DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fili and elfn1b

DIOPT Version :9

Sequence 1:	NP_001369108.1	Gene:	Fili / 5740472	FlyBaseID:	FBgn0085397	Length:	789	Species:	Drosophila melanogaster
Sequence 2:	XP_001920383.1	Gene:	elfn1b / 100144401	ZFINID:	ZDB-GENE-080327-21	Length:	814	Species:	Danio rerio

Alignment Length:	877	Identity:	161/877 - (18%)
Similarity:	283/877 - (32%)	Gaps:	319/877 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 LCGAIPVLLLLLLTLVILPPETTAFCPSKCQCLGGEANS--RALCV--DAALEDVPIQLNPETKY 77
            ||.|:.::.|.|..:.::..:        |..:.||...  .|:|.  ....|::|:.:|.....
Zfish    25 LCWAVALVFLSLTRVPVVQGD--------CWLIEGEKGFVWLAICSQNQPPYENIPMHINSTIVD 81

  Fly    78 INLTVNRIRTLEFSLPFYMKLEILDLSQNIIETLGSKNFEYQSELRTLNLSRNLVSSLHKHAFKG 142
            :.|..|:||::.||          .||:     .|  |..|      |||::|.:|.:...||..
Zfish    82 LRLNENKIRSIHFS----------SLSR-----FG--NLTY------LNLTKNDISYIEDGAFSA 123

  Fly   143 LTNLLLLDLSFNRIETVHPTALSDLASLVELDLTNNNIVSLEDNCFKGMNTLEVLVFRNNRLLDV 207
            ..||.:|.:.||::.                        :|.:...:|:..|:.|..:.|.:..|
Zfish   124 QFNLQVLQIGFNKMR------------------------NLTEGMLRGLGRLQYLYLQANLIETV 164

  Fly   208 PASNLWHLHALKSLDMSLNLVEFVRNDSFEGLKELLALSVQGNVMS-ELDLSAFEGLISLKHLDL 271
            .|:..|...|::::|:|:|.::.:...:|.||.:|....:..|..| ..:|..|     |:.
Zfish   165 TANAFWECPAIENIDLSMNRIQQLDGATFRGLSKLTTCELYANPFSCSCELLGF-----LRW--- 221

  Fly   272 SDNNLTMVPTQQLSKLSNLTYLNLGG-NRFSQLPAV-AFLNLFHLRELHLSRLDFLQRIDSRAFV 334
                |...|.:...:::..|.....| :..||.|.: .:.|.||             .:.|....
Zfish   222 ----LVAFPNRTSERMACDTPAGFSGYSLLSQNPRMPRYRNAFH-------------ALSSVCTD 269

  Fly   335 DNTHLQTLHLNNNPQLSDIPMRLFQGNP----------------NILEVYMQSNS---------- 373
            ||.   |.:|:.:|. ..||.||...:|                :|...::.|::
Zfish   270 DNV---TPYLHGSPD-GGIPTRLPDLSPCGLDDCSSGTFPEETISISPTFLDSDARPIMKLKEVT 330

  Fly   374 -LQTLYSAQFPVDQLQKLYLGDNPLQCNCSLLWLWRLVTGNFEGVDPGMEHAAGGAVAALAKEAD 437
             ...:.:.|.| :..:|:|:                ||..|         ::....:..|..:.:
Zfish   331 HTSAVITIQIP-NPFRKMYI----------------LVLYN---------NSFFTDIQNLKSQRE 369

  Fly   438 DEELADEATAVASTDDGVAALAAYIAEQHIVNALHTTEPSAYELATSSSNRNSGILRMDRQQIGC 502
            :.||                       |::.:  ||.    |....:|.
Zfish   370 EIEL-----------------------QNLKS--HTN----YTYCVASI---------------- 389

  Fly   503 DIWRDKVRTRRKLLTMSEGEITCPAHIVT------VVCAVITCLLVAMIGISVLYYLRFVKRRRK 561
               |:.:|.....||:|.|..|....:|.      .:..::.||...:|.:.|:.:   ..|:||
Zfish   390 ---RNSLRFNHTCLTISTGPRTLQERVVNDSTATHYIMTILGCLFGMLIVLGVVVH---CLRKRK 448

  Fly   562 LLHERGPMRTSKSIINVHDRILQGHNPGGLGLGMSMTLGGGNHVNGLGMTLNYPHHAQTLQAHHH 626
            ...|    ..||.:..:...:::      :..|..:..|          |::.....|.|.|...
Zfish   449 KQDE----PKSKKLEKMKRNLIE------MKYGTELEQG----------TISQLSQKQILSAGET 493

  Fly   627 YHQAMP------------LQSHGG-----NGNH--------------------EYQQTTLPQLDK 654
            . |.||            :|...|     .||:                    |..|.::.::..
Zfish   494 V-QRMPYLPAASDTDQYKMQEISGTPKTTKGNYMEVRSEQPERSIRECSVPPSETSQGSVAEIST 557

  Fly   655 LELERYLAAQTIANEYRALKPWELPVKEADD------EP------EH----------LYERFDHY 697
            :..|.....|.|.|...|||......:.|..      ||      ||          :|:...|:
Zfish   558 IAKEVDKVNQIINNCIDALKSDSTSFQTAKSGAVSTAEPQLVLISEHPPGKSGFLSPVYKGGYHH 622

  Fly   698 EYPDTHTMSKLKQAASLNHSNSSAGP-------------------SPVPPSSGKPHVVYVXRG-- 741
            .....|:|...::.||.:.|.|...|                   ||...|.    ::.|...
Zfish   623 PLQRHHSMDAPQKRASTSSSGSLRSPRSFRSEGAYRSESKYIEKASPQDESG----IITVTPAAA 683

  Fly   742 --RGTGERVSQINTDIEMVGLNHLHLH---HH 768
              |...||:.|.:        .|.|.:   ||
Zfish   684 ILRAEAERIRQYS--------EHRHSYPGPHH 707

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fili	NP_001369108.1	leucine-rich repeat	75..97	CDD:275378	6/21 (29%)
		leucine-rich repeat	98..121	CDD:275380	5/22 (23%)
		LRR_8	120..180	CDD:404697	12/59 (20%)
		leucine-rich repeat	122..145	CDD:275380	7/22 (32%)
		leucine-rich repeat	146..169	CDD:275380	4/22 (18%)
		LRR	<161..>354	CDD:227223	37/195 (19%)
		leucine-rich repeat	170..193	CDD:275380	2/22 (9%)
		leucine-rich repeat	194..217	CDD:275380	6/22 (27%)
		leucine-rich repeat	218..265	CDD:275380	11/47 (23%)
		leucine-rich repeat	266..289	CDD:275380	3/22 (14%)
		leucine-rich repeat	290..313	CDD:275380	6/24 (25%)
		leucine-rich repeat	314..338	CDD:275380	3/23 (13%)
		LRR_8	337..397	CDD:404697	14/86 (16%)
		leucine-rich repeat	339..360	CDD:275380	7/20 (35%)
elfn1b	XP_001920383.1	leucine-rich repeat	82..102	CDD:275378	9/36 (25%)
		LRR_8	102..161	CDD:316378	19/88 (22%)
		leucine-rich repeat	103..126	CDD:275378	8/28 (29%)
		leucine-rich repeat	127..150	CDD:275378	6/46 (13%)
		leucine-rich repeat	151..174	CDD:275378	6/22 (27%)
		leucine-rich repeat	175..188	CDD:275378	3/12 (25%)
		PCC	179..>247	CDD:188093	16/79 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24373
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.100