DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Snoo and Skor1

DIOPT Version :9

Sequence 1:	NP_001097115.1	Gene:	Snoo / 5740414	FlyBaseID:	FBgn0085450	Length:	1223	Species:	Drosophila melanogaster
Sequence 2:	NP_001363881.1	Gene:	Skor1 / 315748	RGDID:	1307687	Length:	964	Species:	Rattus norvegicus

Alignment Length:	1330	Identity:	257/1330 - (19%)
Similarity:	374/1330 - (28%)	Gaps:	546/1330 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 YQTSATKSLQGPGHALTTAGVLDIVTNGRSESPGLNGKCQASPPVVALIKKEILSSPEPQDLHHH 80
            :||.........|..|.:.|:..:.|   ...||..|.                |||.
  Rat    20 FQTENRIGFLAAGAFLRSGGMEALTT---QLGPGREGS----------------SSPN------- 58

  Fly    81 ECSTRGTPPQIYSPATPPRELSQPILSVADAGCGELYETKLEGKTIGCFSVGGEMRLCLPQFLNN 145
              |.:...|...|.|..|.::.               ||.|.|..|....:.|:.||||.|..|.
  Rat    59 --SKQELQPYSGSSALKPNQVG---------------ETSLYGVPIVSLVIDGQERLCLAQISNT 106

  Fly   146 VLNDFSLEQINRIFDELGIYCSQCTHDQLVEFKAAKILPSDVKASGLITRTDAERLCAALL--HR 208
            :|.::|..:|:.....|||.|.|||..||...:.|..:|...:..|:||:.:|||||.:.|  |:
  Rat   107 LLKNYSYNEIHNRRVALGITCVQCTPVQLEILRRAGAMPISSRRCGMITKREAERLCKSFLGEHK 171

  Fly   209 SDRNSYVPIESLAKGALSFHVYHKCFGKCEGICTPDMYSYQKPTCIKCLECDGWFSPQKFVGHVH 273
            ..:   :| |:.|     |.|.|:|.....|...|..|:..:..||||..|..:|||.||:.|.|
  Rat   172 PPK---LP-ENFA-----FDVVHECAWGSRGSFIPARYNSSRAKCIKCGYCSMYFSPNKFIFHSH 227

  Fly   274 RKFENHTCHWGFDSRNWHDYLHVALDVENREKYQIILDQLKEVELKEMHKAQRELEHKKRKAEML 338
            |.               .|..:...|..|...::      :.::|.: ..|..||.|.....:.:
  Rat   228 RT---------------PDAKYTQPDAANFNSWR------RHLKLSD-KSATDELSHAWEDVKAM 270

  Fly   339 MDDGML----------GSGPVLGLAGHPHGLVGA---------LAPPPPPPMKQPQMDIPSGKKQ 384
            .:.|..          |.|...|..|...|..|.         :||.|||            .|.
  Rat   271 FNGGTRKRTFSLQGGGGGGANSGSGGAGKGGAGGGGGPGCGSEMAPGPPP------------HKS 323

  Fly   385 LQQLKGATVAASALEYQYQVMYAHCVQKEREREREHLPHSHPLPRQHRAV-LVATTPYPHLPQYP 448
            |:                      |.:.|...     |...|.|...||: |.|....|..|..|
  Rat   324 LR----------------------CGEDEASG-----PPGPPPPHPQRALGLAAAANGPAGPGGP 361

  Fly   449 TPPTLNSSSAFR--PWGPDTTKAFLHAYGATLSSLPYACQEPPELQNPERVVRSTDKRYAERTYQ 511
                 ..|:..|  |..|..:|.|     ..|..||     ||...:|          |.   :.
  Rat   362 -----GGSAGVRSYPVIPVPSKGF-----GLLQKLP-----PPLFPHP----------YG---FP 398

  Fly   512 PNVALAPRKSILSKERDKDRERMEREVMERQRLREKETDHQVVHIKQERSQTPT----------- 565
            ....|.|:|                             |..|:...:.:....|
  Rat   399 TAFGLCPKK-----------------------------DDPVLVAGEPKGGPGTGSGGGAGTAAG 434

  Fly   566 ---------PPTASP------------PDGVV----------------------------LPLDV 581
                     ||.|.|            |.|..                            ||:
  Rat   435 AGGPGAGHLPPGAGPGPGGGTMFWGHQPSGAAKDAAAVAAAAAAATVYPTFPMFWPAAGSLPV-- 497

