DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fili and flrt3

DIOPT Version :9

Sequence 1:	NP_001369108.1	Gene:	Fili / 5740472	FlyBaseID:	FBgn0085397	Length:	789	Species:	Drosophila melanogaster
Sequence 2:	NP_001116922.1	Gene:	flrt3 / 100144692	XenbaseID:	XB-GENE-490901	Length:	648	Species:	Xenopus tropicalis

Alignment Length:	391	Identity:	101/391 - (25%)
Similarity:	155/391 - (39%)	Gaps:	96/391 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 LLLTLVILPPETTAF-CPSKCQCLGGEANSRALCVDAALEDVPIQLNPETKYINLTVNRIRT--L 88
            |||...|.|....|. |||.|:|.||    ...|.|..|..:|..:..:...:.|..|:|..  :
Frog    15 LLLLFRISPQYVNAKPCPSVCRCDGG----FIYCNDRDLTSIPSGIPDDATTLYLQNNQINNAGI 75

  Fly    89 EFSLPFYMKLEILDLSQNIIETLGSKNFEYQSELRTLNLSRNLVSSLHKHAFKGLTNLLLLDLSF 153
            ...|....|:|.:.|.:|.::..            .:||.:| |..||              |..
Frog    76 PSDLRGLDKVERIYLYRNSLDEF------------PINLPKN-VKELH--------------LQE 113

  Fly   154 NRIETVHPTALSDLASLVELDLTNNNI--VSLEDNCFKGMNTLEVLVFRNNRLLDVPASNLWHL- 215
            |.|.|:...|||.:.|:.||.|.:|::  ||:||..|:....|.:|....|.|..:|    |.|
Frog   114 NNIRTITYDALSQIPSIEELHLDDNSVSAVSIEDGAFRDNIFLRLLFLSRNHLSTIP----WGLP 174

  Fly   216 HALKSLDMSLNLVEFVRNDSFEGLKELLALSVQGNVMSELDLS--AFEGLISLKHLDLSDNNLTM 278
            ..::.|.:..|.:..:...|.:.|..|..|.:.||:::...|.  .|..||:|..|.|..|:||.
Frog   175 RTIEELRLDDNRISTIAEISLQDLTNLKRLVLDGNLLNNNGLGERVFMNLINLTELSLVRNSLTS 239

  Fly   279 VPTQQLSKLSNLTYLNLGGNRFSQLPAVAFLNLFHLRELHLSRLDFLQRIDSRAFVDNTHLQTLH 343
            .|.            ||.|....:|         :|:|.|::      .:...||.|.|.|..|.
Frog   240 PPA------------NLPGTNLRKL---------YLQENHMN------YVPPNAFADLTQLYRLD 277

  Fly   344 LNNNPQLSDIPMRLFQGNPNILEVYMQSNSLQTLYSAQFPVDQLQKLYLGDNPLQCNCSLLWL-- 406
            ::|| .::.:|..:|.                       .:|.|.:|:|.:||..|.|.:.|:
Frog   278 MSNN-NITALPQGIFD-----------------------DLDNLTQLFLRNNPWYCGCKMKWVRD 318

  Fly   407 W 407
            |
Frog   319 W 319

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fili	NP_001369108.1	leucine-rich repeat	75..97	CDD:275378	4/23 (17%)
		leucine-rich repeat	98..121	CDD:275380	3/22 (14%)
		LRR_8	120..180	CDD:404697	18/59 (31%)
		leucine-rich repeat	122..145	CDD:275380	6/22 (27%)
		leucine-rich repeat	146..169	CDD:275380	7/22 (32%)
		LRR	<161..>354	CDD:227223	54/197 (27%)
		leucine-rich repeat	170..193	CDD:275380	9/24 (38%)
		leucine-rich repeat	194..217	CDD:275380	7/23 (30%)
		leucine-rich repeat	218..265	CDD:275380	11/48 (23%)
		leucine-rich repeat	266..289	CDD:275380	7/22 (32%)
		leucine-rich repeat	290..313	CDD:275380	4/22 (18%)
		leucine-rich repeat	314..338	CDD:275380	6/23 (26%)
		LRR_8	337..397	CDD:404697	12/59 (20%)
		leucine-rich repeat	339..360	CDD:275380	6/20 (30%)
flrt3	NP_001116922.1	PRK15370	<44..>305	CDD:185268	82/342 (24%)
		LRR 1. /evidence=ECO:0000255	58..82		4/23 (17%)
		leucine-rich repeat	61..84	CDD:275380	4/22 (18%)
		LRR 2. /evidence=ECO:0000255	83..105		6/33 (18%)
		leucine-rich repeat	85..105	CDD:275380	5/31 (16%)
		leucine-rich repeat	106..129	CDD:275380	10/36 (28%)
		LRR 3. /evidence=ECO:0000255	107..126		8/32 (25%)
		LRR 4. /evidence=ECO:0000255	127..152		10/24 (42%)
		leucine-rich repeat	130..155	CDD:275380	9/24 (38%)
		LRR 5. /evidence=ECO:0000255	154..179		7/28 (25%)
		leucine-rich repeat	156..176	CDD:275380	7/23 (30%)
		leucine-rich repeat	177..200	CDD:275380	4/22 (18%)
		LRR 6. /evidence=ECO:0000255	181..197		2/15 (13%)
		LRR 7. /evidence=ECO:0000255	198..223		7/24 (29%)
		leucine-rich repeat	201..226	CDD:275380	7/24 (29%)
		LRR 8. /evidence=ECO:0000255	225..246		10/32 (31%)
		leucine-rich repeat	227..248	CDD:275380	10/32 (31%)
		LRR 9. /evidence=ECO:0000255	247..269		6/36 (17%)
		leucine-rich repeat	249..272	CDD:275380	7/37 (19%)
		LRR 10. /evidence=ECO:0000255	270..293		7/46 (15%)
		leucine-rich repeat	273..296	CDD:275380	6/46 (13%)
		PCC	277..>354	CDD:188093	14/67 (21%)
		FN3	413..476	CDD:214495
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	624..648
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910