Protein Alignment Snoo and skib

DIOPT Version :10

• Sequence 1: NP_609164.3
• Gene: Snoo / 5740414
• FlyBaseID: FBgn0085450
• Length: 1223
• Species: Drosophila melanogaster
• Sequence 2: NP_571013.1
• Gene: skib / 30113
• ZFINID: ZDB-GENE-990715-10
• Length: 695
• Species: Danio rerio
• Alignment Length: 1037
• Identity: 251/1037 - (24%)
• Similarity: 374/1037 - (36%)
• Gaps: 391/1037 - (37%)

  Fly     7 PMISTVLKKYQTSATKSLQGPGHALTTAGVLDIV--TNGRSESPGLNGKCQASPPVVALIKKEIL 69
            |.:...||::..|:..||.||. |.:.....|::  .:|:|                    .|:|
Zfish    11 PGLQQTLKQFHLSSMSSLGGPA-AFSARWQQDMLFKKDGKS--------------------AEVL 54

  Fly    70 SSPEPQDLHHHECSTRGTPPQIYSPATPPRELSQPILSVADAGCGELYETKLEGKTIGCFSVGGE 134
            .:...|           |||.:..|...|.:.|.           |..||.||.:||.||.||||
Zfish    55 VNLPAQ-----------TPPVMPGPLFIPSDRST-----------ERCETVLERETISCFVVGGE 97

  Fly   135 MRLCLPQFLNNVLNDFSLEQINRIFDELGIYCSQCTHDQLVEFKAAKILPSDVKASGLITRTDAE 199
            .||||||.||:||.||||:|||.:.|:|.||||:||.|||...|...|||....:.||||:||||
Zfish    98 KRLCLPQILNSVLRDFSLQQINSVCDDLHIYCSRCTADQLEILKVMGILPFSAPSCGLITQTDAE 162

  Fly   200 RLCAALLH------RSDRNSYVPIESLAKGALSFHVYHKCFGKCEGICTPDMYSYQKPTCIKCLE 258
            |||.||::      .:|:.....|| |.:...||.|||:|||||:|:..|::|:.....||:||:
Zfish   163 RLCNALIYGGTFPPHADKELSCSIE-LERTEKSFKVYHECFGKCKGLFVPELYTSPNAACIQCLD 226

  Fly   259 CDGWFSPQKFVGHVHRKFENHTCHWGFDSRNWHDYLHVALDVENREK---YQIILDQLK-EVELK 319
            |...|...|||.|.|::.||.||||||||.||..|:.:..|...:|:   .|.:|.:|| :.|:.
Zfish   227 CRLMFPTHKFVVHSHKRLENRTCHWGFDSSNWRAYILLDQDYSEKEENSTLQQLLTELKGKFEMG 291

  Fly   320 EMHKAQRELEHKKRKAEMLMDDGMLGSGPVLGLAGHPHGLVGALAPPPPPPMKQPQMDIPSGKKQ 384
            ..||...:                                  |.:|.|...:|..:...||..::
Zfish   292 NKHKTSYK----------------------------------AYSPIPSKKLKHDRSRSPSADRE 322

  Fly   385 -----LQQLKGATVAASALEYQYQVMYAHCVQKEREREREHLPHSHPLPRQHRAVLVATTPYPHL 444
                 ||.|     ||||.:...|:.:     |:|
Zfish   323 KPADWLQSL-----AASANKDLKQLQF-----KQR------------------------------ 347

  Fly   445 PQYPTPPTLNSSSAFRPWGPDTTKAFLHAYGATLSSLPYACQEPPELQNPERVVRSTDKRYAERT 509
                       .||||||.|....|
Zfish   348 -----------PSAFRPWSPRVPSA---------------------------------------- 361

  Fly   510 YQPNVALAPRKSILSKERDKDRERMEREVMERQRLREKETDHQVVHIKQERSQTPTPPTASPPDG 574
                                                |:||.:.    |.|||...|....:.|:
Zfish   362 ------------------------------------ERETPNH----KYERSLAKTQDNLAVPN- 385

  Fly   575 VVLPLDVVEPPHPSSSGSNSPLPAHLPAAPATAPPNAGGAPPTPTNLRNMRSPEEFSAGGSNEIT 639
            |.||:         ::..|:..|||..:.| |...|.|.                         |
Zfish   386 VSLPI---------AAFKNNEQPAHRFSQP-TESHNTGK-------------------------T 415

  Fly   640 SSTSPHHQQSSHHQVVQPTAGAPPPSQHIIATVNQHAKLLPSSSSLPNGNGSSSLAATNNEPSRI 704
            .|:.|..:..|..:..||..                               .:||..    |.:.
Zfish   416 ESSRPRKRWPSAERQSQPAT-------------------------------KTSLCT----PIKQ 445

  Fly   705 RINKNLMSQQPV-------VAVSGMTPHHHQHHPTHMHHFSHGYYKSQASSPTQSSSAGLNLSTH 762
            |:.:|..|.:.:       ||||                      :|..|.|..:....:.||.|
Zfish   446 RLQENHDSDEEIQVDNCAEVAVS----------------------RSLMSPPFTNGVGVMTLSPH 488

  Fly   763 SSNVVSSPHHATQPKTHHSSVGSGNHGLQNGKPHLGSEFELSTDTDDTDSLNGEPDSSAMLPPWE 827
            ||                :.|..|...|..|  |. ||.||...|..:|..:.|..        |
Zfish   489 SS----------------AEVHDGRARLAAG--HC-SELELLKQTLSSDLSSKEAR--------E 526

  Fly   828 QAVESLRETRPKDRERVLLILQ--RLLQENDQYRYNNIQLSELLHKQDAHIA--DLTEQLQRYRR 888
            :.::.:...|.|..|::...||  |.||:..::    :::::....::|..|  :|.::::|.|.
Zfish   527 KFLQEIIRMRVKQEEKLAAALQAKRSLQQELEF----VRVTKKGRLREAIEAKRNLRKEIERLRV 587

  Fly   889 QFEEQV------CKVDLRKMPFKHQTRL-ENVVEAGRGEAEEDEELEEDEME-DRANNNNQQELS 945
            :.|::|      |....|.:..:.:||: :...||||..|:...::|:.:|: .:|..:.:|...
Zfish   588 ECEKKVRDASESCDRLKRDLDRERRTRVCDKNCEAGRLRAKYSSQIEDLQMKLQQAEVDREQLRE 652

  Fly   946 PLIKAPANGLRRSVTPPNCCASEGGDCEKPDEPESKRIKLQVGEKAEDKQVENEESPSNGTE 1007
            .|:|.                   .|..:..|...|.::.|:|.|||   .|....|:.|.:
Zfish   653 DLLKE-------------------RDARQNLERVVKELQEQLGHKAE---TEANTQPTKGDQ 692

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Snoo	NP_609164.3	DHD_Ski_Sno	116..206	CDD:410782	56/89 (63%)
		c-SKI_SMAD_bind	226..317	CDD:198114	43/94 (46%)
		AF-4	637..>789	CDD:461550	26/158 (16%)
skib	NP_571013.1	DHD_Ski	70..171	CDD:410786	60/111 (54%)
		c-SKI_SMAD_bind	194..288	CDD:462602	43/93 (46%)
		SMC_prok_B	509..>675	CDD:274008	39/196 (20%)