DRSC/TRiP Functional Genomics Resources

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Protein Alignment Snoo and daf-5

DIOPT Version :10

Sequence 1:NP_609164.3 Gene:Snoo / 5740414 FlyBaseID:FBgn0085450 Length:1223 Species:Drosophila melanogaster
Sequence 2:NP_496941.1 Gene:daf-5 / 175054 WormBaseID:WBGene00000901 Length:627 Species:Caenorhabditis elegans


Alignment Length:595 Identity:113/595 - (18%)
Similarity:194/595 - (32%) Gaps:202/595 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly   121 LEGKTIGCFSVGGEMRLCLPQFLNNVL------NDFSLEQINRIFDELGIYCSQCTHDQL--VEF 177
            |.|..:...|:.||..|.: :.|:::|      :..|.:.:.|.   ..:|....:..|.  |..
 Worm    80 LLGVRVPALSIDGEPHLPI-EILDDMLTKKDKKDQMSFQNLLRY---KNVYIRMASPSQFRAVME 140

  Fly   178 KAAKILPSDVKASGLITRTDAERLCAALLHRSDRNSYVPIESLAKGA------LS--FHVYHKCF 234
            |:.:....::.:..|::|:|.||:...|          .:||:...|      :|  .||.|..|
 Worm   141 KSKECENLNITSLSLMSRSDIERIMGEL----------RLESMLTLAEHDNWDISDRVHVVHVNF 195

  Fly   235 -GKC----------EGICTPDMYSY-----QKPTCIKCLECDGWFSPQKFVGHVHRKFE-NHTCH 282
             ..|          |.:.....:.|     :...||:|..|:|.|:|..|:.|.|...: :...|
 Worm   196 IDYCSEWLESDDLEEDVMQSGTHGYWYKNRRNMRCIECQHCEGKFTPTDFIMHHHYPIKPSGFVH 260

  Fly   283 WGFDSRNWHDYLHVALDVENREKYQIILDQLKEVELKEMHKAQRELEHKKRKAEMLMDDGMLGSG 347
            .|.:|..|...:.| .|..|..     |:...:..|......:||.:.                 
 Worm   261 TGCNSFQWIRLIEV-FDKSNEN-----LEAWNKFVLNSHRAGKREYDE----------------- 302

  Fly   348 PVLGLAGHPHGLVGALAPPPPPPMKQPQMDIP----SGKKQLQQLKGATVAASALEYQYQVMYAH 408
                  ..||     .|||..|.|:.|   :|    :|.:..::.:|..:               
 Worm   303 ------AAPH-----QAPPKRPAMETP---VPVAADNGWEADEEEEGEEI--------------- 338

  Fly   409 CVQKEREREREHLPHSHPLPRQHRAVLVATTPYPHLPQYPTPPTLNSSSAFRPWGPDTTKAFLHA 473
             |.::.:.|:..|.:...:...|.|..:..               :.|...:|     ...|...
 Worm   339 -VDRDADIEKCKLRNKKKMENLHIADFLGP---------------SGSKGLKP-----RNKFEAV 382

  Fly   474 YGATLSSLPYACQEPPELQNPERV---VRSTDKRYAERTYQ------------------------ 511
            ....|:.:..|..|...|::||..   |:.:|..:...|.|                        
 Worm   383 IIEQLNKMDDAALEALFLKSPEEYNLWVKESDFTHKVVTQQQEWKAKMKDPNFKSRASANFDVSK 447

  Fly   512 ---------PNVALAPRKSI--LSKE---RDKDRE---RMEREVMERQRLREKETDHQVVHIKQE 559
                     .|.:.|.|:.|  |:::   .|:|.:   .||..:.|...|:....|    .|:..
 Worm   448 GEFDNMRHFDNASKATRQEIQQLAEQFANLDRDAKLLTPMEFVLREHALLKNVSAD----AIRVL 508

  Fly   560 RSQTPTPPTASPP-----------------------------DGVVLPLDVVEPPHPSSSGS-NS 594
            .::.|.||...||                             .|:.|||.:|.||..|:... .:
 Worm   509 CNRPPLPPLPPPPPPPKPKPAPVQPISLGNINFVALAQQLIASGIKLPLPIVTPPVVSTPAPVIT 573

  Fly   595 PLPAHLPAAP 604
            |:||.||.:|
 Worm   574 PIPAALPISP 583

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SnooNP_609164.3 DHD_Ski_Sno 116..206 CDD:410782 19/92 (21%)
c-SKI_SMAD_bind 226..317 CDD:198114 26/109 (24%)
AF-4 637..>789 CDD:461550
daf-5NP_496941.1 c-SKI_SMAD_bind <229..288 CDD:471667 18/64 (28%)
Blue background indicates that the domain is not in the aligned region.

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