Protein Alignment Snoo and Skor2

DIOPT Version :10

• Sequence 1: NP_609164.3
• Gene: Snoo / 5740414
• FlyBaseID: FBgn0085450
• Length: 1223
• Species: Drosophila melanogaster
• Sequence 2: XP_038953261.1
• Gene: Skor2 / 681200
• RGDID: 1598071
• Length: 1008
• Species: Rattus norvegicus
• Alignment Length: 1271
• Identity: 253/1271 - (19%)
• Similarity: 374/1271 - (29%)
• Gaps: 486/1271 - (38%)

  Fly    72 PEPQDLHHHECSTRGTPPQIYSPATPPRELSQPILSVADAGCGELYETKLEGKTIGCFSVGGEMR 136
            |.|.|:      ...:|    |.|..|..||||....|:....::.:..|.|..|....:.|:.|
  Rat     7 PGPNDI------LLASP----SSAFQPDALSQPRPGHANLKPNQVGQVILYGIPIVSLVIDGQER 61

  Fly   137 LCLPQFLNNVLNDFSLEQINRIFDELGIYCSQCTHDQLVEFKAAKILPSDVKASGLITRTDAERL 201
            |||.|..|.:|.:||..:|:.....|||.|.|||..||...:.|..:|...:..|:||:.:||||
  Rat    62 LCLAQISNTLLKNFSYNEIHNRRVALGITCVQCTPVQLEILRRAGAMPISSRRCGMITKREAERL 126

  Fly   202 CAALLHRSDRNSYVPIESLAKGALSFHVYHKCFGKCEGICTPDMYSYQKPTCIKCLECDGWFSPQ 266
            |.:.| ..:|...:|      ...:|.|.|:|...|.|...|..|:..:..||||..|:.:|||.
  Rat   127 CKSFL-GENRPPKLP------DNFAFDVSHECAWGCRGSFIPARYNSSRAKCIKCSYCNMYFSPN 184

  Fly   267 KFVGHVHRKFE-NHTCHWGFDSRNWHDYLHVALDVENREKYQIILDQLK----------EVELKE 320
            ||:.|.||..: .:|.....:..:|..:|.:. |...:::.....:.:|          .:....
  Rat   185 KFIFHSHRTPDAKYTQPDAANFNSWRRHLKLT-DKSPQDELVFAWEDVKAMFNGGSRKRALPQPS 248

  Fly   321 MHKAQRELEHKKRKAEMLMDDGMLGSGPVLGLAGHPHGLVGALAPPPPPP------------MKQ 373
            .|.|...|...| .|.:.....:.|.|.:||    || |:||..||||||            .|:
  Rat   249 AHPACHPLSSVK-AAAVAAAAAVAGGGGLLG----PH-LLGAPPPPPPPPPLAELAGAPHAHHKR 307

  Fly   374 PQMDIPSGKKQLQQLKGATVAA---SALEYQYQVMYA-------------HCVQKEREREREHLP 422
            |:.|......|    :.|.|||   ||......|..|             .||
  Rat   308 PRFDDDDDSLQ----EAAVVAAASLSAAAASLSVAAATGGAGPGAGGPGGGCV------------ 356

  Fly   423 HSHPLPRQHRAVLVATT-------------PYPHLPQYPTPPTLNSSSAFRPWGPDTTKAFLHAY 474
                     ..|.|..|             .||.:|    .|:..|........|.....|.|.|
  Rat   357 ---------AGVGVGATAGAGAAAGTKGPRSYPVIP----VPSKGSFGGVLQKFPGCGGLFPHPY 408

  Fly   475 GATLSSLPYA-CQEPPELQNPERVVRSTDKRYA------------------ERTYQPNVALAPRK 520
            ....::..:. |.:..:.......:.......|                  :..|.|.....|.:
  Rat   409 TFPAAAAAFGLCHKKEDAGTAAEALGGAGAGSAGAAPKAGLSGLFWPAGRKDAFYPPFCMFWPPR 473

  Fly   521 SILSKERDKDRERMEREVMERQRLREKETDHQVVHIKQERSQTPTP----PTASPPD--GVVLP- 578
            :                                      ....|.|    |...||.  |..|.
  Rat   474 T--------------------------------------PGGLPVPTYLQPPPQPPSALGCALGD 500

