Protein Alignment Snoo and SKI

DIOPT Version :10

• Sequence 1: NP_609164.3
• Gene: Snoo / 5740414
• FlyBaseID: FBgn0085450
• Length: 1223
• Species: Drosophila melanogaster
• Sequence 2: XP_005244832.1
• Gene: SKI / 6497
• HGNCID: 10896
• Length: 730
• Species: Homo sapiens
• Alignment Length: 1018
• Identity: 246/1018 - (24%)
• Similarity: 363/1018 - (35%)
• Gaps: 363/1018 - (35%)

  Fly     7 PMISTVLKKYQTSATKSLQGPGHALTTAGVLDIVTNGRSESPGLNGKCQASPPVVALIKKEILSS 71
            |.:...|:::..|:..||.||. |.:.....:..   :.||....|......||.|        :
Human    15 PGLQKTLEQFHLSSMSSLGGPA-AFSARWAQEAY---KKESAKEAGAAAVPAPVPA--------A 67

  Fly    72 PEPQDLHHHECSTRGTPPQIYSPA--TPPRELSQPILSVADAGCGELYETKLEGKTIGCFSVGGE 134
            .||             ||.::.||  .||..|..|....:|... |..||.|||:||.||.||||
Human    68 TEP-------------PPVLHLPAIQPPPPVLPGPFFMPSDRST-ERCETVLEGETISCFVVGGE 118

  Fly   135 MRLCLPQFLNNVLNDFSLEQINRIFDELGIYCSQCTHDQLVEFKAAKILPSDVKASGLITRTDAE 199
            .||||||.||:||.||||:|||.:.|||.||||:||.|||...|...|||....:.||||:||||
Human   119 KRLCLPQILNSVLRDFSLQQINAVCDELHIYCSRCTADQLEILKVMGILPFSAPSCGLITKTDAE 183

  Fly   200 RLCAALLHRSDRNSYVP------IESLAKG----ALSFHVYHKCFGKCEGICTPDMYSYQKPTCI 254
            |||.|||:   ..:|.|      ..|||.|    ..|..|||:|||||:|:..|::||.....||
Human   184 RLCNALLY---GGAYPPPCKKELAASLALGLELSERSVRVYHECFGKCKGLLVPELYSSPSAACI 245

  Fly   255 KCLECDGWFSPQKFVGHVHRKFENHTCHWGFDSRNWHDYLHVALDVENREKYQII---LDQLKEV 316
            :||:|...:.|.|||.|.|:..||.||||||||.||..|:.::.|...:|:...:   ||.:||
Human   246 QCLDCRLMYPPHKFVVHSHKALENRTCHWGFDSANWRAYILLSQDYTGKEEQARLGRCLDDVKE- 309

  Fly   317 ELKEMHKAQRELEHKKRKAEMLMDDGMLGSGPVLGLAGHPHGLVGALAPPPPPPMKQPQMD---- 377
                  |.....::|:|...:..:                           ||...:|:.|
Human   310 ------KFDYGNKYKRRVPRVSSE---------------------------PPASIRPKTDDTSS 341

  Fly   378 ---IPSGKKQ----LQQLKGATVAASALEYQYQVMYAHCVQKEREREREHLPHSHPLPRQHRAVL 435
               .||.|.:    |:.|.|::..:..           ||.                |||.
Human   342 QSPAPSEKDKPSSWLRTLAGSSNKSLG-----------CVH----------------PRQR---- 375

  Fly   436 VATTPYPHLPQYPTPPTLNSSSAFRPWGPDTTKAFLHAYGATLSSLPYACQEPPELQNPERVVRS 500
                                .||||||.|        |..|:...|           :|......
Human   376 --------------------LSAFRPWSP--------AVSASEKEL-----------SPHLPALI 401

  Fly   501 TDKRYAERTYQ----PNVALAP--RKSILSKERDKDRERMEREVMERQRLREKETDHQVVHIKQE 559
            .|..|:.::::    |||||||  ::.::|
Human   402 RDSFYSYKSFETAVAPNVALAPPAQQKVVS----------------------------------- 431

  Fly   560 RSQTPTPPTASPPDGVVLPLDVVEPPHPSSSGSNSPLPAHLPAAPATAPPNAGGAPPTPTNLR-- 622
                 :||.|:.......||.....|.      ...|....|.||.|..|.|  ||....:..
Human   432 -----SPPCAAAVSRAPEPLATCTQPR------KRKLTVDTPGAPETLAPVA--APEEDKDSEAE 483

  Fly   623 -NMRSPEEFSAGGSNEITSSTSPHHQQSSHHQVVQPTAGAPPPSQHIIATVNQHAKLLPSSSSLP 686
             .:.|.||.:.  ::.::|.:||....||..:    ..|:|            .|:.||  |::|
Human   484 VEVESREECTF--TSSLSSLSSPSFTSSSSAK----DLGSP------------GARALP--SAVP 528

  Fly   687 NGNGSSSLAATNNEPSRIRINKNLMSQQPVVAVSGMTPHHHQHHPTHMHHFSHGYYKSQASSPTQ 751
            :                                                          |::|..
Human   529 D----------------------------------------------------------AAAPAD 535

  Fly   752 SSSAGLNLSTHSSNVVSSPHHATQPKTHHSSVGSGNHGLQNGKPHLGSEFELSTDTDDTDSLNGE 816
            :.|                                  ||:....||....|...||.:..
Human   536 APS----------------------------------GLEAELEHLRQALEGGLDTKEAK----- 561

  Fly   817 PDSSAMLPPWEQAVESLRETRPKDRERVLLILQRLLQENDQYRYNNIQLSELLHKQDAHIADLTE 881
                      |:.:..:.:.|.|..|::...||.....:.:..:..:...|.|.:......:|.:
Human   562 ----------EKFLHEVVKMRVKQEEKLSAALQAKRSLHQELEFLRVAKKEKLREATEAKRNLRK 616

  Fly   882 QLQRYRRQFEEQVCKVDLRKMPFK---HQTRLENV----VEAGRGEAEEDEELEE---------- 929
            :::|.|.:.|:::.:.:..::..|   .|.|...|    .||||..|:...::|:
Human   617 EIERLRAENEKKMKEANESRLRLKRELEQARQARVCDKGCEAGRLRAKYSAQIEDLQVKLQHAEA 681

  Fly   930 DEMEDRANNNNQQELSPLIKAPANGLRRSVTP---PNCCASEG 969
            |..:.||:...::|....::.....|:..:.|   |....|||
Human   682 DREQLRADLLREREAREHLEKVVKELQEQLWPRARPEAAGSEG 724

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Snoo	NP_609164.3	DHD_Ski_Sno	116..206	CDD:410782	58/89 (65%)
		c-SKI_SMAD_bind	226..317	CDD:198114	43/93 (46%)
		AF-4	637..>789	CDD:461550	15/151 (10%)
SKI	XP_005244832.1	DHD_Ski	91..192	CDD:410786	62/104 (60%)
		c-SKI_SMAD_bind	217..311	CDD:462602	43/100 (43%)
		PTZ00449	<318..478	CDD:185628	53/304 (17%)
		SMC_prok_B	540..>711	CDD:274008	33/185 (18%)