DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fili and lrrn1-like

DIOPT Version :9

Sequence 1:	NP_001369108.1	Gene:	Fili / 5740472	FlyBaseID:	FBgn0085397	Length:	789	Species:	Drosophila melanogaster
Sequence 2:	NP_001106456.1	Gene:	lrrn1-like / 100127637	XenbaseID:	XB-GENE-492890	Length:	738	Species:	Xenopus tropicalis

Alignment Length:	444	Identity:	123/444 - (27%)
Similarity:	193/444 - (43%)	Gaps:	100/444 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 HTRVTATTRSRP--WL--CGAIPVLLLLLLTLVILPPETTAFCPSKCQC----------LGGEAN 54
            ||....:.|.:|  |:  |     |.:::|..|..  .|...||.:|.|          :..||.
Frog     3 HTNPARSQRMKPPLWMETC-----LFVIVLHSVFF--STLGVCPPQCVCETRPWFTPQSVYHEAK 60

  Fly    55 SRALCVDAALEDVPIQLNPETKYINLTVNRIRTLEFSLPFYMKLEILDLSQN---IIETLGSKNF 116
            : ..|.|..|..:|..|:.:.:.:.|..|:|..|.:.|.....|..||||||   .|:.||..|.
Frog    61 T-VDCNDLLLTHIPENLSTDIQVLLLQSNKISHLTWELQELSNLTELDLSQNHFQSIDDLGVSNL 124

  Fly   117 EYQSELRTLNLSRNLVSSLHKHAFKGLTNLLLLDLSFNRIETVHPTALSDLASLVELDLTNNNIV 181
               |:|.||.|..|.:..|..::.|.|.:|..|.::.|:|..:.|.|.|.|..|:.|.|..|.:.
Frog   125 ---SQLITLYLEENQLRELPDYSLKDLGSLEELYINHNQISYIGPRAFSGLGRLLRLHLNANRLE 186

  Fly   182 SLEDNCFKGMNTLEVLVFRNNRLLDVPASNLWHLHALKSLDMSLNLVEFVRNDSFEGLKELLALS 246
            .::...|:.:..||:|:...|     |.:      ||:||             :|:.|..|.:|.
Frog   187 IIDPRWFEDLPNLEILMVGEN-----PVT------ALQSL-------------NFQPLGRLHSLV 227

  Fly   247 VQGNVMSELDLSAFEGLISLKHLDLSDNNLTMVPTQQLSKLSNLTYLNLGGNRFSQLPAVAFLNL 311
            :.|..:..:..:||:||..|:.|...||.||.||.:.|..|..|.:|:|..|...::....|..:
Frog   228 LAGMELEHIPENAFQGLDYLESLSFFDNRLTEVPKEALKNLKLLKFLDLNKNPIPEIRGGDFTGM 292

  Fly   312 FHLRELHLSRLDFLQRIDSRAFVDNTHLQTLHLNNNPQLS------------------------- 351
            .||.||.|:.::.|:|:::.||.|...|..|.:.|||:||
Frog   293 EHLEELSLNSMEELERVEAEAFQDLPELIKLEMCNNPRLSYLDPEAFSSNLGALKTLLLNNNRLA 357

  Fly   352 DIPMRLFQGNPNILEVYMQSNSLQTLYSAQFPVDQLQKLYLGDNPLQCNCSLLW 405
            .:|:::||..|.:||:        :|||               ||::|:|...|
Frog   358 MVPLKIFQALPGLLEI--------SLYS---------------NPIRCDCQNCW 388

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fili	NP_001369108.1	leucine-rich repeat	75..97	CDD:275378	5/21 (24%)
		leucine-rich repeat	98..121	CDD:275380	11/25 (44%)
		LRR_8	120..180	CDD:404697	21/59 (36%)
		leucine-rich repeat	122..145	CDD:275380	8/22 (36%)
		leucine-rich repeat	146..169	CDD:275380	8/22 (36%)
		LRR	<161..>354	CDD:227223	59/217 (27%)
		leucine-rich repeat	170..193	CDD:275380	5/22 (23%)
		leucine-rich repeat	194..217	CDD:275380	5/22 (23%)
		leucine-rich repeat	218..265	CDD:275380	12/46 (26%)
		leucine-rich repeat	266..289	CDD:275380	10/22 (45%)
		leucine-rich repeat	290..313	CDD:275380	5/22 (23%)
		leucine-rich repeat	314..338	CDD:275380	9/23 (39%)
		LRR_8	337..397	CDD:404697	17/84 (20%)
		leucine-rich repeat	339..360	CDD:275380	9/45 (20%)
lrrn1-like	NP_001106456.1	NEL	<52..>262	CDD:330839	70/237 (30%)
		leucine-rich repeat	60..79	CDD:275380	5/19 (26%)
		leucine-rich repeat	80..102	CDD:275380	5/21 (24%)
		LRR_8	101..161	CDD:316378	23/62 (37%)
		leucine-rich repeat	103..126	CDD:275380	11/25 (44%)
		leucine-rich repeat	127..150	CDD:275380	8/22 (36%)
		leucine-rich repeat	151..174	CDD:275380	8/22 (36%)
		leucine-rich repeat	175..198	CDD:275380	5/22 (23%)
		leucine-rich repeat	199..222	CDD:275380	11/46 (24%)
		leucine-rich repeat	223..246	CDD:275380	7/22 (32%)
		leucine-rich repeat	247..294	CDD:275380	15/46 (33%)
		LRR_8	294..356	CDD:316378	17/61 (28%)
		leucine-rich repeat	295..319	CDD:275380	9/23 (39%)
		leucine-rich repeat	320..345	CDD:275380	7/24 (29%)
		leucine-rich repeat	346..367	CDD:275380	3/20 (15%)
		PCC	351..>412	CDD:188093	14/61 (23%)
		leucine-rich repeat	370..382	CDD:275378	7/34 (21%)
		Ig	448..515	CDD:319273
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	143	1.000	Inparanoid score	I4363
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm14097
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.960