Protein Alignment Rgk3 and GEM

DIOPT Version :10

• Sequence 1: NP_001286670.1
• Gene: Rgk3 / 5740446
• FlyBaseID: FBgn0085426
• Length: 486
• Species: Drosophila melanogaster
• Sequence 2: NP_005252.1
• Gene: GEM / 2669
• HGNCID: 4234
• Length: 296
• Species: Homo sapiens
• Alignment Length: 435
• Identity: 104/435 - (23%)
• Similarity: 149/435 - (34%)
• Gaps: 164/435 - (37%)

  Fly    71 SVRQKTKAQQQQQQQQHTLQETRSYCTSEPRLSETETPPQRRKLS-QRRPQTHAHRKSNAFLDVP 134
            ::||.|...|.|||:                   ...|...|.|. |:.|..::||
Human     7 TMRQGTVGMQPQQQR-------------------WSIPADGRHLMVQKEPHQYSHR--------- 43

  Fly   135 TMNMHHLRVNDDDEDVDRLRTFSASKGGIINRGDSFRRRRSRSNSLAPSSPMHTRNGVGGLGGVA 199
              |.|.....|                         ..|||.|:....|
Human    44 --NRHSATPED-------------------------HCRRSWSSDSTDS---------------- 65

  Fly   200 GGGSSLGLGCGYNGGSSSNGFGNANAQENHQPVEFYRVEMLGSAGVGKQALLSQF------RTSD 258
                           ..|:..||.          :|||.::|..||||..|.:.|      ..||
Human    66 ---------------VISSESGNT----------YYRVVLIGEQGVGKSTLANIFAGVHDSMDSD 105

  Fly   259 C----INAYDGPECDDAEQNVSIILNGTESELKFLTGNPESKDE--LEQADAFLVVYSCIDKESF 317
            |    .:.|:.....|.|....|:|:..|::     |..|...:  ::..||:|:|||..|:.||
Human   106 CEVLGEDTYERTLMVDGESATIILLDMWENK-----GENEWLHDHCMQVGDAYLIVYSITDRASF 165

  Fly   318 TRAKQILSRLQDMDLLRHRPTILVANKIDLARSRAVSAQDGKCVACTFGAKFIEVSVGINHNCDE 382
            .:|.::..:|:........|.|||.||.||.|.|.||..:|:..|..|..||||.|..:.||..|
Human   166 EKASELRIQLRRARQTEDIPIILVGNKSDLVRCREVSVSEGRACAVVFDCKFIETSAAVQHNVKE 230

  Fly   383 LLAGTLTQIRLKKDQVQLQLNPKKSKDKDKNKFKENTNIETVETDNCLTDLKADDGGPRDANSPA 447
            |..|.:.|:||::|          ||:|::.:               |...|..:..||
Human   231 LFEGIVRQVRLRRD----------SKEKNERR---------------LAYQKRKESMPR------ 264

  Fly   448 HWYKSRSVMLASMKARQMLTWILGKEDS------KFKHCENLQVL 486
                         |||:....|:.|.:.      |.|.|.:|.||
Human   265 -------------KARRFWGKIVAKNNKNMAFKLKSKSCHDLSVL 296

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rgk3	NP_001286670.1	P-loop containing Nucleoside Triphosphate Hydrolases	235..>396	CDD:476819	60/172 (35%)
GEM	NP_005252.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..20		5/12 (42%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	37..68		11/97 (11%)
		RGK	76..296	CDD:206715	77/268 (29%)
		Calmodulin-binding. /evidence=ECO:0000250	266..285		4/18 (22%)