Protein Alignment Snoo and Snoo

DIOPT Version :10

• Sequence 1: NP_609164.3
• Gene: Snoo / 5740414
• FlyBaseID: FBgn0085450
• Length: 1223
• Species: Drosophila melanogaster
• Sequence 2: XP_061512662.1
• Gene: Snoo / 1278189
• VectorBaseID: AGAMI1_005568
• Length: 1291
• Species: Anopheles gambiae
• Alignment Length: 1407
• Identity: 397/1407 - (28%)
• Similarity: 557/1407 - (39%)
• Gaps: 477/1407 - (33%)

  Fly     1 MTEYVTPMISTVLKKYQTSATKSLQGPGHAL-------TTAGVLDIVTNGRSESPGLNGKCQASP 58
            |||||.|.:.:|||.||..|.:||.|||.:|       ...|....:..||:|:|
Mosquito     1 MTEYVPPHVISVLKTYQDKAPRSLHGPGLSLVHPSKAGAATGPGGAIVVGRAETP---------- 55

  Fly    59 PVVALIKKEILSSPEPQDLHHHECSTRGTP---------------PQIYSPATPPRELSQPILSV 108
                    :.|:| :...|.||    .|.|               ||...|..||.. ..||::.
Mosquito    56 --------DHLAS-QHHALSHH----AGEPSGGGGGRAGSDEDELPQPRQPMGPPVP-GVPIMTT 106

  Fly   109 ADAGCGELYETKLEGKTIGCFSVGGEMRLCLPQFLNNVLNDFSLEQINRIFDELGIYCSQCTHDQ 173
            .|..||.|:.|.||||.||||.:|||.||||||..||:|.|||:|||||...||.||...||..|
Mosquito   107 PDPDCGILHMTMLEGKRIGCFLLGGETRLCLPQIFNNILMDFSVEQINRSIQELMIYLYNCTDQQ 171

  Fly   174 LVEFKAAKILPSDVKASGLITRTDAERLCAALLHRSDR-----NSYVPIESLAKGALSFHVYHKC 233
            |.|||.|.|:|...|:.||||||:|||||::|||::..     .|..|..:|..|  ||.|||:|
Mosquito   172 LAEFKRANIIPDTAKSCGLITRTNAERLCSSLLHQAHELRPRLKSGGPGSALLNG--SFRVYHRC 234

  Fly   234 FGKCEGICTPDMYSYQKPTCIKCLECDGWFSPQKFVGHVHRKFENHTCHWGFDSRNWHDYLHVAL 298
            ||:.||:..|::|||.:.:||:|.||.|.|||||||.|.|...|..||||||:|.||..|:|||.
Mosquito   235 FGRGEGLFLPELYSYDEQSCIECAECRGLFSPQKFVCHQHEPQEIRTCHWGFNSSNWRSYIHVAE 299

  Fly   299 DVENREKYQIILDQ--LKEVELKEMHKAQRELEHKKRKAEMLMDDGMLGSGPVLGLAGHPHGLVG 361
            ..:|||::..:||:  |||.|:::..:|:|.....:|||..        .||:
Mosquito   300 SEKNREEHAQVLDKIWLKEREIEQELEAERAFWVARRKAAW--------EGPI------------ 344

  Fly   362 ALAPPPPPPMKQPQMDIPSGKKQLQQLKG----------ATVAASALEY----QYQVMYAHCVQK 412
                    |:|...:|||..|.:|....|          ::|.:|..::    |.|.:..|
Mosquito   345 --------PIKAEPLDIPLKKPKLMNDAGSMYHSSSGSSSSVGSSRTQHYAAQQQQQLLVH---- 397

  Fly   413 EREREREHLPHSHPLPRQHRAVLVATTPYPHLPQYPTPPTLNSSSAFRPWGPDTTKAFLHAYGAT 477
                .:.||.|.|...:|                       .:|:|||||... .||..:|....
Mosquito   398 ----PQSHLLHHHQQSQQ-----------------------QTSAAFRPWTAQ-QKAQKYAQQQQ 434

  Fly   478 LSSL-----PYA------------------------CQEPPELQNPERVVRSTDKRYAERTYQPN 513
            .:.|     |||                        .||||.|||||.||..::....||:||||
Mosquito   435 QALLLQQIAPYANGTGTTIVNGTIRPTSPGGSILALSQEPPLLQNPENVVPMSETDKFERSYQPN 499

  Fly   514 VALAPRKSILS------------KERDKDRERMEREVMERQRLREKETDHQV------------- 553
            |||.|||:||.            :||.:.....:|.|::.:.::.|:.....
Mosquito   500 VALVPRKTILCGKEPPAVSVTAVRERREYDGNKDRSVIKCEMVQIKQESPATPPAIAAGGGAAVD 564

