DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Snoo and Skor1

DIOPT Version :9

Sequence 1:	NP_001097115.1	Gene:	Snoo / 5740414	FlyBaseID:	FBgn0085450	Length:	1223	Species:	Drosophila melanogaster
Sequence 2:	NP_766034.2	Gene:	Skor1 / 207667	MGIID:	2443473	Length:	964	Species:	Mus musculus

Alignment Length:	1256	Identity:	246/1256 - (19%)
Similarity:	364/1256 - (28%)	Gaps:	508/1256 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly    97 PPRELS---------QPILSVADAGCGELYETKLEGKTIGCFSVGGEMRLCLPQFLNNVLNDFSL 152
            |.||.|         ||....:.....::.||.|.|..|....:.|:.||||.|..|.:|.::|.
Mouse    49 PGREGSSSPNSKQELQPYSGSSALKPNQVGETSLYGVPIVSLVIDGQERLCLAQISNTLLKNYSY 113

  Fly   153 EQINRIFDELGIYCSQCTHDQLVEFKAAKILPSDVKASGLITRTDAERLCAALL--HRSDRNSYV 215
            .:|:.....|||.|.|||..||...:.|..:|...:..|:||:.:|||||.:.|  |:..:   :
Mouse   114 NEIHNRRVALGITCVQCTPVQLEILRRAGAMPISSRRCGMITKREAERLCKSFLGEHKPPK---L 175

  Fly   216 PIESLAKGALSFHVYHKCFGKCEGICTPDMYSYQKPTCIKCLECDGWFSPQKFVGHVHRKFENHT 280
            | |:.|     |.|.|:|.....|...|..|:..:..||||..|..:|||.||:.|.||.
Mouse   176 P-ENFA-----FDVVHECAWGSRGSFIPARYNSSRAKCIKCGYCSMYFSPNKFIFHSHRT----- 229

  Fly   281 CHWGFDSRNWHDYLHVALDVENREKYQIILDQLKEVELKEMHKAQRELEHKKRKAEMLMDDGML- 344
                      .|..:...|..|...::      :.::|.: ..|..||.|.....:.:.:.|..
Mouse   230 ----------PDAKYTQPDAANFNSWR------RHLKLSD-KSATDELSHAWEDVKAMFNGGTRK 277

  Fly   345 ---------GSGPVLGLAGHPHGLVGA---------LAPPPPPPMKQPQMDIPSGKKQLQQLKGA 391
                     |.|...|..|...|..|.         :||.|||            .|.|:
Mouse   278 RTFSLQGGGGGGANSGSGGAGKGGAGGGGGPGCGSEMAPGPPP------------HKSLR----- 325

  Fly   392 TVAASALEYQYQVMYAHCVQKEREREREHLPHSHPLPRQHRAV-LVATTPYPHLPQYPTPPTLNS 455
                             |.:.|...     |...|.|...||: |.|....|..|..|     ..
Mouse   326 -----------------CGEDEAAG-----PPGPPPPHPQRALGLAAAASGPAGPGGP-----GG 363

  Fly   456 SSAFR--PWGPDTTKAFLHAYGATLSSLPYACQEPPELQNPERVVRSTDKRYAERTYQPNVALAP 518
            |:..|  |..|..:|.|     ..|..||     ||...:|          |.   :.....|.|
Mouse   364 SAGVRSYPVIPVPSKGF-----GLLQKLP-----PPLFPHP----------YG---FPTAFGLCP 405

  Fly   519 RKSILSKERDKDRERMEREVMERQRLREKETDHQVVHIKQERSQTPT------------------ 565
            :|                             |..|:...:.:....|
Mouse   406 KK-----------------------------DDPVLVAGEPKGGPGTGSSGGAGTAAGAGGPGAG 441

  Fly   566 --PPTASP------------PDGVV----------------------------LPLDVVEPPHPS 588
              ||.|.|            |.|..                            ||:    ||:|:
Mouse   442 HLPPGAGPGPGGGTMFWGHQPSGAAKDAAAVAAAAAAATVYPTFPMFWPAAGSLPV----PPYPA 502

  Fly   589 SSGSNSPLPAHLPAAPATAPPNAGGAPPTPTNLRNMRSPEEFSAGGSNEITSSTS--PHHQQSSH 651
            :......:.|.:.||.|.|...|||.  .|.:|......:|.|.|......|:.|  |..:..:
Mouse   503 AQSQAKAVAAAVAAAAAAAAAAAGGG--GPESLDGAEPAKEGSLGTEERCPSALSRGPLDEDGA- 564

