DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fili and LRRC70

DIOPT Version :9

Sequence 1:	NP_001369108.1	Gene:	Fili / 5740472	FlyBaseID:	FBgn0085397	Length:	789	Species:	Drosophila melanogaster
Sequence 2:	NP_852607.3	Gene:	LRRC70 / 100130733	HGNCID:	35155	Length:	622	Species:	Homo sapiens

Alignment Length:	643	Identity:	156/643 - (24%)
Similarity:	246/643 - (38%)	Gaps:	117/643 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 LCG---AIPVLLLLLLT---LVILPPETTAFCPSKCQ-CLGGEANSRALCVDAALEDVPIQLNPE 74
            :||   ::|.|.|.|:.   |::|..:....|.|.|| |.|.:.|    |.:..|..:|......
Human     1 MCGLQFSLPCLRLFLVVTCYLLLLLHKEILGCSSVCQLCTGRQIN----CRNLGLSSIPKNFPES 61

  Fly    75 TKYINLTVNRIRTL-EFSLPFYMKLEILDLSQNIIETLGSKNFEYQSELRTLNLSRNLVSSLHKH 138
            |.::.||.|.|..: |..|.....|..|.|..:.|..:..|.|.....|..|.|:.|.:..|...
Human    62 TVFLYLTGNNISYINESELTGLHSLVALYLDNSNILYVYPKAFVQLRHLYFLFLNNNFIKRLDPG 126

  Fly   139 AFKGLTNLLLLDLSFNRIETVHPTALSDLASLVELDLTNNNIVSLEDNCFKGMNTLEVLVFRNNR 203
            .||||.||..|.|.:|::..|.....:||.|:..|:|..|.:..|....|.||..|.:|...||.
Human   127 IFKGLLNLRNLYLQYNQVSFVPRGVFNDLVSVQYLNLQRNRLTVLGSGTFVGMVALRILDLSNNN 191

  Fly   204 LLDVPASNLWHLHALKSLDMSLNLVEFVRNDSFEGLKELLALSVQGNVMSELDLSAFEGLISLKH 268
            :|.:..|...||..|..|.:..|.:..|.:::||.||.|..||:..|.:..:...||:||.:|::
Human   192 ILRISESGFQHLENLACLYLGSNNLTKVPSNAFEVLKSLRRLSLSHNPIEAIQPFAFKGLANLEY 256

  Fly   269 LDLSDNNLTMVPTQQLSKLSNLTYLNLGGNRFSQLPAVAFLNLFHLRELHLSRLDFLQRIDSRAF 333
            |.|.::.:..|.....|.::||.:|.|..|....|.:..|..|.:|..|.|.|...:. ||:..|
Human   257 LLLKNSRIRNVTRDGFSGINNLKHLILSHNDLENLNSDTFSLLKNLIYLKLDRNRIIS-IDNDTF 320

  Fly   334 VD-NTHLQTLHLNNNPQLSDIPMRLFQGNPNILEVYMQSNSLQTLYSAQFPVDQLQKLYLGDNPL 397
            .: ...|:.|:|:.|        .|...:|.:|:                |:..|..|....||.
Human   321 ENMGASLKILNLSFN--------NLTALHPRVLK----------------PLSSLIHLQANSNPW 361

  Fly   398 QCNCSLL----WL----------------------------------------WRLVTGNFEGVD 418
            :|||.||    ||                                        |.:|.      .
Human   362 ECNCKLLGLRDWLASSAITLNIYCQNPPSMRGRALRYINITNCVTSSINVSRAWAVVK------S 420

  Fly   419 PGMEHAAGGAVAALAK-EADDEELADEATAVASTDDGVAALAA--YIAEQHIVNALHTTE--PSA 478
            |.:.|.....:.|..| ..:...|.:..|...:..:.:....|  :..|....|.|.||.  |..
Human   421 PHIHHKTTALMMAWHKVTTNGSPLENTETENITFWERIPTSPAGRFFQENAFGNPLETTAVLPVQ 485

