Protein Alignment Snoo and Skil

DIOPT Version :10

• Sequence 1: NP_609164.3
• Gene: Snoo / 5740414
• FlyBaseID: FBgn0085450
• Length: 1223
• Species: Drosophila melanogaster
• Sequence 2: NP_001385519.1
• Gene: Skil / 114208
• RGDID: 621399
• Length: 677
• Species: Rattus norvegicus
• Alignment Length: 627
• Identity: 172/627 - (27%)
• Similarity: 241/627 - (38%)
• Gaps: 230/627 - (36%)

  Fly    57 SPPV-------------VALIKKEIL-----SSPEPQDLH-HHEC-------------------- 82
            ||||             :..:|||.|     :|.||...| ...|
  Rat    26 SPPVKKMMTDIHANGKTLTQVKKEHLDDYGDASVEPDGEHAKRNCPSLPETLNLNPSLKHTLAQF 90

  Fly    83 -----STRGTP-------------PQIYSPATPPRELSQPILSVADAGCGELYETKLEGKTIGCF 129
                 |:.|.|             |.::.|...|:.|..|:|..:|:.. ||.:|.|||::|.||
  Rat    91 HLSSQSSLGGPAAFSARYSQESMSPTVFLPLPSPQVLPGPLLIPSDSST-ELTQTVLEGESISCF 154

  Fly   130 SVGGEMRLCLPQFLNNVLNDFSLEQINRIFDELGIYCSQCTHDQLVEFKAAKILPSDVKASGLIT 194
            .||||.||||||.||:||.:|||:|||.:.|||.||||:||.|||...|...|||.:..:.||||
  Rat   155 QVGGEKRLCLPQVLNSVLREFSLQQINTVCDELYIYCSRCTSDQLHILKVLGILPFNAPSCGLIT 219

  Fly   195 RTDAERLCAALLHR---SDRNSYVPIES----LAKGALSFHVYHKCFGKCEGICTPDMYSYQKPT 252
            .|||:|||.|||..   ....|.:|.:|    |.:...:|.|.|:|.|||:|:..|..|......
  Rat   220 LTDAQRLCNALLRPRTFPQNGSILPAKSSWAQLKETGSAFEVEHECLGKCQGLFAPQFYVQPDAP 284

  Fly   253 CIKCLECDGWFSPQKFVGHVHRKFENHTCHWGFDSRNWHDYLHV---ALDVENREKYQIILDQLK 314
            ||:||||.|.|:||.||.|.||..:..||||||:|..||.||||   .|.....:|.:|||:::|
  Rat   285 CIQCLECCGMFAPQTFVMHSHRSPDKRTCHWGFESAKWHCYLHVNQKYLGTPEEKKLKIILEEMK 349

  Fly   315 EVELKEMHKAQRELEHKKRKAEMLMDDGMLGSGPVLGLAGHPHGLVGALAPPPPPPMKQPQMDIP 379
            |         :..:.:.||                                      .|.:.|.|
  Rat   350 E---------KFSMRNGKR--------------------------------------IQSKTDTP 367

  Fly   380 SGKKQLQQLKGATVAASALEYQYQVMYAHCVQKEREREREHLPHSHPLPRQHRAVLVATTPYPHL 444
            ||.:                                     ||..:|:.:|..         .|.
  Rat   368 SGME-------------------------------------LPPWYPVIKQEG---------DHG 386

  Fly   445 PQYPTPPTLNSSSAFRPWGPDTTKAFLHAYGATLSSLPYACQEPPELQNPERVVRSTDKRYAERT 509
            ||                    |.:|||.     |...|.|                     ::.
  Rat   387 PQ--------------------THSFLHP-----SYYLYMC---------------------DKV 405

  Fly   510 YQPNVALAPRKS------------ILSKERDKDRERMERE--------VMERQRLREKETDHQVV 554
            ..|||:||...|            .:||:.:|..:..:|:        .:|.|...:.:|..: :
  Rat   406 VAPNVSLASAASQSKAVTKAETSKSISKQSEKPHDSSKRQKTVSYPDVSLEEQEKMDLKTSRE-L 469

  Fly   555 HIKQERSQTPTPPTASPPDGVVLPLDVVEPPHPSSSGSNSPL 596
            :...:.|.:....:....:..:  .|:|.......||::|||
  Rat   470 YSCLDSSVSNNSTSKKKCESTI--CDLVRDTDKQGSGASSPL 509

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Snoo	NP_609164.3	DHD_Ski_Sno	116..206	CDD:410782	55/89 (62%)
		c-SKI_SMAD_bind	226..317	CDD:198114	45/93 (48%)
		AF-4	637..>789	CDD:461550
Skil	NP_001385519.1	DHD_Sno	134..233	CDD:410787	59/99 (60%)
		c-SKI_SMAD_bind	258..353	CDD:198114	45/103 (44%)
		SMC_prok_B	<518..668	CDD:274008