.........|..|.|||.|||.||||.||:.      :..:|..|...:.:
Frog   218 ------RAQVLVTSGIISSSTFALSFGGNPLHCNCELLWLRRLLR------EDDLETCASPPLLS 270

  Fly   432 --LAKEADDEELADEATAVASTDDGVAALAAYIAEQHIVNALHTTEPSAYELATSSSNRNSG--I 492
              ......:||...|...:......:..|....|... ..||...||:.:.::..|...::|  |
Frog   271 GRYFWSITEEEFLCEPPLITRYTQELRVLEGQRATLR-CKALGDPEPAIHWISPESKLISNGTRI 334

  Fly   493 LRMDRQQIGCDIWRDKVRTRRKLLTMSEGEITC----PAHIVTVVCAVITCLLVAMIGISVLYYL 553
            |..|...:  ||....|:        ..|..:|    ||...|..              |||:.:
Frog   335 LVYDNGTL--DILITTVK--------DTGSFSCIASNPAGETTKT--------------SVLHII 375

  Fly   554 RFVKRRRKLLHERGPMRTSKSIINVHDRILQGHNPGGLGLGMSMTLGGGNHVNGLGMT 611
                   ||.|          ::|..:.| |..:||...:..| |..|.|..:..|.|
Frog   376 -------KLPH----------LVNSTNHI-QEPDPGSSDISTS-TKSGSNASSSNGDT 414

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fili	NP_001369108.1	leucine-rich repeat	75..97	CDD:275378	2/21 (10%)
		leucine-rich repeat	98..121	CDD:275380	5/22 (23%)
		LRR_8	120..180	CDD:404697	17/59 (29%)
		leucine-rich repeat	122..145	CDD:275380	11/22 (50%)
		leucine-rich repeat	146..169	CDD:275380	5/22 (23%)
		LRR	<161..>354	CDD:227223	37/192 (19%)
		leucine-rich repeat	170..193	CDD:275380	0/22 (0%)
		leucine-rich repeat	194..217	CDD:275380	0/22 (0%)
		leucine-rich repeat	218..265	CDD:275380	11/46 (24%)
		leucine-rich repeat	266..289	CDD:275380	10/22 (45%)
		leucine-rich repeat	290..313	CDD:275380	6/22 (27%)
		leucine-rich repeat	314..338	CDD:275380	6/23 (26%)
		LRR_8	337..397	CDD:404697	12/59 (20%)
		leucine-rich repeat	339..360	CDD:275380	6/20 (30%)
lrfn5	XP_002941802.2	leucine-rich repeat	53..76	CDD:275380	7/33 (21%)
		LRR_8	55..111	CDD:404697	22/66 (33%)
		leucine-rich repeat	77..100	CDD:275380	11/22 (50%)
		leucine-rich repeat	101..124	CDD:275380	11/94 (12%)
		leucine-rich repeat	125..148	CDD:275380	5/22 (23%)
		LRR_8	149..207	CDD:404697	23/72 (32%)
		leucine-rich repeat	149..172	CDD:275380	10/22 (45%)
		leucine-rich repeat	173..196	CDD:275380	8/25 (32%)
		leucine-rich repeat	197..215	CDD:275380	9/37 (24%)
		leucine-rich repeat	222..244	CDD:275378	6/21 (29%)
		Ig	287..374	CDD:416386	22/111 (20%)
		Ig strand A	287..290	CDD:409353	0/2 (0%)
		Ig strand A'	294..297	CDD:409353	0/2 (0%)
		Ig strand B	303..311	CDD:409353	1/8 (13%)
		Ig strand C	317..322	CDD:409353	0/4 (0%)
		Ig strand C'	325..327	CDD:409353	1/1 (100%)
		Ig strand D	333..337	CDD:409353	2/3 (67%)
		Ig strand E	340..344	CDD:409353	0/5 (0%)
		Ig strand F	354..361	CDD:409353	1/6 (17%)
		Ig strand G	364..374	CDD:409353	4/23 (17%)
		FN3	422..495	CDD:419708
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910