Protein Alignment Snoo and skia

DIOPT Version :10

• Sequence 1: NP_609164.3
• Gene: Snoo / 5740414
• FlyBaseID: FBgn0085450
• Length: 1223
• Species: Drosophila melanogaster
• Sequence 2: NP_571010.3
• Gene: skia / 30101
• ZFINID: ZDB-GENE-990715-9
• Length: 727
• Species: Danio rerio
• Alignment Length: 946
• Identity: 248/946 - (26%)
• Similarity: 355/946 - (37%)
• Gaps: 287/946 - (30%)

  Fly     7 PMISTVLKKYQTSATKSLQGPGHALTTAGVLDIVTNGRSESPGLNGKCQASPPVVALIKKEILSS 71
            |.:...||::..|:..||.||. |.:.....|:                       |.||:....
Zfish    13 PGLQQTLKQFHLSSMISLGGPA-AFSARWQHDL-----------------------LFKKDGKDI 53

  Fly    72 PEPQDLHHHECSTRGTPPQIYSPATPPRELSQPILSVADAGCGELYETKLEGKTIGCFSVGGEMR 136
            |||. ||             ..|..||..:..|:...:|... |..||.|||:||.||.||||.|
Zfish    54 PEPV-LH-------------LPPMQPPPVMPGPLFIPSDRST-ERCETVLEGETISCFVVGGEKR 103

  Fly   137 LCLPQFLNNVLNDFSLEQINRIFDELGIYCSQCTHDQLVEFKAAKILPSDVKASGLITRTDAERL 201
            |||||.||.||.||||:|||.:.|:|.||||:||.|||...|...|||....:.||||:||||||
Zfish   104 LCLPQILNTVLRDFSLQQINSVCDDLHIYCSRCTADQLEILKVMGILPFAAPSCGLITKTDAERL 168

  Fly   202 CAALLH------RSDRNSYVPIESLAKGALSFHVYHKCFGKCEGICTPDMYSYQKPTCIKCLECD 260
            |.||::      .|.:..|..|| |.....||.:||:|||||:|:..|::|:.....||:|::|.
Zfish   169 CNALIYGGTYPPHSKKELYGSIE-LELTEKSFKIYHECFGKCKGLLVPELYTSPNAPCIQCMDCR 232

  Fly   261 GWFSPQKFVGHVHRKFENHTCHWGFDSRNWHDYLHVALDV---ENREKYQIILDQLKEVELKEMH 322
            ..:...|||.|.|:..||.||||||||.||..|:.::.|.   |.:.:.:.:||.:||
Zfish   233 LMYPTHKFVVHSHKSLENRTCHWGFDSANWRAYVLLSPDYTGKEEKARLEQLLDDIKE------- 290

  Fly   323 KAQRELEHK-KRKAEMLMDDGMLGSGPVLGLAGHPHGLVGALAPPPPPPMKQPQMD-----IPSG 381
              :.:..:| ||||....|                           |.|.|:|:.|     .|||
Zfish   291 --KFDFSNKYKRKASQASD---------------------------PIPAKKPKHDDFPAQSPSG 326

  Fly   382 KKQLQQLKGATVAASALEYQYQVMYAHCVQKEREREREHLPHSHPLPRQHRAVLVATTPYPHLPQ 446
            .|..|.....:::|||.:      ..:|:|                |||.
Zfish   327 DKDKQPDWLRSLSASANK------GLNCIQ----------------PRQR--------------- 354

  Fly   447 YPTPPTLNSSSAFRPWGPDTTKAFLHAYGATLSSLPYACQEPPELQNPERVVRSTDKRY--AERT 509
                     .||||||.|:.:.:.....|                 .|..::|.:...|  .|..
Zfish   355 ---------PSAFRPWSPNISVSDKDGAG-----------------RPASMLRESFYNYKSLESA 393

  Fly   510 YQPNVALAPRKSILSKERDKDRERMEREVMERQRLREKETDHQVVHIKQERSQ-TPTPPTASPPD 573
            ..|||||.|                                      .|:..| :|:.|::|.|.
Zfish   394 VAPNVALTP--------------------------------------PQKGGQASPSAPSSSHPH 420

  Fly   574 GVVLPLDVVEPPHPSS------SGSNSPLPAHLPAAPATAPPNAGGAPPTPTNLRNMRSPEEFSA 632
            |       .|....|.      :|...|.|.  |.|.|||      :.|.|.:.....|..|...
Zfish   421 G-------AESEGASRGRKRRLTGDTQPSPQ--PCAAATA------SKPLPASPEEHESDVEVEV 470

  Fly   633 GGSNEITSS----TSPHHQQSSHHQ--------------VVQPTAGAPPPSQHIIATVNQHAKLL 679
            ....|:|||    :||....||..:              ||.|.||  ||...:::....||.
Zfish   471 ESREELTSSLSSLSSPSFPSSSSAKDLSSPSGPVATLPAVVTPAAG--PPEGPLLSGGEGHAM-- 531

  Fly   680 PSSSSLPNGNGSSSLAATNNEPSRIRINKNLMSQQPVVAVSGMTPHHHQHHPTHMHHFSHGYYKS 744
                    .|..|.|     |..|..::..|.|::                  ....|.|...|.
Zfish   532 --------NNLESEL-----ETLRQALDNGLDSKE------------------SKEKFLHEIVKM 565

  Fly   745 QASSPTQSSSAGLNLSTHSSNVVSSPHHATQPKTHHSSVGSGNHGLQNGKPHLGSEFELSTDTDD 809
            :.....:..|| |.........:.....|.:.|...::....|...:..:....||.::....:.
Zfish   566 RVKQEEKLGSA-LQAKRSLQQELEFLRVAKKEKLREATEAKRNLRKEIERLRAESERKMREANES 629

  Fly   810 TDSLNGEPDSSAMLPPWEQAVES--LRETRPKDRERVLLILQRLLQENDQYRYNNIQLSELLHKQ 872
            ...|..|.:.:..|...::..|:  ||.......|.:.:.||....:.:|.|      ::|:|::
Zfish   630 RMRLKRELEQARQLRVCDKGCEAGRLRAKYSAQIEDLQVKLQHAEADREQLR------ADLIHER 688

  Fly   873 DAHIADLTEQLQRYRRQFEEQVCKVDLRKMPFKHQT 908
            :|.     |.|:|..::.:||:..    |.|.|:.|
Zfish   689 EAR-----EHLERVVKELQEQLWP----KSPSKNGT 715

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Snoo	NP_609164.3	DHD_Ski_Sno	116..206	CDD:410782	57/89 (64%)
		c-SKI_SMAD_bind	226..317	CDD:198114	40/93 (43%)
		AF-4	637..>789	CDD:461550	33/169 (20%)
skia	NP_571010.3	DHD_Ski	74..175	CDD:410786	60/101 (59%)
		c-SKI_SMAD_bind	198..292	CDD:462602	40/102 (39%)
		YhaN	537..>712	CDD:443752	37/213 (17%)