DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Snoo and Ski

DIOPT Version :9

Sequence 1:	NP_001097115.1	Gene:	Snoo / 5740414	FlyBaseID:	FBgn0085450	Length:	1223	Species:	Drosophila melanogaster
Sequence 2:	XP_017449382.2	Gene:	Ski / 313757	RGDID:	1565591	Length:	727	Species:	Rattus norvegicus

Alignment Length:	1020	Identity:	243/1020 - (23%)
Similarity:	354/1020 - (34%)	Gaps:	355/1020 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 PMISTVLKKYQTSATKSLQGPGHALTTAGVLDIVTNGRSESPGLNGKCQASPPVVALIKKEILSS 71
            |.:...|:::..|:..||.||. |.:.....:......::..|           .|.:...:.::
  Rat    15 PGLQKTLEQFHLSSMSSLGGPA-AFSARWAQEAYKKESAKEAG-----------AATVPAPVPTA 67

  Fly    72 PEPQDLHHHECSTRGTPPQIYSPA--TPPRELSQPILSVADAGCGELYETKLEGKTIGCFSVGGE 134
            .||             ||.::.||  .||..|..|....:|... |..||.|||:||.||.||||
  Rat    68 AEP-------------PPVLHLPAIQPPPPVLPGPFFMPSDRST-ERCETVLEGETISCFVVGGE 118

  Fly   135 MRLCLPQFLNNVLNDFSLEQINRIFDELGIYCSQCTHDQLVEFKAAKILPSDVKASGLITRTDAE 199
            .||||||.||:||.||||:|||.:.|||.||||:||.|||...|...|||....:.||||:||||
  Rat   119 KRLCLPQILNSVLRDFSLQQINSVCDELHIYCSRCTADQLEILKVMGILPFSAPSCGLITKTDAE 183

  Fly   200 RLCAALLHRSDRNSYVP------IESLAKG----ALSFHVYHKCFGKCEGICTPDMYSYQKPTCI 254
            |||.|||:   ..:|.|      ..|||.|    ..|..|||:|||||:|:..|::||.....||
  Rat   184 RLCNALLY---GGAYPPPCKKELAASLALGLELSERSVRVYHECFGKCKGLLVPELYSSPSAACI 245

  Fly   255 KCLECDGWFSPQKFVGHVHRKFENHTCHWGFDSRNWHDYLHVALDVENREKYQII---LDQLKEV 316
            :||:|...:.|.|||.|.|:..||.||||||||.||..|:.::.|...:|:...:   ||.:||
  Rat   246 QCLDCRLMYPPHKFVVHSHKALENRTCHWGFDSANWRAYILLSQDYTGKEEQARLGRCLDDVKE- 309

  Fly   317 ELKEMHKAQRELEHKKRKAEMLMDDGMLGSGPVLGLAGHPHGLVGALAPPPPPPMKQPQMDIPSG 381
                  |.....::|:|...:                            ..||...:|:.|..|.
  Rat   310 ------KFDYANKYKRRVPRV----------------------------SEPPASIRPKTDDTSS 340

  Fly   382 K--------KQLQQLKGATVAASALEYQYQVMYAHCVQKEREREREHLPHSHPLPRQHRAVLVAT 438
            :        ||...|:  |:|.|:                    .:.|..:||..|
  Rat   341 QSPASSEKDKQSTWLR--TLAGSS--------------------NKSLGCAHPRQR--------- 374

  Fly   439 TPYPHLPQYPTPPTLNSSSAFRPWGPDTTKAFLHAYGATLSSLPYACQEPPELQNPERVVRSTDK 503
                             .||||||.|                   |.....:..:|.......|.
  Rat   375 -----------------LSAFRPWSP-------------------AVSASEKETSPHLPALIRDS 403

  Fly   504 RYAERTYQ----PNVALAPRKSILSKERDKDRERMEREVMERQRLREKETDHQVVHIKQERSQTP 564
            .|:.::::    |||||||                             .|..:||:
  Rat   404 FYSYKSFETAVAPNVALAP-----------------------------PTQQKVVN--------- 430

  Fly   565 TPPTASPPDGVVLPLDVVEPPHPSSSGSNSPLPAHLPAAPATAPPNAGGAP----PTPTNLRNMR 625
                 |||...|:            |.:..||...:.........:|.|||    |......:..
  Rat   431 -----SPPCTTVV------------SRAPEPLTTCIQPRKRKLTMDAPGAPDMLTPVAAAEEDKD 478

  Fly   626 SPEEFSAGGSNEITSSTSPHHQQSSHHQVVQPTAGAPPPSQHIIATVNQHAKLLPSSSSLPNGNG 690
            |..|.......|.|||.                                      ||.|.|:...
  Rat   479 SEAEVEVESREEFTSSL--------------------------------------SSLSSPSFTS 505

  Fly   691 SSSLAATNNEPSRIRINKNLMSQQPVVAVSGMTPHHHQHHPTHMHHFSHGYYKSQASSPTQSSSA 755
            |||.             |:|.|       .||      |.|                 |..:..|
  Rat   506 SSSA-------------KDLSS-------PGM------HAP-----------------PVAAPDA 527

  Fly   756 GLNLSTHSSNVVSSPHHATQPKTHHSSVGSGNHGLQNGKPHLGSEFELSTDTDDTDSLNGEPDSS 820
            ..              ||..|.           ||:....||....|...||.:..
  Rat   528 AA--------------HADAPS-----------GLEAELEHLRQALEGGLDTKEAK--------- 558

  Fly   821 AMLPPWEQAVESLRETRPKDRERVLLILQRLLQENDQYRYNNIQLSELLHKQDAHIADLTEQLQR 885
                  |:.:..:.:.|.|..|::...||.....:.:..:..:...|.|.:.......|.::::|
  Rat   559 ------EKFLHEVVKMRVKQEEKLTAALQAKRSLHQELEFLRVAKKEKLREATEAKRSLRKEIER 617

  Fly   886 YRRQFEEQVCKVDLRKMPFKHQTRLENVV-------EAGRGEAEEDEELEE----------DEME 933
            .|.:.|:::.:.:..::..|.:......|       ||||..|:...::|:          |..:
  Rat   618 LRAENEKKMKEANESRVRLKRELEQARQVRVCDKGCEAGRLRAKYSAQIEDLQAKLQHAEADREQ 682

  Fly   934 DRANNNNQQELSPLIKAPANGLRRSVTPPNCCASEGGDCEKPDEP 978
            .||:...::|....::.....|:..:.|.....:.||:.....:|
  Rat   683 LRADLLREREAREHLEKVVKELQEQLWPRPRPENSGGESNAELDP 727

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Snoo	NP_001097115.1	Ski_Sno	114..207	CDD:280577	60/92 (65%)
Snoo	NP_001097115.1	c-SKI_SMAD_bind	226..317	CDD:198114	43/93 (46%)
Ski	XP_017449382.2	DHD_Ski	91..192	CDD:410786	62/104 (60%)
		c-SKI_SMAD_bind	217..312	CDD:198114	44/101 (44%)
		SMC_prok_B	537..>708	CDD:274008	31/185 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	120	1.000	Domainoid score	I5617
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002607
OrthoInspector	1	1.000	-	-		otm44635
orthoMCL	1	0.900	-	-		OOG6_107704
Panther	1	1.100	-	-	O	PTHR10005
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.910