Protein Alignment Snoo and Skil

DIOPT Version :9

• Sequence 1: NP_001097115.1
• Gene: Snoo / 5740414
• FlyBaseID: FBgn0085450
• Length: 1223
• Species: Drosophila melanogaster
• Sequence 2: NP_035516.2
• Gene: Skil / 20482
• MGIID: 106203
• Length: 675
• Species: Mus musculus
• Alignment Length: 619
• Identity: 174/619 - (28%)
• Similarity: 252/619 - (40%)
• Gaps: 200/619 - (32%)

  Fly    50 LNG-KCQASPPV-------------VALIKKEIL--------------------SSPEPQDL--- 77
            ||| :...||||             :..:|||.|                    |.||..:|
Mouse    18 LNGMEDDGSPPVKKMMTDIHANGKTLTKVKKEHLDDYGDASVEPDGEHAKRNRVSLPETLNLNPS 82

  Fly    78 --------HHHECSTRGTP-------------PQIYSPATPPRELSQPILSVADAGCGELYETKL 121
                    |....|:.|.|             |.::.|...|:.|..|:|..:|:.. ||.:|.|
Mouse    83 LKHTLAQFHLSSQSSLGGPAAFSARYSQESMSPTVFLPLPSPQVLPGPLLIPSDSST-ELTQTLL 146

  Fly   122 EGKTIGCFSVGGEMRLCLPQFLNNVLNDFSLEQINRIFDELGIYCSQCTHDQLVEFKAAKILPSD 186
            ||::|.||.||||.||||||.||:||.:|||:|||.:.|||.||||:||.|||...|...|||.:
Mouse   147 EGESISCFQVGGEKRLCLPQVLNSVLREFSLQQINTVCDELYIYCSRCTSDQLHILKVLGILPFN 211

  Fly   187 VKASGLITRTDAERLCAALLHR---SDRNSYVPIES----LAKGALSFHVYHKCFGKCEGICTPD 244
            ..:.||||.|||:|||.|||..   ....|.:|.:|    |.:...:|.|.|:|.|||:|:..|.
Mouse   212 APSCGLITLTDAQRLCNALLRPRTFPQNGSILPAKSSLAQLKETGSAFEVEHECLGKCQGLFAPQ 276

  Fly   245 MYSYQKPTCIKCLECDGWFSPQKFVGHVHRKFENHTCHWGFDSRNWHDYLHV---ALDVENREKY 306
            .|......||:||||.|.|:||.||.|.||..:..||||||:|..||.||||   .|.....:|.
Mouse   277 FYVQPDAPCIQCLECCGMFAPQTFVMHSHRSPDKRTCHWGFESAKWHCYLHVNQKYLGTPEEKKL 341

  Fly   307 QIILDQLKEVELKEMHKAQRELEHKKRKAEMLMDDGMLGSGPVLGLAGHPHGLVGALAPPPPPPM 371
            :|||:::||         :..:.:.||
Mouse   342 KIILEEMKE---------KFSMRNGKR-------------------------------------- 359

  Fly   372 KQPQMDIPSGKKQLQQLKGATVAASALEYQYQVMYAHCVQKEREREREHLPHSHPLPRQHRAVLV 436
            .|.:.|.|||.:              |...|.|:         ::|.:|:|.:|.        .:
Mouse   360 IQSKTDTPSGME--------------LPSWYPVI---------KQEGDHVPQTHS--------FL 393

  Fly   437 ATTPYPHLPQYPTPPTLNSSSAFRPWGPDTTKAFLHAYGATLSSLP------------------- 482
            ..:.|.::......|.::.:|| .....:.|||......:..|..|
Mouse   394 HPSYYLYMCDKVVAPNVSLTSA-ASQSKEATKAETSKSTSKQSEKPHESSQHQKTVSYPDVSLEE 457

  Fly   483 ------------YACQEPPELQNPE----------RVVRSTDKRYAERTYQPNVALAPRKSILSK 525
                        |:|.:.....|..          .:||.|.||.:|.:          ..:|.:
Mouse   458 QEKMDLKTSRELYSCLDSSISNNSTSRKKSESAVCSLVRGTSKRDSEDS----------SPLLVR 512

  Fly   526 ERDKDRERMEREVMERQRLREKETDHQVVHIKQE 559
            :.:.|:.::..:|| |..:|::|..:.::..||:
Mouse   513 DGEDDKGKIMEDVM-RTYVRQQEKLNSILQRKQQ 545

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Snoo	NP_001097115.1	Ski_Sno	114..207	CDD:280577	57/92 (62%)
		c-SKI_SMAD_bind	226..317	CDD:198114	45/93 (48%)
Skil	NP_035516.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..28		4/9 (44%)
		Ski_Sno	133..232	CDD:367087	58/99 (59%)
		c-SKI_SMAD_bind	258..353	CDD:198114	45/103 (44%)
		EnvC	402..>661	CDD:227278	26/156 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	415..461		6/46 (13%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	475..518		8/52 (15%)
		SMC_prok_B	<537..>663	CDD:274008	2/9 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	120	1.000	Domainoid score	I5736
eggNOG	1	0.900	-	-		E1_28KYF
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002607
OrthoInspector	1	1.000	-	-		otm42567
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR10005
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.910