DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Snoo and SKOR2

DIOPT Version :9

Sequence 1:	NP_001097115.1	Gene:	Snoo / 5740414	FlyBaseID:	FBgn0085450	Length:	1223	Species:	Drosophila melanogaster
Sequence 2:	NP_001264992.1	Gene:	SKOR2 / 652991	HGNCID:	32695	Length:	1015	Species:	Homo sapiens

Alignment Length:	1310	Identity:	268/1310 - (20%)
Similarity:	398/1310 - (30%)	Gaps:	490/1310 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    72 PEPQDLHHHECSTRGTPPQIYSPATPPRELSQPILSVADAGCGELYETKLEGKTIGCFSVGGEMR 136
            |.|.|:      ...:|...:.|.|    ||||....|:....::.:..|.|..|....:.|:.|
Human     7 PGPNDI------LLASPSSAFQPDT----LSQPRPGHANLKPNQVGQVILYGIPIVSLVIDGQER 61

  Fly   137 LCLPQFLNNVLNDFSLEQINRIFDELGIYCSQCTHDQLVEFKAAKILPSDVKASGLITRTDAERL 201
            |||.|..|.:|.:||..:|:.....|||.|.|||..||...:.|..:|...:..|:||:.:||||
Human    62 LCLAQISNTLLKNFSYNEIHNRRVALGITCVQCTPVQLEILRRAGAMPISSRRCGMITKREAERL 126

  Fly   202 CAALLHRSDRNSYVPIESLAKGALSFHVYHKCFGKCEGICTPDMYSYQKPTCIKCLECDGWFSPQ 266
            |.:.| ..:|...:|      ...:|.|.|:|...|.|...|..|:..:..||||..|:.:|||.
Human   127 CKSFL-GENRPPKLP------DNFAFDVSHECAWGCRGSFIPARYNSSRAKCIKCSYCNMYFSPN 184

  Fly   267 KFVGHVHRKFE-NHTCHWGFDSRNWHDYLHVALDVENREKYQIILDQLKEV--------ELKE-- 320
            ||:.|.||..: .:|.....:..:|..:|.:. |...:::.....:.:|.:        .|.:
Human   185 KFIFHSHRTPDAKYTQPDAANFNSWRRHLKLT-DKSPQDELVFAWEDVKAMFNGGSRKRALPQPG 248

  Fly   321 MHKAQRELEHKKRKAEMLMDDGMLGSGPVLGLAGHPHGLVGALAPPPPPP-------------MK 372
            .|.|...|...| .|.:.....:.|.|.:||    || |:||..||||||             .|
Human   249 AHPACHPLSSVK-AAAVAAAAAVAGGGGLLG----PH-LLGAPPPPPPPPPPLAELAGAPHAHHK 307

  Fly   373 QPQMDIPSGKKQLQQLKGATVAA---SALEYQYQVMYAH-------------CV----------- 410
            :|:.|......|    :.|.|||   ||......|..|.             ||
Human   308 RPRFDDDDDSLQ----EAAVVAAASLSAAAASLSVAAASGGAGTGGGGAGGGCVAGVGVGAGAGA 368

  Fly   411 -----QKEREREREHLPHSHPLPRQHRAVLVATTP------------------YPHLPQYPTPPT 452
                 .|.        |.|:|         |...|                  :||...:|.
Human   369 GAGAGAKG--------PRSYP---------VIPVPSKGSFGGVLQKFPGCGGLFPHPYTFPA--- 413

  Fly   453 LNSSSAFR-PWGPDTTKAFLHAYG------------ATLSSL------------PYACQEPPELQ 492
              :::||. ....:...|...|.|            |.||.|            |:....||  :
Human   414 --AAAAFSLCHKKEDAGAAAEALGGAGAGGAGAAPKAGLSGLFWPAGRKDAFYPPFCMFWPP--R 474

  Fly   493 NPERVVRSTDKRYAERTYQPNVALAPRKSILSKERDKDRERMEREVMERQRLREKETDHQVVHIK 557
            .|..:...|   |.:...||..||.....             |...:.||..
Human   475 TPGGLPVPT---YLQPPPQPPSALGCALG-------------ESPALLRQAF------------- 510

  Fly   558 QERSQTPTPPTASPPDGVVLPLDVVEPPHPSSSGSNSPLPAHLPAAPATAPPNAGGAPPTPTNLR 622
                                 ||:.||...:.|...:|.|...|...|..|   |..||.|....
Human   511 ---------------------LDLAEPGGAAGSAEAAPPPGQPPQVVANGP---GSGPPPPAGGA 551

