DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Snoo and Skor2

DIOPT Version :9

Sequence 1:	NP_001097115.1	Gene:	Snoo / 5740414	FlyBaseID:	FBgn0085450	Length:	1223	Species:	Drosophila melanogaster
Sequence 2:	NP_001103213.1	Gene:	Skor2 / 664805	MGIID:	3645984	Length:	1008	Species:	Mus musculus

Alignment Length:	1323	Identity:	273/1323 - (20%)
Similarity:	389/1323 - (29%)	Gaps:	523/1323 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly    72 PEPQDLHHHECSTRGTPPQIYSPATPPRELSQPILSVADAGCGELYETKLEGKTIGCFSVGGEMR 136
            |.|.|:      ...:|    |.|..|..||||....|:....::.:..|.|..|....:.|:.|
Mouse     7 PGPNDI------LLASP----SSAFQPDALSQPRPGHANLKPNQVGQVILYGIPIVSLVIDGQER 61

  Fly   137 LCLPQFLNNVLNDFSLEQINRIFDELGIYCSQCTHDQLVEFKAAKILPSDVKASGLITRTDAERL 201
            |||.|..|.:|.:||..:|:.....|||.|.|||..||...:.|..:|...:..|:||:.:||||
Mouse    62 LCLAQISNTLLKNFSYNEIHNRRVALGITCVQCTPVQLEILRRAGAMPISSRRCGMITKREAERL 126

  Fly   202 CAALLHRSDRNSYVPIESLAKGALSFHVYHKCFGKCEGICTPDMYSYQKPTCIKCLECDGWFSPQ 266
            |.:.| ..:|...:|      ...:|.|.|:|...|.|...|..|:..:..||||..|:.:|||.
Mouse   127 CKSFL-GENRPPKLP------DNFAFDVSHECAWGCRGSFIPARYNSSRAKCIKCSYCNMYFSPN 184

  Fly   267 KFVGHVHRKFE-NHTCHWGFDSRNWHDYLHVALDVENREKYQIILDQLK----------EVELKE 320
            ||:.|.||..: .:|.....:..:|..:|.:. |...:::.....:.:|          .:....
Mouse   185 KFIFHSHRTPDAKYTQPDAANFNSWRRHLKLT-DKSPQDELVFAWEDVKAMFNGGSRKRALPQPS 248

  Fly   321 MHKAQRELEHKKRKAEMLMDDGMLGSGPVLGLAGHPHGLVGALAPPPPPP------------MKQ 373
            .|.|...|...| .|.:.....:.|.|.:||    || |:||..||||||            .|:
Mouse   249 AHPACHPLSSVK-AAAVAAAAAVAGGGGLLG----PH-LLGAPPPPPPPPPLAELAGAPHAHHKR 307

  Fly   374 PQMDIPSGKKQLQQLKGATVAA---SALEYQYQVMYA-------------HCVQKEREREREHLP 422
            |:.|......|    :.|.|||   ||......|..|             .||.
Mouse   308 PRFDDDDDSLQ----EAAVVAAASLSAAAASLSVAAATGGAGPGAGGPGGGCVA----------- 357

  Fly   423 HSHPLPRQHRAVLVATTPYPHLPQYPTPPTLNSSS------AFRPWG-----PDTTKAFLHAYG- 475
             ...:.....|...|.|..|.  .||..|..:..|      .|...|     |.|..|...|:|
Mouse   358 -GVGVGASAGAGAAAGTKGPR--SYPVIPVPSKGSFGGVLQKFPGCGGLFPHPYTFPAAAAAFGL 419

  Fly   476 ---------------------------ATLSSL------------PYACQEPPELQNPERVVRST 501
                                       |.||.|            |:....||.          |
Mouse   420 CHKKEDAGTAAEALGGAGAGSAGAAPKAGLSGLFWPAGRKDAFYPPFCMFWPPR----------T 474

  Fly   502 DKRYAERTY-QPNVALAPRKSILSKERDKDRERMEREVMERQRLREKETDHQVVHIKQERSQTPT 565
            .......|| ||                                                  .|.
Mouse   475 PGGLPVPTYLQP--------------------------------------------------PPQ 489

  Fly   566 PPTASPPDGVVLP----------LDVVEPPHPSSSGSNSPLPAHLPA----APATAPPNAGG--- 613
            ||:|.   |..|.          ||:.||.....|...:|.|...|.    .|.:.||..||
Mouse   490 PPSAL---GCALGDSPALLRQAFLDLAEPGGAGGSAEAAPPPGQPPPVVANGPGSGPPATGGTGA 551

