Protein Alignment Fili and lrrc4

DIOPT Version :9

• Sequence 1: NP_001369108.1
• Gene: Fili / 5740472
• FlyBaseID: FBgn0085397
• Length: 789
• Species: Drosophila melanogaster
• Sequence 2: XP_002939414.1
• Gene: lrrc4 / 100493671
• XenbaseID: XB-GENE-968937
• Length: 641
• Species: Xenopus tropicalis
• Alignment Length: 665
• Identity: 146/665 - (21%)
• Similarity: 253/665 - (38%)
• Gaps: 152/665 - (22%)

  Fly    42 CPSKCQCLGGEANSRALCVDAALEDVPIQLNPETKYINLTVNRIRTLEFSLPFYM-KLEILDLSQ 105
            |||.|.|  ....|:.:|....|.:||..:...|:.:||..|.|:.::.....:: .||:|.|.:
 Frog    40 CPSVCSC--SNQFSKVVCTRRGLSEVPQGIPSNTRSLNLMENNIQMIQADTFRHLHHLEVLQLGR 102

  Fly   106 NIIETLGSKNFEYQSELRTLNLSRNLVSSLHKHAFKGLTNLLLLDLSFNRIETVHPTALSDLASL 170
            |.|..:....|...:.|.||.|..|.::.:...||:.|:.|..|.|..|.||::...|.:.:.||
 Frog   103 NSIRQIEVGAFNGLASLNTLELFDNWLTVIPSGAFEYLSKLRELWLRNNPIESIPSYAFNRVPSL 167

  Fly   171 VELDLTN-NNIVSLEDNCFKGMNTLEVLVFRNNRLLDVPASNLWHLHALKSLDMSLNLVEFVRND 234
            :.|||.. ..:..:.:..|:|:..|:.|......:.|:|  ||..|..|:.|::|.|....::..
 Frog   168 MRLDLGELKKLEYISEGAFEGLYNLKYLNLGMCNIRDMP--NLTPLVGLEELEISGNNFPEIKPG 230

  Fly   235 SFEGLKELLALSVQGNVMSELDLSAFEGLISLKHLDLSDNNLTMVPTQQLSKLSNLTYLNLGGNR 299
            ||.||:.|..|.:..:.::.::.:||:.|.||..|:|:.||:|.:|....:.|..|..|:|..|.
 Frog   231 SFHGLRSLKKLWIMNSQINTIERNAFDDLTSLVELNLAHNNVTSLPHDLFAPLKYLVELHLHHNP 295

  Fly   300 FSQLPAVAFLNLF-------------------HLRELHLSRLDFLQRIDSRAFV----------- 334
            :.....|.:|:.:                   |:|..::..:|......|..|:
 Frog   296 WDCDCDVLWLSWWLREYIPTNSTCCGRCHSPPHMRGKYVVEVDHSMFQCSAPFIMDAPRDLNISE 360

  Fly   335 ---------------------DNTHLQTLHLNNNPQLSDIPMRLFQGNPNILEVYMQSNSLQTLY 378
                                 :.|.|  .|.:|:|:::    .|..|..|..:|.:....:.|..
 Frog   361 GRMAELKCRTSAMSSVRWLLPNGTVL--THASNHPRIT----ILNDGTLNFSQVLLTDTGVYTCM 419

  Fly   379 SAQFPVDQLQKLYLGDNPLQCNCSLLWLWRLVTGNFEGVDPGMEHAAGGAVAALAKEADDEELAD 443
            ......:.....||..:..:.|.|....:..||.....|.|                   |:::.
 Frog   420 VTNVAGNSNASAYLNVSTAELNTSNYSFFTTVTVETTEVAP-------------------EDISM 465

  Fly   444 EATAVASTDDGVAALAAYIAEQHIVNALHTTE-PSAYELATSSSNRNSGILRMDRQQIGCDIWRD 507
            ....|.:|..|..  .||.....::  :.||: |....:.||.:.                   |
 Frog   466 IFKPVPTTSTGYQ--PAYTTTTTVL--IQTTKMPKQVAVPTSDAG-------------------D 507

  Fly   508 KVRTRRKLLTMSEGEITCPAHIVTVVCAVITCLLVAMIGISVLYYLRFVKRRRKLLHERGPMRTS 572
            |::|       |..|:.....|:......:|.|..||:   :::|     :.||...:|..:..:
 Frog   508 KMQT-------SLDEVMKTTKIIIGCFVAVTLLAAAML---IVFY-----KLRKRHQQRSTVAAA 557

  Fly   573 KS--IINVHDRILQGHNPGGLGLGMSMTLGGGNHVNGLGMTLNYPHHAQTLQAHHHYHQAMPLQS 635
            ::  ||.|.:.|..| :|.|              |:|.|..:     ..|:..|.:|:...|..
 Frog   558 RTVEIIQVDEDIPSG-SPTG--------------VSGEGAVV-----LPTIHDHMNYNTYKPAH- 601

  Fly   636 HG--------GNGNH 642
            ||        ||..|
 Frog   602 HGAHWTANSIGNSLH 616

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Fili	NP_001369108.1	leucine-rich repeat	75..97	CDD:275378	5/22 (23%)
		leucine-rich repeat	98..121	CDD:275380	7/22 (32%)
		LRR_8	120..180	CDD:404697	20/60 (33%)
		leucine-rich repeat	122..145	CDD:275380	8/22 (36%)
		leucine-rich repeat	146..169	CDD:275380	7/22 (32%)
		LRR	<161..>354	CDD:227223	53/244 (22%)
		leucine-rich repeat	170..193	CDD:275380	6/23 (26%)
		leucine-rich repeat	194..217	CDD:275380	7/22 (32%)
		leucine-rich repeat	218..265	CDD:275380	13/46 (28%)
		leucine-rich repeat	266..289	CDD:275380	8/22 (36%)
		leucine-rich repeat	290..313	CDD:275380	6/41 (15%)
		leucine-rich repeat	314..338	CDD:275380	4/55 (7%)
		LRR_8	337..397	CDD:404697	12/59 (20%)
		leucine-rich repeat	339..360	CDD:275380	5/20 (25%)
lrrc4	XP_002939414.1	LRRNT	40..71	CDD:214470	10/32 (31%)
		LRR	<68..285	CDD:227223	63/218 (29%)
		leucine-rich repeat	71..94	CDD:275380	5/22 (23%)
		leucine-rich repeat	95..118	CDD:275380	7/22 (32%)
		leucine-rich repeat	119..142	CDD:275380	8/22 (36%)
		leucine-rich repeat	143..166	CDD:275380	7/22 (32%)
		leucine-rich repeat	167..191	CDD:275380	6/23 (26%)
		leucine-rich repeat	192..213	CDD:275380	7/22 (32%)
		leucine-rich repeat	214..237	CDD:275380	8/22 (36%)
		leucine-rich repeat	238..261	CDD:275380	5/22 (23%)
		leucine-rich repeat	262..283	CDD:275380	7/20 (35%)
		LRRCT	294..345	CDD:214507	6/50 (12%)
		IG_like	353..435	CDD:214653	12/87 (14%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm9420
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910