  Fly   582 VEPPHPSSSGSNSPLPAHLPAAPATAPPNAGGAPPTPTNLRNMRSPEEFSAGGSNEITSSTS--P 644
              ||:|::......:.|.:.||.|.|...|||.  .|.:|......:|.|.|......|:.|  |
  Rat   498 --PPYPAAQSQAKAVAAAVAAAAAAAAAAAGGG--GPESLDGAEPAKEGSLGTEERCPSALSRGP 558

  Fly   645 HHQQSSHHQV---VQPTAGAPPPSQHIIATVNQHAKLLPSSSSLPNGNGSSSLAATNNEPSRIRI 706
            ..:..:...:   :.|.|..|||.....:.|:....::..:.|:....||:. .|..:.|:|
  Rat   559 LDEDGADEALPPSLAPLAPPPPPPARKSSYVSAFRPVVKDAESIAKLYGSAR-EAYGSGPAR--- 619

  Fly   707 NKNLMSQQPVVAVSGMTPHHHQHHPTHMHHFSHGY----YKSQASSPTQSSSAGLNLSTHSSNVV 767
                 ...|.....|                  ||    :.|:.||...|:|..::.:......|
  Rat   620 -----GPVPGTGTGG------------------GYVSPDFLSEGSSSYHSASPDVDTADEPEVDV 661

  Fly   768 SS----PHHATQPKTHHS--SVGSGNHGLQ-NGKPHLGSEFELSTDTDDTDSLNGEPDSSAMLPP 825
            .|    .....|..|..|  |.|.|..|.| .|.|.:.|    |.....|||.:|:
  Rat   662 ESNRFPDEEGAQEDTEPSVPSTGGGPDGDQPAGPPSVTS----SGADGPTDSADGD--------- 713

  Fly   826 WEQAVESLRETRPKDRERVLLILQRLLQENDQYRYNNIQLSELLHKQDAHIADLTEQLQRYRRQF 890
                     ..||
  Rat   714 ---------SPRP---------------------------------------------------- 717

  Fly   891 EEQVCKVDLRKMPFKHQTRLENVVEAGRGEAEEDEELEEDEMEDRANNNNQQELSPLIKAPANGL 955

  Rat   718 ----------------------------------------------------------------- 717

  Fly   956 RRSVTPPNCCASEGGDCEKPDEPESKRIKLQVGEKAEDKQVENEESPSNGTESHDLEKLEKNDDK 1020
            ||.:.||....|..||.                 .|:|.....|.||.||  .::|.      :.
  Rat   718 RRRLGPPPAIRSAFGDL-----------------VADDVVRRTERSPPNG--GYELR------EP 757

  Fly  1021 TDPTNNPKSPQ---PSQISSDDEMEEDDEDEDEEDEDEEVQVEA------PHSSALATPPTATTP 1076
            ..|...|.:.:   |                   :.||.|:..|      |.:|.|.||.|....
  Rat   758 CGPLGGPAAAKVYVP-------------------ERDEHVKSAAAAAALGPAASYLCTPETHEPD 803

  Fly  1077 LSPDSAATAGQLFDSSNSSDESSMKK--------------AQMSACHALEKMSSNVGSDENNQRL 1127
            ...:.:.||..|....:.||:.|:.:              ..::....:||...|:..:|..:.|
  Rat   804 KEDNHSTTADDLETRKSFSDQRSVSQPSPANTDRGEDGLTLDVTGTQLVEKDIENLAREELQKLL 868

  Fly  1128 AE------------ESQEDEAEEDPEEEDSDDDEMPLQQRQ-----------QQQRQRVAPQNVL 1169
            .|            :|.:|..::..:.|.:..:|| :||.|           |:::.|.|.|..|
  Rat   869 LEQMELRKKLEREFQSLKDNFQDQMKRELAYREEM-VQQLQIVRDTLCNELDQERKARYAIQQKL 932

  Fly  1170 SGPSVAGHH-----PAPAH--------PPM 1186
            .....|.||     ..|.|        ||:
  Rat   933 KEAHDALHHFSCKMLTPRHCTGNCSFKPPL 962

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Snoo	NP_001097115.1	Ski_Sno	114..207	CDD:280577	35/94 (37%)
Snoo	NP_001097115.1	c-SKI_SMAD_bind	226..317	CDD:198114	23/90 (26%)
Skor1	NP_001363881.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	45..72		10/54 (19%)
		Ski_Sno	75..168	CDD:367087	34/107 (32%)
		c-SKI_SMAD_bind	180..272	CDD:198114	29/118 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	278..365		25/130 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	414..452		5/37 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	525..587		16/63 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	610..766		49/346 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	793..842		10/48 (21%)
		CCDC66	<850..934	CDD:373669	19/84 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	154	1.000	Inparanoid score	I4233
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.960