DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Snoo and skor1b

DIOPT Version :9

Sequence 1:	NP_001097115.1	Gene:	Snoo / 5740414	FlyBaseID:	FBgn0085450	Length:	1223	Species:	Drosophila melanogaster
Sequence 2:	NP_001038598.1	Gene:	skor1b / 567457	ZFINID:	ZDB-GENE-050419-82	Length:	751	Species:	Danio rerio

Alignment Length:	884	Identity:	187/884 - (21%)
Similarity:	299/884 - (33%)	Gaps:	255/884 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    82 CSTRGTPPQIYS-PATPPRELSQPILSVADAGCGELYETKLEGKTIGCFSVGGEMRLCLPQFLNN 145
            ||......|.|| |...|.::|               ||.|.|..|....:.|:.||||.|..|.
Zfish    16 CSPNSKDLQSYSGPPLKPNQVS---------------ETSLYGIPIVSLVIDGQERLCLAQISNT 65

  Fly   146 VLNDFSLEQINRIFDELGIYCSQCTHDQLVEFKAAKILPSDVKASGLITRTDAERLCAALL--HR 208
            :|.::|..:|:.....|||.|.|||..||...:.|..:|...:..|:||:.:|||||.:.|  |.
Zfish    66 LLKNYSYNEIHNRRVALGITCVQCTPVQLEILRRAGAMPISSRRCGMITKREAERLCKSFLGAHS 130

  Fly   209 SDRNSYVPIESLAKGALSFHVYHKCFGKCEGICTPDMYSYQKPTCIKCLECDGWFSPQKFVGHVH 273
            ..:   :| |:.|     |.|.|:|.....|...|..|:..:..||||..|:.:|||.||:.|.|
Zfish   131 PPK---LP-ENFA-----FDVSHECAWGSRGNFIPARYNSSRAKCIKCSFCNMYFSPNKFIFHSH 186

  Fly   274 RKFENHTCHWGFDSRNWHDY-LHVALDVENREKYQIILDQLKEVELKEMHKAQRELEHKKRKAEM 337
            |..|:.  :...|:.|::.: .|:.|..:|                     :..::.|.....:.
Zfish   187 RTPESK--YTQPDAANFNSWRRHLKLSDKN---------------------SSDDVIHAWEDVKA 228

  Fly   338 LMDDGMLGSGPVLGLAGHPHGLVGALAPPPPPPMKQPQ---MDIPSGKKQLQQLKGATVAASALE 399
            :.:.|.......:|.:.         :.|..||..|.|   .|:|  .|.|:
Zfish   229 MFNGGSRKRTLPIGRSE---------SSPSQPPRGQTQGEPSDVP--HKTLR------------- 269

  Fly   400 YQYQVMYAHCVQKEREREREHLPHS------HPLPRQHRAVLVATTP--YPHLPQYPT------- 449
                     |   |.:|....:|.|      .|:|.:...:|....|  :||...:|.
Zfish   270 ---------C---EDDRVNVTMPSSIRSYPVIPVPSKSFGMLQKIPPPLFPHPYGFPAFGLCQKK 322

  Fly   450 --------PPTLNSSSAFRPWGPDTTKAFLHAYGATLSSLP-----YACQEPP---------ELQ 492
                    |...|.|..|.|...|:.......:..|..||.     :|..:||         ||.
Zfish   323 DDGEVMGEPNKTNLSGVFWPSPKDSAYTSFPMFWPTTGSLAMPTYHHAQPKPPSDVLCARHNELD 387

  Fly   493 NPERVVRSTDKRYAERTYQPNVALAPRKSILSKERDKDRERMEREVMERQRLREKETDHQVVHIK 557
            ..|:..|||.              .|:.|:|..||....:....|       .:|..|
Zfish   388 VSEQSDRSTS--------------TPKDSLLDNERCSSTQSTRNE-------EDKSGD------- 424

  Fly   558 QERSQTPTPPTASPPDGVVLPLDVVEPPHPSSSGSNSPLPAHLPAAPATAPPNAGGAPPTPTNLR 622
            :.||....|||:.       .:..:....|......|....:....|.:.|.:...:|...:...
Zfish   425 ESRSIEGIPPTSR-------KISYISAFRPVVKDVESIAKLYGNRGPYSGPRSGYMSPDFLSESS 482

  Fly   623 NMRSPEEFSAGGSNEITSSTSPHHQQSSHHQVVQPTAGAPPPSQHIIATVNQHAKLLPSSSSLPN 687
            :.||.       |.::.|...|.....||.        |....:.:..:|:....  |.|.:|..
Zfish   483 SYRSV-------SPDVDSVDDPDVDVESHK--------AHEDEECLQLSVDDRRS--PHSLTLAQ 530

  Fly   688 GNG-------------SSSLAATNNEPSRIRINKNLMSQQPVVAVSGMTPHHHQH---------- 729
            ..|             .:.|.:||:..:|               .|.|..|.::|
Zfish   531 SEGVKGQDQENTQMHTLNDLHSTNSSETR---------------PSDMESHGNKHTTRFEVYARE 580

  Fly   730 HPTHMHHFSHGYYKSQASSPTQSSSAGLNLSTHSSNVVSSPHHATQPKTHHSSVGSGNHGLQNGK 794
            ...|:|..|..|:.|..:...::|...::....||.|     ...:||.|..........|:...
Zfish   581 RDEHVHQMSTSYFGSATTYQRETSVKDVHEEEPSSTV-----EEMEPKNHQDENNISEERLKEPN 640

  Fly   795 PHLGSEFELSTDTDDTDSLNGEPDSSAMLPPWEQAVESLRETRPKDRERVLLILQRLLQENDQYR 859
            .....|..:..||.:..||            .|:.:||:.:..          ||:.|.|
Zfish   641 DVCADEEAICKDTGNRGSL------------IEKNIESMAKEE----------LQKQLVE----- 678

  Fly   860 YNNIQLSELLHKQDAHIAD-LTEQLQR---YRRQFEEQV 894
              .::|.:.|.::..::.| ..:|::|   ||.:..:|:
Zfish   679 --QVELRKKLEREFQNLKDSFQDQMKRELSYREEMVQQL 715

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Snoo	NP_001097115.1	Ski_Sno	114..207	CDD:280577	35/94 (37%)
Snoo	NP_001097115.1	c-SKI_SMAD_bind	226..317	CDD:198114	26/91 (29%)
skor1b	NP_001038598.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..30		5/13 (38%)
		Ski_Sno	34..127	CDD:280577	35/107 (33%)
		c-SKI_SMAD_bind	140..230	CDD:285935	27/112 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	234..267		8/43 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	386..434		15/75 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	459..569		23/141 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	600..635		7/39 (18%)
		RILP-like	<670..>716	CDD:304877	12/63 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910