  Fly   623 NMRSP--EEFSAGGSNEITSSTSPHHQQSSHHQVVQPTAGAPPPSQHIIATVNQHAKLLP----- 680
            ..|..  |....|...:.::.::|.....:........||:.|....:.|.  .|..||.
Human   552 GSRDALFESPPGGSGGDCSAGSTPPADSVAAAGAGAAAAGSGPAGSRVPAP--HHPHLLEGRKAG 614

  Fly   681 ------SSSSLPNG--NGSSSLA----ATNNEPSRIRINKNLMSQQPVVAVSGMTPHHHQHHPTH 733
                  ||:..|.|  :.:.|||    |:...|.                 |..|..||.|||.|
Human   615 GGSYHHSSAFRPVGGKDDAESLAKLHGASAGAPH-----------------SAQTHPHHHHHPHH 662

  Fly   734 MHHFSHGYYKSQASSPTQSSSAGLNLSTHSSNVVSSPHHATQP-------------KTHHSSVGS 785
            .||..|         |.|..|..|.|........|..||...|             ..||..:.|
Human   663 HHHHHH---------PPQPPSPLLLLPPQPDEPGSERHHPAPPPPPPPPPPPPLAQHPHHRGLLS 718

  Fly   786 GNHGLQNGKPHLGSEFELSTDTDDTDSLNGEPDSSAMLPPWEQAVESLRETRPKDRERVLLILQR 850
                                           |..::...|.|.:.|
Human   719 -------------------------------PGGTSCCYPSEDSSE------------------- 733

  Fly   851 LLQENDQYRYNNIQLSELLHKQDAHIADLTEQLQRYRRQFEEQVCKVDLRKMPFKHQTRLENVVE 915
              .|:|:.                                |||...|:..|.|
Human   734 --DEDDEE--------------------------------EEQEVDVEGHKPP------------ 752

  Fly   916 AGRGEAEEDEE---LEEDEMEDRANNNNQQELSPLIKAPANGLRRSVTPPNCCASEGGDCEKPDE 977
                |.||:||   .::||.||       :|...|:..|..|              ||
Human   753 ----EGEEEEEGRDPDDDEEED-------EETEVLLGDPLVG--------------GG------- 785

  Fly   978 PESKRIKLQVGEKAEDKQVENEESPS------NGTESHDLEKLEKNDDKTDPTNN-------PKS 1029
                  :...|....:|....:.:|:      .|..|..|  |:::....||.::       |.:
Human   786 ------RFLQGRGPSEKGSSRDRAPAVAGAFPLGLNSSRL--LQEDGKLGDPGSDLPPPPPPPLA 842

  Fly  1030 PQ---------PSQISSDDEMEEDD--EDEDEEDEDEEVQVEAPHSSALATPPTATTPLSPDSAA 1083
            ||         |........:||..  :|..:..|:.:|.|.....::.:......:....||.|
Human   843 PQKASGGGSSSPGSPVHHPSLEEQPSYKDSQKTKENNQVIVSTKDDNSFSDKNKEHSFFITDSDA 907

  Fly  1084 TAGQLFDSSNSSDESSMKKAQMSACHALEKMSSNVGSDENNQRLAEESQEDEAEEDPEEEDSDDD 1148
            :.|..:     .:.|.....:.::.|:|:|...|:|.:|..:.|.|
Human   908 SGGDFW-----RERSGEHTQETNSPHSLKKDVENMGKEELQKVLFE------------------- 948

  Fly  1149 EMPLQQRQQQQRQRVAPQNVLSGPSVAGHHPAPAHPPMATKASKKQTPPAPPTAAATTTASATTN 1213
            ::.|::|.:|:.|      ||.|                                 .|:.....|
Human   949 QIDLRRRLEQEFQ------VLKG---------------------------------NTSFPVFNN 974

  Fly  1214 CELQIKKEIA 1223
            .:.|:|:|:|
Human   975 FQDQMKRELA 984

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Snoo	NP_001097115.1	Ski_Sno	114..207	CDD:280577	33/92 (36%)
Snoo	NP_001097115.1	c-SKI_SMAD_bind	226..317	CDD:198114	26/99 (26%)
SKOR2	NP_001264992.1	Ski_Sno	39..132	CDD:280577	34/93 (37%)
SKOR2	NP_001264992.1	c-SKI_SMAD_bind	145..235	CDD:285935	26/90 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	191	1.000	Inparanoid score	I3874
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.960