DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rgk3 and CG42541

DIOPT Version :9

Sequence 1:	NP_001286670.1	Gene:	Rgk3 / 5740446	FlyBaseID:	FBgn0085426	Length:	486	Species:	Drosophila melanogaster
Sequence 2:	NP_996345.3	Gene:	CG42541 / 31344	FlyBaseID:	FBgn0260658	Length:	1418	Species:	Drosophila melanogaster

Alignment Length:	518	Identity:	149/518 - (28%)
Similarity:	220/518 - (42%)	Gaps:	129/518 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 ISPMHHRMQKKTRSASICATGASIETVIHGMPGASGSATPEGGTP-------------GYRRRRP 56
            :||.:..:  .:.::.:.|||.:.:..|.|..|..|..   ||.|             |:.....
  Fly   753 VSPQYGTV--GSLNSQVPATGEAGKPGIVGSDGIGGGG---GGLPGGSSHNLNLTVGLGFLGGSS 812

  Fly    57 ATRSQSARITSG----------------ARSVRQKTKAQ----QQQQQQQHT-----------LQ 90
            .|.:..|.:|||                ..|.:||.:.|    |.||:|||.           :.
  Fly   813 TTLAAVAEVTSGPDGNGDSTDSPSPVSMIPSNQQKQQQQLLQLQLQQEQQHLPTHLPMKRERGVG 877

  Fly    91 ETRSYCTSEPRLSETE-------------TPPQRRKLS-----QRRPQTHAHRKSNAFLDVPTMN 137
            |:....||...::|..             |..||.:.|     .|||:....|:|
  Fly   878 ESSGASTSGTAIAELASSVVLATQSGKPMTERQRLRTSSMPAESRRPRLAEMRRS---------- 932

  Fly   138 MHHLRVNDDDEDVDRLRTFSASKGGIINRGDSFRRRRSRS-NSLAPSS------PMHTRNGVGGL 195
              .:...|.|....|||:||.:..||.|.|||.|.||||| ||:..:.      ..|..|..|..
  Fly   933 --AIHAGDPDMTYYRLRSFSITSHGICNLGDSLRSRRSRSINSVTSTGTSNSGVDRHNSNASGAS 995

  Fly   196 GGVAGGGSSLGLGCGYNGGSSSNGFGNANAQENHQPVEFYRVEMLGSAGVGKQALLSQFRTSDCI 260
            |.|..|..:                           |..|::.|||::||||..|..||.|||.|
  Fly   996 GEVIDGDPN---------------------------VPAYKIAMLGASGVGKTTLTYQFTTSDYI 1033

  Fly   261 NAYDGPECDD-AEQNVSIILNGTESELKFLTGNPESKDELE------QADAFLVVYSCIDKESFT 318
            .|||....|| .::.||::::..|::|:.: .:|..:...|      ..|.|:||||.||:.:|.
  Fly  1034 CAYDLSLDDDYGQKTVSVLVDNIETDLEII-DHPACEMSTEAFCATYNIDLFVVVYSVIDRNTFA 1097

  Fly   319 RAKQILSRLQDMDLLRHRPTILVANKIDLARSRAVSAQDGKCVACTFGAKFIEVSVGINHNCDEL 383
            .|:::|..|::.::|..|..||||||.||.|.|.|:.|.|:.||.....||||.|.|::||.|||
  Fly  1098 AAERVLQYLKENEMLLSRGAILVANKTDLQRHRVVTRQMGRKVAKEIACKFIETSSGLDHNVDEL 1162

  Fly   384 LAGTLTQIRLKKDQVQL-------QLNPKKSKDKDKNKFKENTNIETVETDNCLTDLKADDGG 439
            |.|.:.|::|...:::|       :||.:.:..|.:....: |.....:...|..|.:..|||
  Fly  1163 LVGIVAQVKLNPQRLRLLTELELQRLNLQSTIQKHRGMHLQ-TRRMVRQMSVCQGDEEIFDGG 1224

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rgk3	NP_001286670.1	P-loop_NTPase	235..>396	CDD:422963	70/167 (42%)
CG42541	NP_996345.3	RGK	1008..>1175	CDD:206715	70/167 (42%)
CG42541	NP_996345.3	small_GTPase	1008..1171	CDD:197466	69/163 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	98	1.000	Domainoid score	I4492
eggNOG	1	0.900	-	-		E2759_KOG0395
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D301527at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8675
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR45775
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.920