Protein Alignment Fili and tlr3

DIOPT Version :10

• Sequence 1: NP_001369108.1
• Gene: Fili / 5740472
• FlyBaseID: FBgn0085397
• Length: 789
• Species: Drosophila melanogaster
• Sequence 2: XP_002934448.3
• Gene: tlr3 / 100486223
• XenbaseID: XB-GENE-491049
• Length: 897
• Species: Xenopus tropicalis
• Alignment Length: 609
• Identity: 131/609 - (21%)
• Similarity: 230/609 - (37%)
• Gaps: 165/609 - (27%)

  Fly    59 CVDAALEDVPIQLNPETKYINLTVNRIRTL-EFSLPFYMKLEILD-------------------- 102
            |....|..:|..|....|.::|:.|:::.| ..:|..|.:||.||
 Frog    35 CSHLKLSAIPSDLPRNIKALDLSHNQLKKLPAANLSVYDQLERLDAGFNTLHQFEPALCKQLLML 99

  Fly   103 ----LSQNIIETLGSKNFEYQSELRTLNLSRNLVSSLHKHAFKGLTNLLLLDLSF---------- 153
                |..|....:...:|.:...|..|:|:.|.:|::..:.|:.|.|||.||:|.
 Frog   100 KTLNLEHNEFTKISENDFTFCVHLSELHLASNGISNIDGNPFEKLENLLFLDMSHNKMISTALGN 164

  Fly   154 --------------NRIETVHPTALSDLA--SLVELDLTNNNIVSLEDNCFKGMNTLEVLVFRNN 202
                          |:|..::..|...||  ||.:|||::|.:..:...||:.:.:...||.:|.
 Frog   165 KQQLNNLKELYLNSNKISKLNKEAFEFLANTSLQKLDLSSNPLTEINPGCFQAIGSFAALVIQNT 229

  Fly   203 RL----LDVPASNLWHLHALKSLDMSLNLVEFVRNDSFEGLKE--LLALSVQGNVMSELDLSAFE 261
            :|    .:...|.|.|. .:::|.::...:..:||.:|:||.:  |..|.:.||.:|::|..:|.
 Frog   230 QLDPQRTEQVCSELAHT-GVRNLTLNNIRLSKIRNTTFKGLADTNLTVLDLSGNSLSQIDNDSFV 293

  Fly   262 GLISLKHLDLSDNNLTMVPTQQLSKLS--------------------------NLTYLNLGGNRF 300
            .|.:|:.|:|.:|:::.|..:..:.||                          |:.|||:..|:.
 Frog   294 SLGALEILNLENNDISHVNPKTFNGLSKVRVLNLRKSLSSNLKLDDLSFQSLHNVQYLNMEANKI 358

  Fly   301 SQLPAVAFLNLFHLRELHLS-----------------------RLDF----LQRIDSRAFVDNTH 338
            ..:....|:.|..|..|.||                       .|:.    |.:|::.||:...|
 Frog   359 ISITEHTFIGLTSLTNLSLSDSTLQQHTLTNRTFLSLSKSPLYHLNLTKTGLTKIENGAFLCLKH 423

  Fly   339 LQTLHLNNNPQLSDIPMRLFQGNPNILEVYMQSNSLQTLYSAQFP-VDQLQKLYLGDNPLQCNCS 402
            ||.|.:..|....::.....:|..||..:|:..|...||.|..|. ...|.||||....|
 Frog   424 LQLLDMGLNQIDQEVSGNELEGLANIEMIYLSYNRRITLTSNSFIFAPSLSKLYLRKTAL----- 483

  Fly   403 LLWLWRLVTGNFEGVDPGMEHAAGGAVAALAKEADDEELADEATAVASTDDGVAALAAYIAEQHI 467
                      .|..::|                 ...::....|.:..:::.:|.:     ::.:
 Frog   484 ----------TFRDLNP-----------------SPFKVLQNLTVLDLSNNNIANI-----QEDV 516

  Fly   468 VNALHTTEPSAYE---LATSSSNRNSGILRMDRQQIGCDIWRDKVRTRRKLLTMSEGEITCPAHI 529
            ..:|......::|   ||......|.|         |..::...::...||..:|.|....||:.
 Frog   517 FESLSNLRILSFEHNNLARLWKEANPG---------GPVLFLKGLKNLEKLSLLSNGFDEIPANA 572

  Fly   530 VTVVCAVITCLLVAMIGISVLYYL 553
            ...:|.    |.|..||.:.:|.|
 Frog   573 FKGLCK----LKVLDIGENNVYIL 592

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Fili	NP_001369108.1	LRR	71..>348	CDD:443914	88/386 (23%)
		leucine-rich repeat	75..97	CDD:275378	6/22 (27%)
		leucine-rich repeat	98..121	CDD:275380	7/46 (15%)
		leucine-rich repeat	122..145	CDD:275380	7/22 (32%)
		leucine-rich repeat	146..169	CDD:275380	10/48 (21%)
		leucine-rich repeat	170..193	CDD:275380	7/22 (32%)
		leucine-rich repeat	194..217	CDD:275380	7/26 (27%)
		leucine-rich repeat	218..265	CDD:275380	14/48 (29%)
		leucine-rich repeat	266..289	CDD:275380	7/48 (15%)
		leucine-rich repeat	290..313	CDD:275380	6/22 (27%)
		leucine-rich repeat	314..338	CDD:275380	9/50 (18%)
		LRR_8	337..397	CDD:404697	19/60 (32%)
		leucine-rich repeat	339..360	CDD:275380	4/20 (20%)
tlr3	XP_002934448.3	PRK15370	<17..>158	CDD:185268	30/122 (25%)
		leucine-rich repeat	54..74	CDD:275380	5/19 (26%)
		leucine-rich repeat	75..98	CDD:275380	4/22 (18%)
		LRR	<95..428	CDD:443914	76/333 (23%)
		leucine-rich repeat	99..122	CDD:275380	3/22 (14%)
		leucine-rich repeat	123..146	CDD:275380	7/22 (32%)
		leucine-rich repeat	147..170	CDD:275380	5/22 (23%)
		leucine-rich repeat	171..196	CDD:275380	5/24 (21%)
		leucine-rich repeat	197..230	CDD:275380	10/32 (31%)
		leucine-rich repeat	231..273	CDD:275380	10/42 (24%)
		leucine-rich repeat	274..297	CDD:275380	8/22 (36%)
		leucine-rich repeat	298..319	CDD:275380	5/20 (25%)
		leucine-rich repeat	322..347	CDD:275380	0/24 (0%)
		PPP1R42	336..531	CDD:455733	42/231 (18%)
		leucine-rich repeat	348..371	CDD:275380	6/22 (27%)
		leucine-rich repeat	424..448	CDD:275380	5/23 (22%)
		PPP1R42	446..637	CDD:455733	38/197 (19%)
		leucine-rich repeat	449..472	CDD:275380	7/22 (32%)
		leucine-rich repeat	473..498	CDD:275380	8/56 (14%)
		leucine-rich repeat	499..522	CDD:275380	3/27 (11%)
		leucine-rich repeat	523..554	CDD:275380	6/39 (15%)
		leucine-rich repeat	555..578	CDD:275380	6/22 (27%)
		leucine-rich repeat	579..602	CDD:275380	6/14 (43%)
		leucine-rich repeat	603..623	CDD:275380
		PCC	607..>689	CDD:188093
		Tlr3_TMD	691..720	CDD:465595
		TIR	746..890	CDD:214587