DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fili and lrrtm4

DIOPT Version :9

Sequence 1:	NP_001369108.1	Gene:	Fili / 5740472	FlyBaseID:	FBgn0085397	Length:	789	Species:	Drosophila melanogaster
Sequence 2:	XP_031755133.1	Gene:	lrrtm4 / 100485215	XenbaseID:	XB-GENE-949702	Length:	622	Species:	Xenopus tropicalis

Alignment Length:	719	Identity:	169/719 - (23%)
Similarity:	271/719 - (37%)	Gaps:	182/719 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 LCGAIPVLLLLLLTLVILPPETTAFCPSKCQCLGGEANSRALCVDAALEDVPIQLNPETKYINLT 81
            |.|....||||...:|::.......||..|:|.|    ....|...|..|:|
Frog     9 LKGMSLTLLLLPALIVVMVVGAQKTCPKNCRCDG----KIVYCESHAFRDIP------------- 56

  Fly    82 VNRIRTLEFSLPFYMKLEILDLSQNIIETLGSKNFEYQSELRTLNLSRNLVSSLHKHAFKGLTNL 146
                                   |||  :.||:.         |:|..|.:..|..|.|.||..|
Frog    57 -----------------------QNI--SGGSQG---------LSLRYNSIKMLKSHQFSGLNQL 87

  Fly   147 LLLDLSFNRIETVHPTALSDLASLVELDLTNNNIVSLEDNCFKGMNTLEVLVFRNNRLLDVPASN 211
            :.|.|..|.|.||...|...:..|.||.|::|.|..|.::.|.                  |..|
Frog    88 VWLYLDHNYISTVDEDAFQGIRRLKELILSSNKISYLGNSTFH------------------PVPN 134

  Fly   212 LWHLHALKSLDMSLNLVEFVRNDSFEGLKELLALSVQGNVMSELDLSAFEGLISLKHLDLSDNNL 276
                  |::||:|.|.::.::::.|:||::||.|.::.|.:..:.:..|:...:|..|||..|.|
Frog   135 ------LRNLDLSYNKLQTLQSEQFKGLRKLLILHLRSNSLKTVPVRVFQDCRNLDFLDLGYNRL 193

  Fly   277 TMVPTQQLSKLSNLTYLNLGGNRFSQLPAVAFLNLFHLRELHLSRLDFLQRIDSRAFVDNTHLQT 341
            ..:.....:.|..|..|:|..|:||::....|..||:||.|:| :.:.::.|........:.||.
Frog   194 RSLSRNAFAGLLKLKELHLEHNQFSKVNFAHFPRLFNLRSLYL-QWNKIRSISQGLTWTWSALQN 257

  Fly   342 LHLNNNPQLSDIPMRLFQGNPNILEVYMQSNSL----QTLYSAQFPVDQLQKLYLGDNPLQCN-- 400
            |.|:.| .:.::....||..||:.::.:.||.|    |...:|..   .|..:.|..|..:|.
Frog   258 LDLSGN-DIQNLEPGTFQCLPNLQKLNLDSNKLTNVTQETLNAWI---SLTSITLSGNIWECTKK 318

  Fly   401 -CSLLWLWRLVTGNFEGVDPGMEHAAGGAVAALAKEADDEELAD--EATAVASTDDGVAALAAYI 462
             |.|::..:...||.|.:          .:.|..|....|::.|  |...:.:....:|...||.
Frog   319 ICPLVFWLKNFKGNKESI----------MICASPKNMQGEKVTDAVETYNICNETPVLATERAYP 373

  Fly   463 AEQHIVNALHTTEPSAYELATSSS----NRNSGILRMDRQQIGCDIWRDKVRTRRKLLTMSEGEI 523
            ..:.......|.:|:.|:|.:.||    :..|..|:                     ..|:|.|.
Frog   374 TTKPPPKPQFTPKPTIYKLESVSSTPYTSSPSPALQ---------------------TPMAEQEY 417

  Fly   524 TCPAHIVTVVCAVITCLLVAMIGISVLY--YLRF------------VKRRRKLLHE-----RGPM 569
            ...:....:..:|...|.|||| :.|:|  :.|:            :|||||...|     ..|:
Frog   418 EHVSFHKIIAGSVALFLSVAMI-LLVIYVSWKRYPASMKQLQQSSMMKRRRKKARESERQINSPL 481

  Fly   570 RT-----SKSIINVHDRILQGHNPGGLGLGMSM------------TLGGGNH---VNGLGMT--- 611
            :.     ..|.....|.::.|..|....:..|.            |:||...   :.....|
Frog   482 QEYYVDYKPSNTESMDVLVNGSGPCAYTISGSRECELCWSLRCVETIGGCQEDAIIQDKAETKAE 546

  Fly   612 LNYPHHAQTLQAHHHYHQAMP--LQSHGG-NGNHEYQQTTLPQLD--KLELER---YL------A 662
            ...|.|.:|: .:::|.|.|.  .|:|.. ..|..|::.:|.|.:  .|||.|   |:      |
Frog   547 QAVPRHIKTV-PYYNYDQPMVGYCQTHKSLLVNKGYEEMSLDQRETTNLELSRDQSYISTIARSA 610

  Fly   663 AQTI 666
            |.||
Frog   611 APTI 614

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fili	NP_001369108.1	leucine-rich repeat	75..97	CDD:275378	0/21 (0%)
		leucine-rich repeat	98..121	CDD:275380	5/22 (23%)
		LRR_8	120..180	CDD:404697	21/59 (36%)
		leucine-rich repeat	122..145	CDD:275380	8/22 (36%)
		leucine-rich repeat	146..169	CDD:275380	8/22 (36%)
		LRR	<161..>354	CDD:227223	50/192 (26%)
		leucine-rich repeat	170..193	CDD:275380	8/22 (36%)
		leucine-rich repeat	194..217	CDD:275380	2/22 (9%)
		leucine-rich repeat	218..265	CDD:275380	13/46 (28%)
		leucine-rich repeat	266..289	CDD:275380	7/22 (32%)
		leucine-rich repeat	290..313	CDD:275380	8/22 (36%)
		leucine-rich repeat	314..338	CDD:275380	5/23 (22%)
		LRR_8	337..397	CDD:404697	17/63 (27%)
		leucine-rich repeat	339..360	CDD:275380	6/20 (30%)
lrrtm4	XP_031755133.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24373
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100