DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fili and LOC100151059

DIOPT Version :9

Sequence 1:	NP_001369108.1	Gene:	Fili / 5740472	FlyBaseID:	FBgn0085397	Length:	789	Species:	Drosophila melanogaster
Sequence 2:	XP_017207970.1	Gene:	LOC100151059 / 100151059	-ID:	-	Length:	605	Species:	Danio rerio

Alignment Length:	521	Identity:	152/521 - (29%)
Similarity:	228/521 - (43%)	Gaps:	82/521 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 AIPVLLLLLLTLVILPPETTAFCPSKCQCLGGEANSRAL-CVDAALEDVPIQLNPETKYINLTVN 83
            |:..|.:|.|.|.:..|..:. ||.:|.|   .|..|:: |....|..||..:..||:.::|:.|
Zfish     6 AVSRLCVLGLLLALAAPSCSG-CPPRCDC---AAQLRSVSCQRRRLSAVPEGVPTETRLLDLSRN 66

  Fly    84 RIRTLEF-SLPFYMKLEILDLSQNIIETLGSKNFEYQSELRTLNLSRNLVSSLHKHAFKGLTNLL 147
            |:|.:.. .|..|.:||.||||:|:|.||....|.....||||.|..|.:..:...||..||||.
Zfish    67 RLRWVAAGDLAPYPRLEELDLSENLISTLEPNAFANLQALRTLRLRANQLKLVPMGAFARLTNLT 131

  Fly   148 LLDLSFNRIETVHPTALSDLASLVELDLTNNNIVSLEDNCFKGMNTLEVLVFRNNRLLDVPASNL 212
            .||||.|||..:......||.||..|::.:|::|.:....|.|:.:||.|......|..:....|
Zfish   132 TLDLSENRIVILLDFTFQDLRSLKNLEVGDNDLVYISHKAFSGLLSLEDLTMARCNLTSISGQTL 196

  Fly   213 WHLHALKSLDMSLNLVEFVRNDSFEGLKELLALSVQG----NVMSELDLSAFEGLISLKHLDLSD 273
            .:|..|.:|.:....:..:...:|..|..|..|.:..    ..:|.|   :|:|| :|..|.:::
Zfish   197 SYLRGLVTLRLRHLSISTLEEQNFRKLTALRGLEIHDWPFLEFISPL---SFQGL-NLSWLFITN 257

  Fly   274 NNLTMVPTQQLSKLSNLTYLNLGGNRFSQLPAVAFLNLFHLRELHLSRLDFLQRIDSRAFVDNTH 338
            .|:|.||:.....|:.||.|||..|..|.|.:.||.:|..|:|||:...:.| .::..|......
Zfish   258 TNITSVPSASFRNLAYLTALNLSYNPISTLESWAFRDLIRLKELHMVSTNLL-TVEPHALGGLRQ 321

  Fly   339 LQTLHLNNNPQLSDIPMRLFQGNPNILEVYMQSNSLQTLYSAQF-PVDQLQKLYLGDNPLQCNCS 402
            ::.|:|:|                         |.|.||..:.| .|:.|:.|.:..|||.|:|.
Zfish   322 IRVLNLSN-------------------------NDLVTLEESSFHSVNSLETLRVDGNPLSCDCR 361

  Fly   403 LLW-LWRLVTGNFEGVDPGMEHAAGGAVAALAKEADDEELADEATAVASTDDGVAALAAYIAEQ- 465
            ||| |.|..|.||:|..|         |.|...|.....|:      ..||   :||..|...|
Zfish   362 LLWILQRRRTLNFDGKMP---------VCAGPPEVQGYLLS------MFTD---SALFDYFTCQK 408

  Fly   466 -HIVN------ALHTTEPSAYELATSSSNRNSGILRMDRQQIGCDIWRDKVRTRRKLLTMSEGEI 523
             .|.|      .:|..:|.::            :.|.:.:.....||...  .||::.:.|.|.:
Zfish   409 PKIRNRKMQQVMVHEGQPVSF------------LCRAEGEPTPAIIWISP--QRRRITSKSNGRV 459

  Fly   524 T 524
            |
Zfish   460 T 460

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fili	NP_001369108.1	leucine-rich repeat	75..97	CDD:275378	7/22 (32%)
		leucine-rich repeat	98..121	CDD:275380	11/22 (50%)
		LRR_8	120..180	CDD:404697	25/59 (42%)
		leucine-rich repeat	122..145	CDD:275380	9/22 (41%)
		leucine-rich repeat	146..169	CDD:275380	10/22 (45%)
		LRR	<161..>354	CDD:227223	53/196 (27%)
		leucine-rich repeat	170..193	CDD:275380	6/22 (27%)
		leucine-rich repeat	194..217	CDD:275380	6/22 (27%)
		leucine-rich repeat	218..265	CDD:275380	11/50 (22%)
		leucine-rich repeat	266..289	CDD:275380	7/22 (32%)
		leucine-rich repeat	290..313	CDD:275380	11/22 (50%)
		leucine-rich repeat	314..338	CDD:275380	6/23 (26%)
		LRR_8	337..397	CDD:404697	12/60 (20%)
		leucine-rich repeat	339..360	CDD:275380	3/20 (15%)
LOC100151059	XP_017207970.1	LRRNT	26..60	CDD:214470	12/37 (32%)
		leucine-rich repeat	37..56	CDD:275380	5/18 (28%)
		leucine-rich repeat	58..81	CDD:275380	7/22 (32%)
		LRR_RI	61..332	CDD:238064	90/300 (30%)
		LRR_8	80..140	CDD:290566	28/59 (47%)
		leucine-rich repeat	82..105	CDD:275380	11/22 (50%)
		leucine-rich repeat	106..129	CDD:275380	9/22 (41%)
		LRR_8	128..188	CDD:290566	22/59 (37%)
		leucine-rich repeat	130..153	CDD:275380	10/22 (45%)
		leucine-rich repeat	154..177	CDD:275380	6/22 (27%)
		leucine-rich repeat	178..201	CDD:275380	6/22 (27%)
		leucine-rich repeat	202..225	CDD:275380	4/22 (18%)
		leucine-rich repeat	226..249	CDD:275380	7/26 (27%)
		LRR_8	249..308	CDD:290566	22/58 (38%)
		leucine-rich repeat	250..273	CDD:275380	7/22 (32%)
		leucine-rich repeat	274..295	CDD:275380	10/20 (50%)
		LRR_8	297..356	CDD:290566	18/84 (21%)
		leucine-rich repeat	298..321	CDD:275380	6/23 (26%)
		leucine-rich repeat	322..342	CDD:275380	8/44 (18%)
		leucine-rich repeat	346..358	CDD:275378	5/11 (45%)
		TPKR_C2	354..394	CDD:301599	19/54 (35%)
		I-set	409..499	CDD:254352	12/66 (18%)
		Ig	424..492	CDD:299845	9/51 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24373
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	3.010