  Fly   554 ----------VHIKQERSQTPTPPTASPPDGVVLPLDVVEPPHPSSSG----SNSPLP---AHLP 601
                      |.||||||.||    ||...|   .||     |....|    |.||.|   ||:|
Mosquito   565 GSMRSVIKCDVQIKQERSGTP----ASAGSG---HLD-----HGGRGGREDNSRSPGPPSSAHIP 617

  Fly   602 AAPATAPPNAGGA---------------------------------PPTPTNLRNMRSPEEFSAG 633
            .:|   ||.||..                                 .|.|..|....|    .:.
Mosquito   618 VSP---PPPAGAIAISTIIAKQQQQQQQHHHQQVSSMATYGNSNSNSPVPIALDAQHS----GSS 675

  Fly   634 GSNEITSSTSPHHQQSSHHQVVQPTAGAPPPSQHIIATVNQHAKLLPSSSSLPNGNGSSSLAA-- 696
            |||||||||||                .|||...|:..:              ||.|.....|
Mosquito   676 GSNEITSSTSP----------------LPPPPSSIVVNM--------------NGGGDGVARARE 710

  Fly   697 -TNNEPSRIRINKNLMS-------------------QQPVVAVSG-----MTP----HHHQHH-P 731
             |.::|..:.|.:.::|                   ||.....||     ::|    ||.:|| |
Mosquito   711 QTGDKPKLVLIKEPIISPPLSTRTPTGRHSPHGHMLQQQQGGGSGHHSQPVSPPPPSHHSEHHQP 775

  Fly   732 THMHHFSHGYYKSQASSPTQSSSAGLNLSTHSSNVVSSPHHATQPKTHHSSVGSGN---HGLQNG 793
            .::||  |...:.|.....|...                |.    ::||....:.:   |  :||
Mosquito   776 MYLHH--HQVLQQQQQQQQQQQQ----------------HF----RSHHPGTTTADTIIH--RNG 816

  Fly   794 KPHLG-SEFELSTDTDDTDSLNGEPDSSAMLPPWEQAVESLRETRPKDRERVLLILQRLLQENDQ 857
            .|.:| ||||||||||| ||..||||||.:....|...|.|:|...:.::::|.|.:.||||: :
Mosquito   817 HPVVGNSEFELSTDTDD-DSQTGEPDSSNVPTTMELIGEVLKEVETETKQQILNIFKVLLQES-R 879

  Fly   858 YRYNNIQLSELLHKQDAHIADLTEQLQRYRRQFEEQVCKVDLRKMPFKHQTRLE-----NVVEAG 917
            ..::.:|: |:..|:|..:     ::||:..:.:.|...:..:    .||.:||     ..:||.
Mosquito   880 VEHHRLQM-EIRAKEDQLM-----EVQRHNMEIQRQTDHLQQQ----NHQLQLELDRALLKIEAL 934

  Fly   918 RGEAEEDEELEEDEMEDRANNNNQQELSPLIKAPANGLRRSVTPPNCCASEGGDCEKPDEPESKR 982
            |....:..:|...:.:    :::||:...:::....|:..|.|           ...|..|.|
Mosquito   935 REHQHQQSQLHHHQQQ----HHHQQQHHIMVRETLGGVGESST-----------SSTPPSPLS-- 982

  Fly   983 IKLQVGEKAEDKQVENEESPSNGTESHDL-EKLEKNDDKTDPTNNP------KSPQPSQISSDDE 1040
                        .|.|   .||...||.| |:.....:|::....|      :||
Mosquito   983 ------------LVSN---GSNSNHSHQLIERRNSFPEKSEIIMKPLKKLLRRSP---------- 1022

  Fly  1041 MEEDDEDEDEEDEDEEVQVEAPHSSALATPPTATTPLSPDSAATAGQLFDSSNSSDESSMKKAQM 1105
                      :|....:.:.:|       ||..|..|.|                        .:
Mosquito  1023 ----------DDATTVLMLASP-------PPQPTGSLPP------------------------AL 1046

  Fly  1106 SACHALEKMSSNVGSDENNQRLAEESQEDEAEEDPEEEDSDDDEMPLQQRQQQQRQRVAPQNVLS 1170
            .||.::...:.:|.           .:....:.|||           ..|:..:||    .:|..
Mosquito  1047 PACLSITATTVSVA-----------PKASSTQSDPE-----------AGREASRRQ----PSVSP 1085

  Fly  1171 GPSVAGHHPAPAHPPMATKASKKQTPPAPPTAAATTTASATT 1212
            .|::.....:|  ||.|.:...:..||.|||:|....||.||
Mosquito  1086 SPTLRAGESSP--PPAALQQPPQPPPPPPPTSATIVPASPTT 1125

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Snoo	NP_609164.3	DHD_Ski_Sno	116..206	CDD:410782	56/89 (63%)
		c-SKI_SMAD_bind	226..317	CDD:198114	51/92 (55%)
		AF-4	637..>789	CDD:461550	38/186 (20%)
Snoo	XP_061512662.1	None