  Fly   614 ------APP-----------TPTNLRNMRSPEEFSAGGSNEI-TSSTSPHHQQ----------SS 650
                  :||           ||...:.:.|....::.|:..: |...:|||..          |.
Mouse   552 RDTLFESPPGGSGGDCSAGSTPPAEQGVTSGTGSASSGAGSVGTRVPAPHHPHLLEGRKAGGGSY 616

  Fly   651 HHQVVQPTAGAPPPSQHIIATVNQHAKLLPSSSSLPNGNGSSSLAATNNEPSRIRINKNLMSQQP 715
            ||.......|....::.:       |||..:|:..|           ::.|:.
Mouse   617 HHSSAFRPVGGKDDAESL-------AKLHGASAGTP-----------HSAPAH------------ 651

  Fly   716 VVAVSGMTPHHHQHHPTHMHHFSHGYYKSQASSPTQSSSAGLNLSTHSSNVVSSPHHAT------ 774
                    .|||.|||.|.||           .|.|..|..|.|........|..||..
Mouse   652 --------HHHHHHHPHHHHH-----------HPPQPPSPLLLLQPQPDEPGSERHHPAPPPPPP 697

  Fly   775 ----QPKTHHSSVGSGNHGLQNGKPHLGSEFELSTDTDDTDSLNGEPDSSAMLPPWEQAVESLRE 835
                .|:.||..:.|                               |:.::...|.|.:.|.
Mouse   698 PPPLAPQPHHRGLLS-------------------------------PEGTSCSYPSEDSSED--- 728

  Fly   836 TRPKDRERVLLILQRLLQENDQYRYNNIQLSELLHKQDAHIADLTEQLQRYRRQFEEQVCKVDLR 900
                             :|:::                                 |||...|:..
Mouse   729 -----------------EEDEE---------------------------------EEQEVDVEGH 743

  Fly   901 KMPFKHQTRLENVVEAGRGEAEEDEELEEDEMEDRANNNNQQELSPLIKAPANGLRRSVTPPNCC 965
            | |.:             ||.|||....|||.|:      .:|...|:.....|..|.:....
Mouse   744 K-PLE-------------GEEEEDGRDPEDEEEE------DEETRVLLGDSLVGGGRFLQGRG-- 786

  Fly   966 ASEGGDCEKPDEP---------ESKRIKLQVGEKAEDKQVENEESPSNGTESHDLEKLEKNDDKT 1021
            .||.|.......|         .|.|: ||...|..|         |.|:            |..
Mouse   787 LSEKGSGRDRTTPAVGAFPLALNSSRL-LQEDGKLGD---------SGGS------------DLP 829

  Fly  1022 DPTNNPKSPQPSQISSDD---------EMEEDDEDEDEEDEDEEVQVEAPHSSALATPPTATTPL 1077
            .|...|.:||.:..|...         .:||:...:|.:...|..||            ..:|..
Mouse   830 APPPPPLAPQKASSSGGSRPGSPVHHPSLEEEPSYKDNQKPKENNQV------------IISTKD 882

  Fly  1078 SPDSAATAGQLF---DSSNSSD----ESSMKKAQMSACHALEKMSSNVGSDENNQRLAEESQEDE 1135
            ...|....|..|   ||.:|.|    .|.....:.::.|:|:|...|:|.:|..:.|.|
Mouse   883 DNFSDKNKGHGFFITDSDSSGDFWRERSGEHTQETNSPHSLKKDVENMGKEELQKVLFE------ 941

  Fly  1136 AEEDPEEEDSDDDEMPLQQRQQQQRQRVAPQNVLSGPSVAGHHPAPAHPPMATKASKKQTPPAPP 1200
                         ::.|::|.:|:.|      ||.|
Mouse   942 -------------QIDLRRRLEQEFQ------VLKG----------------------------- 958

  Fly  1201 TAAATTTASATTNCELQIKKEIA 1223
                .|:.....|.:.|:|:|:|
Mouse   959 ----NTSFPVFNNFQDQMKRELA 977

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Snoo	NP_001097115.1	Ski_Sno	114..207	CDD:280577	33/92 (36%)
Snoo	NP_001097115.1	c-SKI_SMAD_bind	226..317	CDD:198114	26/101 (26%)
Skor2	NP_001103213.1	Ski_Sno	39..132	CDD:367087	34/93 (37%)
		c-SKI_SMAD_bind	145..235	CDD:370119	26/90 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	280..315		13/35 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	514..927		112/601 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	185	1.000	Inparanoid score	I3926
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.960