DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fili and lingo2

DIOPT Version :9

Sequence 1:	NP_001369108.1	Gene:	Fili / 5740472	FlyBaseID:	FBgn0085397	Length:	789	Species:	Drosophila melanogaster
Sequence 2:	XP_004910881.1	Gene:	lingo2 / 100490134	XenbaseID:	XB-GENE-922286	Length:	612	Species:	Xenopus tropicalis

Alignment Length:	406	Identity:	131/406 - (32%)
Similarity:	191/406 - (47%)	Gaps:	36/406 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 AIPVLLLLLLTLVILPPETTAF-CPSKCQCLGGEANSRALCVDAALEDVPIQLNPETKYINLTVN 83
            |.|...:|.|..::|....:|| ||:||:|  ...|....|....|..:|..:..|||.::|:.|
Frog     9 ATPCWHILCLVAMLLVFMGSAFGCPAKCEC--SAQNKSVSCHRRRLVTIPEGIPIETKILDLSKN 71

  Fly    84 RIRTLE-FSLPFYMKLEILDLSQNIIETLGSKNFEYQSELRTLNLSRNLVSSLHKHAFKGLTNLL 147
            :::::. .....|..||.:|||.|||..:....|.....||:|:|..|.:..:....|.||:||.
Frog    72 KLKSVNPVDFVSYPLLEDIDLSDNIISNVEPGAFNSLFNLRSLSLKGNRLKLVPLGVFTGLSNLT 136

  Fly   148 LLDLSFNRIETVHPTALSDLASLVELDLTNNNIVSLEDNCFKGMNTLEVLVFRNNRLLDVPASNL 212
            .||:|.|:|..:......||.||..|::.:|.:|.:....|.|:.:||.|......|..||...|
Frog   137 KLDISENKIVILLDYMFQDLHSLKSLEVGDNELVYISHRAFSGLVSLEQLTLEKCNLTAVPTDAL 201

  Fly   213 WHLHALKSLDMS-LNLVEFVRNDSFEGLKELLALSVQGNVMSELDLSAFEGLISLKHLDLSD-NN 275
            .|||.|.||.:. ||:                      ||:...   ||:.|..||.|::|. ..
Frog   202 SHLHNLYSLHLKYLNI----------------------NVLPPF---AFKRLFHLKILEISYWPL 241

  Fly   276 LTMVPTQQLSKLSNLTYLNLGGNRFSQLPAVAFLNLFHLRELHLSRLDFLQRIDSRAFVDNTHLQ 340
            |.:||...|..| |||:|::.....|.:|..|..:|.:|..|:|| .:.:..||:..|.|...||
Frog   242 LDLVPANSLYGL-NLTFLSITNTNLSTIPYHALKHLIYLTHLNLS-YNPIGIIDTGVFSDLVRLQ 304

  Fly   341 TLHLNNNPQLSDIPMRLFQGNPNILEVYMQSNSLQTLYSAQFPVDQ-LQKLYLGDNPLQCNCSLL 404
            .||| ...||..|....|||...:..:.:..|.|:||....|...: |:.|.:.||||.|:|.|:
Frog   305 ELHL-VGAQLRTIEPHAFQGLRFLRLLNVSQNLLETLEENAFQSPKALEVLCIDDNPLVCDCRLI 368

  Fly   405 W-LWRLVTGNFEGVDP 419
            | |.|....:|.|..|
Frog   369 WMLQRHPMLHFGGQQP 384

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fili	NP_001369108.1	leucine-rich repeat	75..97	CDD:275378	5/22 (23%)
		leucine-rich repeat	98..121	CDD:275380	9/22 (41%)
		LRR_8	120..180	CDD:404697	21/59 (36%)
		leucine-rich repeat	122..145	CDD:275380	8/22 (36%)
		leucine-rich repeat	146..169	CDD:275380	8/22 (36%)
		LRR	<161..>354	CDD:227223	61/194 (31%)
		leucine-rich repeat	170..193	CDD:275380	6/22 (27%)
		leucine-rich repeat	194..217	CDD:275380	9/22 (41%)
		leucine-rich repeat	218..265	CDD:275380	10/47 (21%)
		leucine-rich repeat	266..289	CDD:275380	9/23 (39%)
		leucine-rich repeat	290..313	CDD:275380	7/22 (32%)
		leucine-rich repeat	314..338	CDD:275380	8/23 (35%)
		LRR_8	337..397	CDD:404697	20/60 (33%)
		leucine-rich repeat	339..360	CDD:275380	9/20 (45%)
lingo2	XP_004910881.1	LRRNT	31..64	CDD:214470	10/34 (29%)
		leucine-rich repeat	43..61	CDD:275380	3/17 (18%)
		leucine-rich repeat	63..86	CDD:275380	5/22 (23%)
		internalin_A	<66..>285	CDD:380193	75/244 (31%)
		leucine-rich repeat	87..110	CDD:275380	9/22 (41%)
		leucine-rich repeat	111..134	CDD:275380	8/22 (36%)
		leucine-rich repeat	135..158	CDD:275380	8/22 (36%)
		leucine-rich repeat	159..182	CDD:275380	6/22 (27%)
		leucine-rich repeat	183..206	CDD:275380	9/22 (41%)
		leucine-rich repeat	207..254	CDD:275380	19/72 (26%)
		leucine-rich repeat	255..278	CDD:275380	7/22 (32%)
		LRR_8	279..337	CDD:338972	20/59 (34%)
		leucine-rich repeat	279..302	CDD:275380	8/23 (35%)
		leucine-rich repeat	303..326	CDD:275380	11/23 (48%)
		leucine-rich repeat	327..347	CDD:275380	5/19 (26%)
		TPKR_C2	359..402	CDD:387596	12/26 (46%)
		Ig	429..504	CDD:386229
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm9420
Panther	1	1.100	-	-	O	PTHR24373
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.100