DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fili and lingo1

DIOPT Version :9

Sequence 1:	NP_001369108.1	Gene:	Fili / 5740472	FlyBaseID:	FBgn0085397	Length:	789	Species:	Drosophila melanogaster
Sequence 2:	NP_001093719.1	Gene:	lingo1 / 100101739	XenbaseID:	XB-GENE-921957	Length:	606	Species:	Xenopus tropicalis

Alignment Length:	464	Identity:	134/464 - (28%)
Similarity:	208/464 - (44%)	Gaps:	73/464 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 LCGAIPVLLLLLLTLVILPPETTAFCPSKCQCLGGEANSRALCVDAALEDVPIQLNPETKYINLT 81
            ||   |:||:::.:::   ..:.:.||.:|.|  ...:...||......|||..:..:|:.::|:
Frog     9 LC---PILLIVVGSIL---SGSASGCPQRCDC--SPQDRSVLCHRKRYLDVPEGIPTDTRLLDLS 65

  Fly    82 VNRIRTL---EFS-LPFYMKLEILDLSQNIIETLGSKNFEYQSELRTLNLSRNLVSSLHKHAFKG 142
            .|||:.|   ||| .|:   ||.|:|::||:..:....|.....||:|.|..|.:..:....|.|
Frog    66 KNRIKALNQDEFSAFPY---LEELELNENIVSIIEPGAFNGLFNLRSLGLRSNRLKLIPLGVFTG 127

  Fly   143 LTNLLLLDLSFNRIETVHPTALSDLASLVELDLTNNNIVSLEDNCFKGMNTLEVLVFRNNRLLDV 207
            |:||..||:|.|:|..:......||.:|..|::.:|::|.:....|:|:|:||.|......|..|
Frog   128 LSNLTQLDISENKIVILLDDMFQDLYNLKSLEVGDNDLVYISHRAFRGLNSLEELTLEKCNLTSV 192

  Fly   208 PASNLWHLHALKSLDMSLNLVEFVRNDSFEGLKELLALSVQGNVMSELDLSAFEGLISLKHLDLS 272
            |...|.|||.|.:|.:....:..:|:.||:.|..|..|.:..  ...||.....||..|
Frog   193 PTEALSHLHGLITLKLRYLNINVIRDYSFKRLYRLKNLEIAH--WPYLDTMTSNGLYGL------ 249

  Fly   273 DNNLTMVPTQQLSKLSNLTYLNLGGNRFSQLPAVAFLNLFHLRELHLSRLDFLQRIDSRAFVDNT 337
                            |||.|::..:..|.:|.||..:|.:||.|:|| .:.:..::.....:..
Frog   250 ----------------NLTSLSITHSNLSSIPYVAIRHLVYLRFLNLS-YNPITAVEGSMLYELL 297

  Fly   338 HLQTLHLNNNPQLSDIPMRLFQGNPNILEVYMQSNSLQTLYSAQF-PVDQLQKLYLGDNPLQCNC 401
            .||..||... |||.:....|:|..::..:.:.||.|.||..:.| .|..|:.|.|..|||.|:|
Frog   298 RLQEFHLVGG-QLSVVEPYAFRGLNHLKVLNVSSNYLSTLEESSFHSVGNLETLILDKNPLACDC 361

  Fly   402 SLLWL----WRLVTGNFEGVDPGM---EHAAGGAVAALAKEADD--------------EELADEA 445
            .|||:    |||   ||....|..   |:..|       ||..|              ..:.|.:
Frog   362 RLLWIFRRRWRL---NFSRQQPSCSSPEYVQG-------KEFKDFPDVLQPNYFTCRRARIQDHS 416

  Fly   446 TAVASTDDG 454
            ..|...|:|
Frog   417 AQVVYVDEG 425

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fili	NP_001369108.1	leucine-rich repeat	75..97	CDD:275378	10/25 (40%)
		leucine-rich repeat	98..121	CDD:275380	7/22 (32%)
		LRR_8	120..180	CDD:404697	20/59 (34%)
		leucine-rich repeat	122..145	CDD:275380	8/22 (36%)
		leucine-rich repeat	146..169	CDD:275380	8/22 (36%)
		LRR	<161..>354	CDD:227223	53/192 (28%)
		leucine-rich repeat	170..193	CDD:275380	6/22 (27%)
		leucine-rich repeat	194..217	CDD:275380	9/22 (41%)
		leucine-rich repeat	218..265	CDD:275380	12/46 (26%)
		leucine-rich repeat	266..289	CDD:275380	1/22 (5%)
		leucine-rich repeat	290..313	CDD:275380	8/22 (36%)
		leucine-rich repeat	314..338	CDD:275380	5/23 (22%)
		LRR_8	337..397	CDD:404697	20/60 (33%)
		leucine-rich repeat	339..360	CDD:275380	8/20 (40%)
lingo1	NP_001093719.1	LRRNT	27..61	CDD:214470	10/35 (29%)
		LRR 1	58..79		8/20 (40%)
		leucine-rich repeat	59..82	CDD:275380	9/22 (41%)
		PLN00113	62..>381	CDD:215061	109/350 (31%)
		LRR 2	82..103		7/23 (30%)
		leucine-rich repeat	83..106	CDD:275380	7/22 (32%)
		LRR_8	106..165	CDD:338972	20/58 (34%)
		LRR 3	106..127		6/20 (30%)
		leucine-rich repeat	107..130	CDD:275380	8/22 (36%)
		LRR 4	130..151		7/20 (35%)
		leucine-rich repeat	131..154	CDD:275380	8/22 (36%)
		LRR 5	154..175		5/20 (25%)
		leucine-rich repeat	155..178	CDD:275380	6/22 (27%)
		LRR 6	178..199		7/20 (35%)
		leucine-rich repeat	179..250	CDD:275380	23/94 (24%)
		LRR 7	202..223		5/20 (25%)
		leucine-rich repeat	203..226	CDD:275380	6/22 (27%)
		LRR 8	250..271		8/20 (40%)
		leucine-rich repeat	251..274	CDD:275380	8/22 (36%)
		LRR 9	274..295		5/21 (24%)
		leucine-rich repeat	275..298	CDD:275380	5/23 (22%)
		LRR 10	298..319		8/21 (38%)
		leucine-rich repeat	299..322	CDD:275380	9/23 (39%)
		LRR 11	322..343		6/20 (30%)
		leucine-rich repeat	323..343	CDD:275380	6/19 (32%)
		Ig	425..500	CDD:386229	1/1 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm9420
Panther	1	1.100	-	-	O	PTHR24373
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.010