DRSC/TRiP Functional Genomics Resources

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Protein Alignment Snoo and SKIL

DIOPT Version :10

Sequence 1:NP_609164.3 Gene:Snoo / 5740414 FlyBaseID:FBgn0085450 Length:1223 Species:Drosophila melanogaster
Sequence 2:NP_005405.2 Gene:SKIL / 6498 HGNCID:10897 Length:684 Species:Homo sapiens


Alignment Length:695 Identity:190/695 - (27%)
Similarity:282/695 - (40%) Gaps:184/695 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly    13 LKKYQTS------ATKSLQGPGHALTTAG---VLDIVTNGRS--------------------ESP 48
            ::..||:      :||.|.|.|...:...   :.||..||::                    |:.
Human     1 MENLQTNFSLVQGSTKKLNGMGDDGSPPAKKMITDIHANGKTINKVPTVKKEHLDDYGEAPVETD 65

  Fly    49 GLNGK--CQASPPVVAL---IKKEI----------LSSPEPQDLHHHECSTRGTPPQIYSPATPP 98
            |.:.|  |.:.|..:.|   :|..:          |..|......|   |.....|.::.|...|
Human    66 GEHVKRTCTSVPETLHLNPSLKHTLAQFHLSSQSSLGGPAAFSARH---SQESMSPTVFLPLPSP 127

  Fly    99 RELSQPILSVADAGCGELYETKLEGKTIGCFSVGGEMRLCLPQFLNNVLNDFSLEQINRIFDELG 163
            :.|..|:|..:|:.. ||.:|.|||::|.||.||||.||||||.||:||.:|:|:|||.:.|||.
Human   128 QVLPGPLLIPSDSST-ELTQTVLEGESISCFQVGGEKRLCLPQVLNSVLREFTLQQINTVCDELY 191

  Fly   164 IYCSQCTHDQLVEFKAAKILPSDVKASGLITRTDAERLCAALLHR---SDRNSYVPIES----LA 221
            ||||:||.|||...|...|||.:..:.||||.|||:|||.|||..   ....|.:|.:|    |.
Human   192 IYCSRCTSDQLHILKVLGILPFNAPSCGLITLTDAQRLCNALLRPRTFPQNGSVLPAKSSLAQLK 256

  Fly   222 KGALSFHVYHKCFGKCEGICTPDMYSYQKPTCIKCLECDGWFSPQKFVGHVHRKFENHTCHWGFD 286
            :...:|.|.|:|.|||:|:..|..|......||:||||.|.|:||.||.|.||..:..||||||:
Human   257 ETGSAFEVEHECLGKCQGLFAPQFYVQPDAPCIQCLECCGMFAPQTFVMHSHRSPDKRTCHWGFE 321

  Fly   287 SRNWHDYLHV---ALDVENREKYQIILDQLKE-------------------VELKEMHKA-QREL 328
            |..||.||||   .|.....:|.:|||:::||                   :||:..:.. ::|.
Human   322 SAKWHCYLHVNQKYLGTPEEKKLKIILEEMKEKFSMRSGKRNQSKTDAPSGMELQSWYPVIKQEG 386

  Fly   329 EHKKRKAEML-------MDDGMLGSGPVLGLA----------------------GHPHG-LVGAL 363
            :|..:....|       |.|.::.....|..|                      .|..| |...:
Human   387 DHVSQTHSFLHPSYYLYMCDKVVAPNVSLTSAVSQSKELTKTEASKSISRQSEKAHSSGKLQKTV 451

  Fly   364 APPPPPPMKQPQMDIPSGKKQLQQLK-----------------------------GATVAASALE 399
            :.|.....:|.:||:.:.::...:|.                             |...|||:..
Human   452 SYPDVSLEEQEKMDLKTSRELCSRLDASISNNSTSKRKSESATCNLVRDINKVGIGLVAAASSPL 516

  Fly   400 YQYQVMYAHCVQKEREREREHLPHSHPLPRQHRAVLVATTPYPHLPQYPTPPTLNSSSAFRPWGP 464
            ....|:   | :.::.:..|.:..:: |.:|.:..|:.                           
Human   517 LVKDVI---C-EDDKGKIMEEVMRTY-LKQQEKLNLIL--------------------------- 549

  Fly   465 DTTKAFLHAYGATLSSLPYACQEPPELQNPERVVRSTDKRYAERT---YQPNVALAPRKSILSK- 525
             ..|..|......|||.....:...|.||.::.:.|....:|:|.   |.....|..:...:.| 
Human   550 -QKKQQLQMEVKMLSSSKSMKELTEEQQNLQKELESLQNEHAQRMEEFYVEQKDLEKKLEQIMKQ 613

  Fly   526 --------ERDKDRERMEREVMERQRLREKETDHQVV--HIKQER 560
                    |:||:.|...:....||||...|.|.|.:  .::|||
Human   614 KCTCDSNLEKDKEAEYAGQLAELRQRLDHAEADRQELQDELRQER 658

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SnooNP_609164.3 DHD_Ski_Sno 116..206 CDD:410782 54/89 (61%)
c-SKI_SMAD_bind 226..317 CDD:198114 45/112 (40%)
AF-4 637..>789 CDD:461550
SKILNP_005405.2 DHD_Sno 137..236 CDD:410787 58/99 (59%)
c-SKI_SMAD_bind 261..356 CDD:198114 45/94 (48%)
SCP-1 355..>684 CDD:114219 55/337 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 420..454 3/33 (9%)
Smc <536..>684 CDD:440809 31/152 (20%)
Blue background indicates that the domain is not in the aligned region.

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