  Fly   579 ---------LDVVEPPHPSSSGSNSPLPAHLPA----APATAPPNAGG---------APP----- 616
                     ||:.||.....|...:|.|...|.    .|.:.||..||         :||
  Rat   501 SPALLRQAFLDLAEPGGAGGSAEAAPPPGQPPPVVANGPGSGPPATGGTGSRDTLFESPPGGSGG 565

  Fly   617 ------TPTNLRNMRSPEEFSAGGSNEI-TSSTSPHHQQ----------SSHH-QVVQPTAGAPP 663
                  ||.....:.|....::.|:..: |...:|||..          |.|| ...:|..|.
  Rat   566 DCSAGSTPPAEPGVTSGNGATSSGAGSVGTRVPAPHHPHLLEGRKAGGGSYHHSSAFRPVGGK-- 628

  Fly   664 PSQHIIATVNQHAKLLPSSSSLPNGNGSSSLAATNNEPSRIRINKNLMSQQPVVAVSGMTPHHHQ 728
                            ..|.||...:|:|: .|.::.|:.                    .|||.
  Rat   629 ----------------DDSESLAKLHGASA-GAPHSAPAH--------------------HHHHH 656

  Fly   729 HHPTHMHHFSHGYYKSQASSPTQSSSAGLNLSTHSSNVVSSPHHAT----------QPKTHHSSV 783
            |||.|.||           .|.|..|..|.|........|..||..          .|:.||..:
  Rat   657 HHPHHHHH-----------HPPQPPSPLLLLQPQPDEPGSERHHPAPPPPPPPPPLAPQPHHRGL 710

  Fly   784 GSGNHGLQNGKPHLGSEFELSTDTDDTDSLNGEPDSSAMLPPWEQAVESLRETRPKDRERVLLIL 848
            .|                               |:.::...|.|.:.|.
  Rat   711 LS-------------------------------PEGTSCSYPSEDSSED---------------- 728

  Fly   849 QRLLQENDQYRYNNIQLSELLHKQDAHIADLTEQLQRYRRQFEEQVCKVDLRKMPFKHQTRLENV 913
                :|:::                                 |||...|:..| |.:
  Rat   729 ----EEDEE---------------------------------EEQEVDVEGHK-PLE-------- 747

  Fly   914 VEAGRGEAEED----EELEEDEMEDRA--------------------NNNNQQELSPLIKAPANG 954
                 ||.|||    |:.||:|.|.|.                    ..:.:...:|.:.|....
  Rat   748 -----GEEEEDGRDPEDEEEEEEETRVLLGDSLVGGGRFLQGRGLSEKGSGRDRTTPAVGAFPLA 807

  Fly   955 LRRS--------VTPPNCCASEGGDCEKPDEPESKRIKLQVGEKAEDKQVENEESPSNGTESHDL 1011
            |..|        :..|.     |.|...|..|.....|...|         ....|.:......|
  Rat   808 LNSSRLLQEDGKLGDPG-----GSDLPAPPPPSLAPQKASGG---------GGSRPGSPVHHPSL 858

  Fly  1012 EKLEKNDDKTDPTNNPKSPQPSQISSDDEMEEDDEDEDEEDEDEEVQVEAPHSSALATPPTATTP 1076
            |:.....|...|..|            :::....:|::..|:::|      ||..:.
  Rat   859 EEEPSYKDNQKPKEN------------NQVILSAKDDNFSDKNKE------HSFFIT-------- 897

  Fly  1077 LSPDSAATAGQLFDSSNSSD----ESSMKKAQMSACHALEKMSSNVGSDENNQRLAEESQEDEAE 1137
                         ||.:|.|    .|.....:.::.|:|:|...|:|.:|..:.|.|
  Rat   898 -------------DSDSSGDFWRERSGEHTQETNSPHSLKKDVENMGKEELQKVLFE-------- 941

  Fly  1138 EDPEEEDSDDDEMPLQQRQQQQRQRVAPQNVLSGPS 1173
                       ::.|::|.:|:.|      ||.|.|
  Rat   942 -----------QIDLRRRLEQEFQ------VLKGNS 960

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Snoo	NP_609164.3	DHD_Ski_Sno	116..206	CDD:410782	33/89 (37%)
		c-SKI_SMAD_bind	226..317	CDD:198114	26/101 (26%)
		AF-4	637..>789	CDD:461550	37/173 (21%)
Skor2	XP_038953261.1	DHD_Skor	41..131	CDD:410783	33/89 (37%)
		c-SKI_SMAD_bind	144..236	CDD:198114	26/92 (28%)