Protein Alignment Fili and elfn1b

DIOPT Version :10

• Sequence 1: NP_001369108.1
• Gene: Fili / 5740472
• FlyBaseID: FBgn0085397
• Length: 789
• Species: Drosophila melanogaster
• Sequence 2: XP_001920383.1
• Gene: elfn1b / 100144401
• ZFINID: ZDB-GENE-080327-21
• Length: 814
• Species: Danio rerio
• Alignment Length: 877
• Identity: 161/877 - (18%)
• Similarity: 283/877 - (32%)
• Gaps: 319/877 - (36%)

  Fly    17 LCGAIPVLLLLLLTLVILPPETTAFCPSKCQCLGGEANS--RALCV--DAALEDVPIQLNPETKY 77
            ||.|:.::.|.|..:.::..:        |..:.||...  .|:|.  ....|::|:.:|.....
Zfish    25 LCWAVALVFLSLTRVPVVQGD--------CWLIEGEKGFVWLAICSQNQPPYENIPMHINSTIVD 81

  Fly    78 INLTVNRIRTLEFSLPFYMKLEILDLSQNIIETLGSKNFEYQSELRTLNLSRNLVSSLHKHAFKG 142
            :.|..|:||::.||          .||:     .|  |..|      |||::|.:|.:...||..
Zfish    82 LRLNENKIRSIHFS----------SLSR-----FG--NLTY------LNLTKNDISYIEDGAFSA 123

  Fly   143 LTNLLLLDLSFNRIETVHPTALSDLASLVELDLTNNNIVSLEDNCFKGMNTLEVLVFRNNRLLDV 207
            ..||.:|.:.||::.                        :|.:...:|:..|:.|..:.|.:..|
Zfish   124 QFNLQVLQIGFNKMR------------------------NLTEGMLRGLGRLQYLYLQANLIETV 164

  Fly   208 PASNLWHLHALKSLDMSLNLVEFVRNDSFEGLKELLALSVQGNVMS-ELDLSAFEGLISLKHLDL 271
            .|:..|...|::::|:|:|.::.:...:|.||.:|....:..|..| ..:|..|     |:.
Zfish   165 TANAFWECPAIENIDLSMNRIQQLDGATFRGLSKLTTCELYANPFSCSCELLGF-----LRW--- 221

  Fly   272 SDNNLTMVPTQQLSKLSNLTYLNLGG-NRFSQLPAV-AFLNLFHLRELHLSRLDFLQRIDSRAFV 334
                |...|.:...:::..|.....| :..||.|.: .:.|.||             .:.|....
Zfish   222 ----LVAFPNRTSERMACDTPAGFSGYSLLSQNPRMPRYRNAFH-------------ALSSVCTD 269

  Fly   335 DNTHLQTLHLNNNPQLSDIPMRLFQGNP----------------NILEVYMQSNS---------- 373
            ||.   |.:|:.:|. ..||.||...:|                :|...::.|::
Zfish   270 DNV---TPYLHGSPD-GGIPTRLPDLSPCGLDDCSSGTFPEETISISPTFLDSDARPIMKLKEVT 330

  Fly   374 -LQTLYSAQFPVDQLQKLYLGDNPLQCNCSLLWLWRLVTGNFEGVDPGMEHAAGGAVAALAKEAD 437
             ...:.:.|.| :..:|:|:                ||..|         ::....:..|..:.:
Zfish   331 HTSAVITIQIP-NPFRKMYI----------------LVLYN---------NSFFTDIQNLKSQRE 369

  Fly   438 DEELADEATAVASTDDGVAALAAYIAEQHIVNALHTTEPSAYELATSSSNRNSGILRMDRQQIGC 502
            :.||                       |::.:  ||.    |....:|.
Zfish   370 EIEL-----------------------QNLKS--HTN----YTYCVASI---------------- 389

  Fly   503 DIWRDKVRTRRKLLTMSEGEITCPAHIVT------VVCAVITCLLVAMIGISVLYYLRFVKRRRK 561
               |:.:|.....||:|.|..|....:|.      .:..::.||...:|.:.|:.:   ..|:||
Zfish   390 ---RNSLRFNHTCLTISTGPRTLQERVVNDSTATHYIMTILGCLFGMLIVLGVVVH---CLRKRK 448

  Fly   562 LLHERGPMRTSKSIINVHDRILQGHNPGGLGLGMSMTLGGGNHVNGLGMTLNYPHHAQTLQAHHH 626
            ...|    ..||.:..:...:::      :..|..:..|          |::.....|.|.|...
Zfish   449 KQDE----PKSKKLEKMKRNLIE------MKYGTELEQG----------TISQLSQKQILSAGET 493

  Fly   627 YHQAMP------------LQSHGG-----NGNH--------------------EYQQTTLPQLDK 654
            . |.||            :|...|     .||:                    |..|.::.::..
Zfish   494 V-QRMPYLPAASDTDQYKMQEISGTPKTTKGNYMEVRSEQPERSIRECSVPPSETSQGSVAEIST 557

  Fly   655 LELERYLAAQTIANEYRALKPWELPVKEADD------EP------EH----------LYERFDHY 697
            :..|.....|.|.|...|||......:.|..      ||      ||          :|:...|:
Zfish   558 IAKEVDKVNQIINNCIDALKSDSTSFQTAKSGAVSTAEPQLVLISEHPPGKSGFLSPVYKGGYHH 622

  Fly   698 EYPDTHTMSKLKQAASLNHSNSSAGP-------------------SPVPPSSGKPHVVYVXRG-- 741
            .....|:|...::.||.:.|.|...|                   ||...|.    ::.|...
Zfish   623 PLQRHHSMDAPQKRASTSSSGSLRSPRSFRSEGAYRSESKYIEKASPQDESG----IITVTPAAA 683

  Fly   742 --RGTGERVSQINTDIEMVGLNHLHLH---HH 768
              |...||:.|.:        .|.|.:   ||
Zfish   684 ILRAEAERIRQYS--------EHRHSYPGPHH 707

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Fili	NP_001369108.1	LRR	71..>348	CDD:443914	60/279 (22%)
		leucine-rich repeat	75..97	CDD:275378	6/21 (29%)
		leucine-rich repeat	98..121	CDD:275380	5/22 (23%)
		leucine-rich repeat	122..145	CDD:275380	7/22 (32%)
		leucine-rich repeat	146..169	CDD:275380	4/22 (18%)
		leucine-rich repeat	170..193	CDD:275380	2/22 (9%)
		leucine-rich repeat	194..217	CDD:275380	6/22 (27%)
		leucine-rich repeat	218..265	CDD:275380	11/47 (23%)
		leucine-rich repeat	266..289	CDD:275380	3/22 (14%)
		leucine-rich repeat	290..313	CDD:275380	6/24 (25%)
		leucine-rich repeat	314..338	CDD:275380	3/23 (13%)
		LRR_8	337..397	CDD:404697	14/86 (16%)
		leucine-rich repeat	339..360	CDD:275380	7/20 (35%)
elfn1b	XP_001920383.1	LRR	<68..>210	CDD:443914	43/188 (23%)
		leucine-rich repeat	82..102	CDD:275378	9/36 (25%)
		leucine-rich repeat	103..126	CDD:275378	8/28 (29%)
		leucine-rich repeat	127..150	CDD:275378	6/46 (13%)
		leucine-rich repeat	151..174	CDD:275378	6/22 (27%)
		leucine-rich repeat	175..188	CDD:275378	3/12 (25%)
		PCC	179..>247	CDD:188093	16/79 (20%)