  Fly   652 HQVVQPTAG----APPPSQHIIATVNQHAKLLPSSSSLPNGNGSSSLAATNNEPSRIRINKNLMS 712
            .:.:.|:.|    .|||.....:.|:....::..:.|:....||:. .|..:.|:|        .
Mouse   565 DEALPPSLGPLPPPPPPPARKSSYVSAFRPVVKDAESIAKLYGSAR-EAYGSGPAR--------G 620

  Fly   713 QQPVVAVSGMTPHHHQHHPTHMHHFSHGYYKSQASSPTQSSSAGLNLSTHSSNVVSSPHHATQPK 777
            ..|.....|                  ||.     ||...|..            ||.:|:..|
Mouse   621 PVPGTGTGG------------------GYV-----SPDFLSEG------------SSSYHSASP- 649

  Fly   778 THHSSVGSGNHGLQNGKPHLGSEFELSTDTDDTDSLNGEPDSSAMLPPWEQAVESLRETRPKDRE 842
                                        |.|..|    ||:
Mouse   650 ----------------------------DVDTAD----EPE------------------------ 658

  Fly   843 RVLLILQRLLQENDQYRYNNIQLSELLHKQDAHIADLTEQLQRYRRQFEEQVCKVDLRKMPFKHQ 907
                                                                  ||:....|
Mouse   659 ------------------------------------------------------VDVESNRF--- 666

  Fly   908 TRLENVVEAGRGEAEEDEELEEDEMEDRANNNNQQELSPLIKAPANGLRRSVTPPNCCASEGG-- 970
                           .|||..:|:.|.||.:...   .|....||.       ||:..:|...
Mouse   667 ---------------PDEEGAQDDTEPRAPSTGG---GPDGDQPAG-------PPSVTSSGADGP 706

  Fly   971 -DCEKPDEPESKR-------IKLQVGEKAEDKQV-ENEESPSNGTESHDLEKLEKNDDKTDPTNN 1026
             |....|.|..:|       |:...|:...|..| ..|.||.:|  .::|.         :|...
Mouse   707 TDSADGDSPRPRRRLGPPPAIRSAFGDLVADDVVRRTERSPPSG--GYELR---------EPCGP 760

  Fly  1027 PKSPQPSQISSDDEMEEDDEDEDEEDEDEEVQVEA------PHSSALATPPTATTPLSPDSAATA 1085
            ...|..:::.:             .:.||.|:..|      |.:|.|.||.|.......:.:.||
Mouse   761 LGGPGAAKVYA-------------PERDEHVKSTAVAAALGPAASYLCTPETHEPDKEDNHSTTA 812

  Fly  1086 GQLFDSSNSSDESSMKK--------------AQMSACHALEKMSSNVGSDENNQRLAE------- 1129
            ..|....:.||:.|:.:              ..::....:||...|:..:|..:.|.|
Mouse   813 DDLETRKSFSDQRSVSQPSPANTDRGEDGLTLDVTGTQLVEKDIENLAREELQKLLLEQMELRKK 877

  Fly  1130 -----ESQEDEAEEDPEEEDSDDDEMPLQQRQ-----------QQQRQRVAPQNVLSGPSVAGHH 1178
                 :|.:|..::..:.|.:..:|| :||.|           |:::.|.|.|..|.....|.||
Mouse   878 LEREFQSLKDNFQDQMKRELAYREEM-VQQLQIVRDTLCNELDQERKARYAIQQKLKEAHDALHH 941

  Fly  1179 -----PAPAH--------PPM 1186
                 ..|.|        ||:
Mouse   942 FSCKMLTPRHCTGNCSFKPPL 962

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Snoo	NP_001097115.1	Ski_Sno	114..207	CDD:280577	35/94 (37%)
Snoo	NP_001097115.1	c-SKI_SMAD_bind	226..317	CDD:198114	23/90 (26%)
Skor1	NP_766034.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	45..72		6/22 (27%)
		Ski_Sno	75..168	CDD:280577	34/92 (37%)
		c-SKI_SMAD_bind	180..272	CDD:198114	29/118 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	278..365		25/130 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	414..461		5/46 (11%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	525..587		16/64 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	610..768		50/351 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	794..842		10/47 (21%)
		RILP-like	<843..941	CDD:304877	20/98 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	185	1.000	Inparanoid score	I3926
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.960