  Fly   479 YELATS---SSNRNSGILRMDRQQIGCDIWRDKVRTRRKLLTMSEGEITCPAHIVTVVCAVITCL 540
            .:|.||   :..:||.:........|          :..|:...|.|....|..:.:...::.|:
Human   486 IQLTTSVTLNLEKNSALPNDAASMSG----------KTSLICTQEVEKLNEAFDILLAFFILACV 540

  Fly   541 LVAMIGISVLYYLRFVK-----RRRKL----LHERGPMRTSKSIINVHDRILQGHNPG 589
            |:..:...|:.:.:.:|     |..:|    .::......:.||.|.....|:  :||
Human   541 LIIFLIYKVVQFKQKLKASENSRENRLEYYSFYQSARYNVTASICNTSPNSLE--SPG 596

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fili	NP_001369108.1	leucine-rich repeat	75..97	CDD:275378	7/22 (32%)
		leucine-rich repeat	98..121	CDD:275380	6/22 (27%)
		LRR_8	120..180	CDD:404697	21/59 (36%)
		leucine-rich repeat	122..145	CDD:275380	9/22 (41%)
		leucine-rich repeat	146..169	CDD:275380	7/22 (32%)
		LRR	<161..>354	CDD:227223	58/193 (30%)
		leucine-rich repeat	170..193	CDD:275380	7/22 (32%)
		leucine-rich repeat	194..217	CDD:275380	8/22 (36%)
		leucine-rich repeat	218..265	CDD:275380	16/46 (35%)
		leucine-rich repeat	266..289	CDD:275380	5/22 (23%)
		leucine-rich repeat	290..313	CDD:275380	7/22 (32%)
		leucine-rich repeat	314..338	CDD:275380	7/24 (29%)
		LRR_8	337..397	CDD:404697	11/59 (19%)
		leucine-rich repeat	339..360	CDD:275380	5/20 (25%)
LRRC70	NP_852607.3	LRRNT	31..62	CDD:214470	10/34 (29%)
		LRR 1	61..82		7/20 (35%)
		leucine-rich repeat	65..85	CDD:275380	6/19 (32%)
		LRR_8	85..144	CDD:290566	20/58 (34%)
		LRR 2	85..106		6/20 (30%)
		leucine-rich repeat	86..109	CDD:275380	6/22 (27%)
		LRR 3	109..130		6/20 (30%)
		leucine-rich repeat	110..133	CDD:275380	9/22 (41%)
		LRR_8	133..192	CDD:290566	20/58 (34%)
		LRR 4	133..154		6/20 (30%)
		leucine-rich repeat	134..157	CDD:275380	7/22 (32%)
		LRR 5	157..178		6/20 (30%)
		leucine-rich repeat	158..181	CDD:275380	7/22 (32%)
		LRR_RI	<159..340	CDD:238064	56/189 (30%)
		LRR 6	181..202		6/20 (30%)
		LRR_8	182..240	CDD:290566	20/57 (35%)
		leucine-rich repeat	182..205	CDD:275380	8/22 (36%)
		LRR 7	205..226		5/20 (25%)
		leucine-rich repeat	206..229	CDD:275380	7/22 (32%)
		LRR_8	228..288	CDD:290566	19/59 (32%)
		LRR 8	229..250		6/20 (30%)
		leucine-rich repeat	230..253	CDD:275380	8/22 (36%)
		LRR 9	253..274		4/20 (20%)
		leucine-rich repeat	254..277	CDD:275380	5/22 (23%)
		LRR_8	277..337	CDD:290566	19/68 (28%)
		LRR 10	277..298		7/20 (35%)
		leucine-rich repeat	278..301	CDD:275380	7/22 (32%)
		LRR 11	301..322		7/21 (33%)
		leucine-rich repeat	302..326	CDD:275380	7/24 (29%)
		LRR 12	326..347		7/44 (16%)
		leucine-rich repeat	327..348	CDD:275380	7/44 (16%)
		LRRCT	359..398	CDD:214507	9/38 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	2	1.870