DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fili and lingo4a

DIOPT Version :9

Sequence 1:	NP_001369108.1	Gene:	Fili / 5740472	FlyBaseID:	FBgn0085397	Length:	789	Species:	Drosophila melanogaster
Sequence 2:	NP_001076447.1	Gene:	lingo4a / 100005227	ZFINID:	ZDB-GENE-060503-275	Length:	618	Species:	Danio rerio

Alignment Length:	382	Identity:	116/382 - (30%)
Similarity:	176/382 - (46%)	Gaps:	48/382 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 TTAFCPSKCQCLGGEANSRAL----CVDAALEDVPIQLNPETKYINLTVNRIRTLE----FSLPF 94
            |:..|..:|.|      |..|    |....|..||..:...|:.:|||.|.::||.    |||
Zfish    38 TSGPCAQRCDC------SPKLPLVDCSSQQLSAVPEGVPDATQVLNLTYNHLKTLSSRQFFSL-- 94

  Fly    95 YMKLEILDLSQNIIETLGSKNFEYQSELRTLNLSRNLVSSLHKHAFKGLTNLLLLDLSFNRIETV 159
             .:|..||||.|::..:..:.|.....|.||.||||.:..:...||.||.|:..||:|.|.|..:
Zfish    95 -RQLRELDLSANMLTVIEVEAFVGLQNLITLRLSRNRLKIIPVGAFSGLPNVQFLDISENEILVL 158

  Fly   160 HPTALSDLASLVELDLTNNNIVSLEDNCFKGM-NTLEVLVFRNNRLLDVPASNLWHLHALKSLDM 223
            ......::.||.:|:.:.|::|.:.:..|.|: |.||:.:.|.| |..||:.....|..|:.|..
Zfish   159 LDDMFGEMPSLQKLEASENDLVFISNRAFSGLPNLLELRLERCN-LTTVPSEAFSRLTGLQHLRF 222

  Fly   224 SLNLVEFVRNDSFEGLKELLALSV-QGNVMSELDLSAFEGLISLKHLDLSDNNLTMVPTQQLSKL 287
            ....:..:.|:||..|:.|..|.| :...:..|.:::..|| :|..|.||..||:.||...|..|
Zfish   223 CRLGLTALPNNSFRQLQRLQDLHVSRCPWLHTLAVNSLIGL-NLTSLTLSHCNLSAVPYAPLHHL 286

  Fly   288 SNLTYLNLGGNRFSQLPAVAFLNLFHLRELHLSRLDFLQRIDSRAFVDNTHLQTLHLNNNPQLSD 352
            ..|.||:|..|..:.:.:....:|..|:||||.....| .::|.||.:....:.|::::
Zfish   287 VYLRYLDLSYNPITTVLSGLLGDLLRLQELHLVSTGLL-HVESGAFRNLAFFRLLNVSD------ 344

  Fly   353 IPMRLFQGNPNILEVYMQSNSLQTLYSAQF-PVDQLQKLYLGDNPLQCNCSLLWLWR 408
                               |.|.||..:.| .|..|:.|.|..|||.|:|.|||:.|
Zfish   345 -------------------NRLVTLEESAFHAVGSLEVLRLDGNPLACDCRLLWVMR 382

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fili	NP_001369108.1	leucine-rich repeat	75..97	CDD:275378	10/25 (40%)
		leucine-rich repeat	98..121	CDD:275380	7/22 (32%)
		LRR_8	120..180	CDD:404697	21/59 (36%)
		leucine-rich repeat	122..145	CDD:275380	11/22 (50%)
		leucine-rich repeat	146..169	CDD:275380	5/22 (23%)
		LRR	<161..>354	CDD:227223	54/194 (28%)
		leucine-rich repeat	170..193	CDD:275380	6/23 (26%)
		leucine-rich repeat	194..217	CDD:275380	8/22 (36%)
		leucine-rich repeat	218..265	CDD:275380	12/47 (26%)
		leucine-rich repeat	266..289	CDD:275380	10/22 (45%)
		leucine-rich repeat	290..313	CDD:275380	6/22 (27%)
		leucine-rich repeat	314..338	CDD:275380	9/23 (39%)
		LRR_8	337..397	CDD:404697	11/60 (18%)
		leucine-rich repeat	339..360	CDD:275380	1/20 (5%)
lingo4a	NP_001076447.1	LRRNT	41..70	CDD:214470	9/34 (26%)
		leucine-rich repeat	52..72	CDD:275380	5/19 (26%)
		leucine-rich repeat	73..96	CDD:275380	10/25 (40%)
		LRR_RI	88..380	CDD:238064	97/322 (30%)
		LRR_8	95..155	CDD:290566	23/59 (39%)
		leucine-rich repeat	97..120	CDD:275380	7/22 (32%)
		leucine-rich repeat	121..144	CDD:275380	11/22 (50%)
		leucine-rich repeat	145..168	CDD:275380	5/22 (23%)
		leucine-rich repeat	169..192	CDD:275380	6/22 (27%)
		LRR_8	191..250	CDD:290566	18/59 (31%)
		leucine-rich repeat	193..216	CDD:275380	8/23 (35%)
		leucine-rich repeat	217..240	CDD:275380	6/22 (27%)
		leucine-rich repeat	241..288	CDD:275380	16/47 (34%)
		LRR_8	264..323	CDD:290566	21/58 (36%)
		leucine-rich repeat	289..310	CDD:275380	5/20 (25%)
		LRR_8	312..371	CDD:290566	20/84 (24%)
		leucine-rich repeat	313..336	CDD:275380	9/23 (39%)
		leucine-rich repeat	337..356	CDD:275380	5/43 (12%)
		I-set	428..512	CDD:254352
		Ig	439..512	CDD:299845
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm6470
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24373
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	4.010