DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fili and lrrtm1

DIOPT Version :9

Sequence 1:	NP_001369108.1	Gene:	Fili / 5740472	FlyBaseID:	FBgn0085397	Length:	789	Species:	Drosophila melanogaster
Sequence 2:	XP_002935525.1	Gene:	lrrtm1 / 100493874	XenbaseID:	XB-GENE-966481	Length:	521	Species:	Xenopus tropicalis

Alignment Length:	624	Identity:	140/624 - (22%)
Similarity:	232/624 - (37%)	Gaps:	157/624 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 WLCGAIPVLLLLLL-TLVILPPETTAFCPSKCQCLGGEANSRAL-CVDAALEDVPIQLNPETKYI 78
            ||....|.|:|..| ..|.:.|...:.||..|:|.|     |.| |....:.::|..|:
Frog    12 WLLRKPPGLILCTLGVFVKMLPLVNSGCPRLCRCEG-----RFLYCESQNVTEIPHNLS------ 65

  Fly    79 NLTVNRIRTLEFSLPFYMKLEILDLSQNIIETLGSKNFEYQSELRTLNLSRNLVSSLHKHAFKGL 143
                              .:..|.|..|.:..|....|....:|..|.|..|.:.::..:||..|
Frog    66 ------------------GVMGLSLRYNSLSELQDGQFTGLIQLTWLYLDHNHIHTVEGNAFHKL 112

  Fly   144 TNLLLLDLSFNRIETVHPTALSDLASLVELDLTNNNIVSLEDNCFKGMNTLEVLVFRNNRLLDVP 208
            ..:..|.||.|:|..:..|....:.:|..:||:|||:.|||.:.|.|:..|..|..|.|.:..||
Frog   113 RRVKELTLSSNKITHLANTTFRPMPNLRSVDLSNNNLQSLEADLFHGLRKLTTLHMRYNAIKFVP 177

  Fly   209 ASNLWHLHALKSLDMSLNLVEFVRNDSFEGLKELLALSVQGNVMSELDLSAFEGLISLKHLDLSD 273
            ........:||.||:..|.::.:..:||.||.:|..|.::.|.:.:::|:.|..|:||..|.:..
Frog   178 VRIFQDCRSLKFLDLGYNQLKSLARNSFAGLFKLTELHLEHNDLVKVNLAHFPRLLSLHSLFMRR 242

  Fly   274 NNLTMVPTQQLSKLSNLTYLNLGGNRFSQLPAVAFLNLFHLRELHLSRLDFLQRIDSRAFVDNTH 338
            |.:|:| ...|..:..|..::|.||.                         ::.|:...|....|
Frog   243 NKVTIV-VNSLDFVWKLEKMDLSGNE-------------------------IEYIEPHVFESLPH 281

  Fly   339 LQTLHLNNNPQLSDIPMRLFQGNPNILEVYMQSNSLQTLYSAQFPVDQLQKLYLGDNPLQCN--- 400
            |::|.|::|        ||...:|.||      ||.::|.|          :.|..|...|.
Frog   282 LESLQLDSN--------RLTYVDPRIL------NSWKSLSS----------ITLAGNNWDCGRNV 322

  Fly   401 CSLL-WLWRLVTGNFEGVDPGMEHAAGGAVAALAKEADDEELADEATAVASTDDGVAALAAYIAE 464
            |:|. ||     ..|:|      ...|..:....:.|..|::.|........||.|...:|....
Frog   323 CALASWL-----SAFKG------RCDGNMLCTTPEYAQGEDVLDAVYFFRLCDDPVDPTSANAIS 376

  Fly   465 QHIVN----ALHTTEPSAYELATSSSNRNSGILRMDRQQIGCDIWRDKVRTRRKLLTMSEGEITC 525
            ..:.|    |:.:...::|.:..:...|.:.:                   :...:.....|.|.
Frog   377 TALNNSDRIAIDSPTATSYNVQDTEGERTTNV-------------------QTATVANEHHENTV 422

  Fly   526 PAH-IVTVVCAVITCLLVAMIGISV--------LYYLR--FVKRRRK-----LLHERGPMRTSKS 574
            ..| :||...|:|...|:.::.:.|        |..||  ||.:|||     .:|:...|...:.
Frog   423 QIHKVVTGTMALIFSFLIVVLMLYVSWKCFPASLRQLRQCFVTQRRKQKQKQTMHQMASMSAQEY 487

  Fly   575 IINVHDRILQGHNPGGLGLGMSMTLGGGNHVNGLGMTLN 613
            .::        :.|              ||:.|..:.:|
Frog   488 YVD--------YKP--------------NHIEGALVIIN 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fili	NP_001369108.1	leucine-rich repeat	75..97	CDD:275378	0/21 (0%)
		leucine-rich repeat	98..121	CDD:275380	5/22 (23%)
		LRR_8	120..180	CDD:404697	18/59 (31%)
		leucine-rich repeat	122..145	CDD:275380	7/22 (32%)
		leucine-rich repeat	146..169	CDD:275380	6/22 (27%)
		LRR	<161..>354	CDD:227223	51/192 (27%)
		leucine-rich repeat	170..193	CDD:275380	11/22 (50%)
		leucine-rich repeat	194..217	CDD:275380	6/22 (27%)
		leucine-rich repeat	218..265	CDD:275380	15/46 (33%)
		leucine-rich repeat	266..289	CDD:275380	6/22 (27%)
		leucine-rich repeat	290..313	CDD:275380	4/22 (18%)
		leucine-rich repeat	314..338	CDD:275380	2/23 (9%)
		LRR_8	337..397	CDD:404697	16/59 (27%)
		leucine-rich repeat	339..360	CDD:275380	6/20 (30%)
lrrtm1	XP_002935525.1	LRRNT	38..>61	CDD:214470	8/27 (30%)
		LRR	53..>316	CDD:227223	81/336 (24%)
		leucine-rich repeat	70..90	CDD:275380	5/19 (26%)
		leucine-rich repeat	91..114	CDD:275380	7/22 (32%)
		LRR_8	114..173	CDD:338972	21/58 (36%)
		leucine-rich repeat	115..138	CDD:275380	6/22 (27%)
		leucine-rich repeat	139..162	CDD:275380	11/22 (50%)
		leucine-rich repeat	163..186	CDD:275380	6/22 (27%)
		leucine-rich repeat	187..210	CDD:275380	9/22 (41%)
		leucine-rich repeat	211..234	CDD:275380	6/22 (27%)
		leucine-rich repeat	235..257	CDD:275380	6/22 (27%)
		leucine-rich repeat	258..281	CDD:275380	6/47 (13%)
		leucine-rich repeat	282..300	CDD:275380	7/25 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR24373
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.010